A previously healthy 29-year-old man is involved in a motor vehicle collision. He arrives at your trauma center with a blood pressure of 83/42 mm Hg, a heart rate of 122 beats/min, and obvious lower extremity fractures. In addition to fresh frozen plasma (FFP), you plan on administering 4-factor prothrombin complex concentrate (4-PCC). According to a recent study comparing this combination with administration of FFP alone, which of the following outcomes was MOST likely to occur in the dual therapy group?
Trauma-induced coagulopathy, consisting of the lethal triad of acidosis, hypothermia, and depletion of coagulation factors, leads to increased mortality after trauma. Prevention or reversal of coagulopathy requires a balanced transfusion strategy of PRBCs, FFP, and platelets to mimic whole blood. 4-PCC consists of the coagulation factors II, VII, IX, and X. It was initially developed for the treatment of hemophilia but is now approved by the U.S. Food and...
