A recent systematic review and meta-analysis compared hyperbaric bupivacaine with isobaric bupivacaine for spinal anesthesia in adults undergoing nonobstetric surgery. Based on the results of this study, which of the following statements is most likely true?
Approximately 5 percent of surgical procedures are performed under spinal anesthesia each year, which translates to about 15 million cases worldwide. Bupivacaine is the most commonly used medication for spinal anesthesia, and two forms are commercially available: isobaric bupivacaine and hyperbaric bupivacaine. For more than 30 years, there has been little objective evidence regarding the effectiveness and safety of these two formulations (even though only 0.75 percent hyperbaric bupivacaine is approved by the U.S. Food and Drug Administration for spinal anesthesia and is the most commonly used formulation). Recently, however, two large meta-analyses have provided useful information to better guide clinicians. This is especially relevant given the recent national shortage of 0.75 percent hyperbaric...
