The COVID-19 pandemic continues to impact society and our medical specialty in unpredictable and unprecedented ways ( Although infants and children are at highest risk of respiratory morbidity with viral pathogens, initial presentations of pediatric COVID-19 appears to be less prevalent and severe than in the elderly (Pediatrics 2020; JAMA Pediatr 2020).

However, the evolving nature of this pandemic has linked a severe manifestation of this disease that presents with persistent fevers and features of toxic shock syndrome or Kawasaki disease. Pediatric multisystem inflammatory syndrome was initially characterized in a series from London, U.K. (Lancet 2020). Given the evolving challenges of the COVID-19 crisis on pediatric perioperative medicine, the pediatric anesthesia community has responded to this call to duty.

The declaration of the National Emergency on COVID-19 outbreak prompted the American College of Surgeons (ACS) to issue guidance on a “plan...

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