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Articles

Temporal Transitions in Fibrinolysis after Trauma: Adverse Outcome Is Principally Related to Late Hypofibrinolysis

Andrea Rossetto, M.D., Paul Vulliamy, Ph.D., Kim May Lee, Ph.D., Karim Brohi, M.D., Ross Davenport, Ph.D.

Anesthesiology. January 2022: 136(1):148–161

https://doi.org/10.1097/ALN.0000000000004036

Published: January 2022

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Articles

Reversing Rivaroxaban Anticoagulation as Part of a Multimodal Hemostatic Intervention in a Polytrauma Animal Model

Farahnaz Rayatdoost, M.Sc., Till Braunschweig, M.D., Benjamin Maron, M.D., Herbert Schöchl, M.D., Necib Akman, M.D., Rolf Rossaint, M.D., Eva Herzog, Ph.D., Stefan Heitmeier, Ph.D., Oliver Grottke, M.D., Ph.D., M.Sc.

Anesthesiology. October 2021: 135(4):673–685

https://doi.org/10.1097/ALN.0000000000003899

Published: October 2021

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Articles

Safety of Tranexamic Acid in Hip and Knee Arthroplasty in High-risk Patients

Jashvant Poeran, M.D., Ph.D., Jimmy J. Chan, M.D., Nicole Zubizarreta, M.P.H., Madhu Mazumdar, Ph.D., Leesa M. Galatz, M.D., Calin S. Moucha, M.D.

Anesthesiology. July 2021: 135(1):57–68

https://doi.org/10.1097/ALN.0000000000003772

Published: July 2021

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Articles

Tranexamic Acid in High-risk Arthroplasty Patients: How Will We Adapt to Evolving Evidence?

Douglas A. Colquhoun, M.B., Ch.B., M.Sc., M.P.H., Brian R. Hallstrom, M.D., Sachin Kheterpal, M.D., M.B.A.

Anesthesiology. July 2021: 135(1):12–14

https://doi.org/10.1097/ALN.0000000000003842

Published: July 2021

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Articles

Exposure–Response Relationship of Tranexamic Acid in Cardiac Surgery: A Model-based Meta-analysis

Paul Jacques Zufferey, M.D., Ph.D., Julien Lanoiselée, M.D., Billal Graouch, M.B.S.S., Baptiste Vieille, M.B.S.S., Xavier Delavenne, Pharm.D., Ph.D., Edouard Ollier, M.D., Ph.D.

Anesthesiology. February 2021: 134(2):165–178

https://doi.org/10.1097/ALN.0000000000003633

Published: February 2021

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Articles

Optimal Tranexamic Acid Dosing Regimen in Cardiac Surgery: What Are the Missing Pieces?

David Faraoni, M.D., Ph.D., F.A.H.A., Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M.

Anesthesiology. February 2021: 134(2):143–146

https://doi.org/10.1097/ALN.0000000000003637

Published: February 2021

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Articles

Antifibrinolytic Therapy and Perioperative Considerations

Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M., Andreas Koster, M.D., Quintin J. Quinones, M.D., Ph.D., Truman J. Milling, M.D., Nigel S. Key, M.B., Ch.B., F.R.C.P.

Anesthesiology. March 2018: 128(3):657–670

https://doi.org/10.1097/ALN.0000000000001997

Published: March 2018

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Articles

Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma

Markus Honickel, M.D., Till Braunschweig, M.D., Rolf Rossaint, M.D., Christian Stoppe, M.D., Hugo ten Cate, M.D., Ph.D., Oliver Grottke, M.D., Ph.D.

Anesthesiology. November 2017: 127(5):852–861

https://doi.org/10.1097/ALN.0000000000001856

Published: November 2017

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Articles

Intravenous Tranexamic Acid Bolus plus Infusion Is Not More Effective than a Single Bolus in Primary Hip Arthroplasty: A Randomized Controlled Trial

Paul J. Zufferey, M.D., Ph.D., Julien Lanoiselée, M.B.B.S., Céline Chapelle, M.Sc., Dmitry B. Borisov, M.D., Jean-Yves Bien, M.D., Pierre Lambert, M.D., Rémi Philippot, M.D., Ph.D., Serge Molliex, M.D., Ph.D., Xavier Delavenne, Pharm.D., Ph.D., for the investigators of the PeriOpeRative Tranexamic acid in hip arthrOplasty (PORTO) Study

Anesthesiology. September 2017: 127(3):413–422

https://doi.org/10.1097/ALN.0000000000001787

Published: September 2017

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Articles

Tranexamic Acid: What Is Known and Unknown, and Where Do We Go From Here?

Susan M. Goobie, M.D., F.R.C.P.C., Steven M. Frank, M.D.

Anesthesiology. September 2017: 127(3):405–407

https://doi.org/10.1097/ALN.0000000000001788

Published: September 2017

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Articles

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

Irene Lecker, Ph.D., Dian-Shi Wang, M.D., Ph.D., Kirusanthy Kaneshwaran, B.S., C. David Mazer, M.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. July 2017: 127(1):89–97

https://doi.org/10.1097/ALN.0000000000001665

Published: July 2017

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Articles

Pharmacokinetics of Tranexamic Acid in Neonates, Infants, and Children Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Mark C. Wesley, M.D., Luis M. Pereira, Ph.D., Laurie A. Scharp, B.S., Sitaram M. Emani, M.D., Francis X. McGowan, Jr., M.D., James A. DiNardo, M.D.

Anesthesiology. April 2015: 122(4):746–758

https://doi.org/10.1097/ALN.0000000000000570

Published: April 2015

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Articles

Comparison of Two Doses of Tranexamic Acid in Adults Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Stéphanie Sigaut, M.D., Benjamin Tremey, M.D., Alexandre Ouattara, M.D., Ph.D., Roland Couturier, M.D., Christian Taberlet, M.D., Stanislas Grassin-Delyle, Pharm.D., Ph.D., Jean-Francois Dreyfus, M.D., Ph.D., Sylvie Schlumberger, M.D., Marc Fischler, M.D.

Anesthesiology. March 2014: 120(3):590–600

https://doi.org/10.1097/ALN.0b013e3182a443e8

Published: March 2014

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Articles

Tranexamic Acid Impairs γ-Aminobutyric Acid Receptor Type A–mediated Synaptic Transmission in the Murine Amygdala: A Potential Mechanism for Drug-induced Seizures?

Stephan Kratzer, M.D., Hedwig Irl, M.S., Corinna Mattusch, Ph.D., Martina Bürge, M.D., Jörg Kurz, M.D., Eberhard Kochs, M.D., Matthias Eder, Ph.D., Gerhard Rammes, Ph.D., Rainer Haseneder, M.D.

Anesthesiology. March 2014: 120(3):639–649

https://doi.org/10.1097/ALN.0000000000000103

Published: March 2014

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Articles

A Practical Tranexamic Acid Dosing Scheme Based on Population Pharmacokinetics in Children Undergoing Cardiac Surgery

Stanislas Grassin-Delyle, Pharm.D., Ph.D., Roland Couturier, M.D., Emuri Abe, Pharm.D., Jean Claude Alvarez, Pharm.D., Ph.D., Philippe Devillier, M.D., Ph.D., Saïk Urien, M.D., Ph.D.

Anesthesiology. April 2013: 118(4):853–862

https://doi.org/10.1097/ALN.0b013e318283c83a

Published: April 2013

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Articles

Tranexamic Acid in Elective Craniosynostosis Surgery: It Works, but How?

John B. Holcomb, M.D., F.A.C.S.

Anesthesiology. April 2011: 114(4):737–738

https://doi.org/10.1097/ALN.0b013e3182110083

Published: April 2011

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Articles

Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery: A Double-blind, Placebo-controlled Trial

Susan M. Goobie, M.D., F.R.C.P.C., Petra M. Meier, M.D., Luis M. Pereira, Ph.D., Francis X. McGowan, M.D., Randy P. Prescilla, M.D., Laurie A. Scharp, B.Sc., Gary F. Rogers, M.D., Mark R. Proctor, M.D., John G. Meara, M.D., Sulpicio G. Soriano, M.D., David Zurakowski, Ph.D., Navil F. Sethna, M.D.

Anesthesiology. April 2011: 114(4):862–871

https://doi.org/10.1097/ALN.0b013e318210fd8f

Published: April 2011

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Articles

Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery: A Randomized Double-blind Study

Christophe Dadure, M.D., Ph.D., Magali Sauter, M.D., Sophie Bringuier, Pharm.D., Ph.D., Michelle Bigorre, M.D., Olivier Raux, M.D., M.Sc., Alain Rochette, M.D., Nancy Canaud, M.D., Xavier Capdevila, M.D., Ph.D.

Anesthesiology. April 2011: 114(4):856–861

https://doi.org/10.1097/ALN.0b013e318210f9e3

Published: April 2011

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Articles

Anesthesia Literature Review

Timothy J. Brennan, Ph.D., M.D.

Anesthesiology. November 2010: 113(5):1199–1204

https://doi.org/10.1097/ALN.0b013e3181f69252

Published: November 2010

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Articles

CU-2010—A Novel Small Molecule Protease Inhibitor with Antifibrinolytic and Anticoagulant Properties

Wulf Dietrich, M.D., Ph.D., Silke Nicklisch, M.Sc., Andreas Koster, M.D., Ph.D., Michael Spannagl, M.D., Ph.D., Helmut Giersiefen, Ph.D., Andreas van de Locht, Ph.D.

Anesthesiology. January 2009: 110(1):123–130

https://doi.org/10.1097/ALN.0b013e318191408c

Published: January 2009

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NARROW

Temporal Transitions in Fibrinolysis after Trauma: Adverse Outcome Is Principally Related to Late Hypofibrinolysis

Reversing Rivaroxaban Anticoagulation as Part of a Multimodal Hemostatic Intervention in a Polytrauma Animal Model

Safety of Tranexamic Acid in Hip and Knee Arthroplasty in High-risk Patients

Tranexamic Acid in High-risk Arthroplasty Patients: How Will We Adapt to Evolving Evidence?

Exposure–Response Relationship of Tranexamic Acid in Cardiac Surgery: A Model-based Meta-analysis

Optimal Tranexamic Acid Dosing Regimen in Cardiac Surgery: What Are the Missing Pieces?

Antifibrinolytic Therapy and Perioperative Considerations

Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma

Intravenous Tranexamic Acid Bolus plus Infusion Is Not More Effective than a Single Bolus in Primary Hip Arthroplasty: A Randomized Controlled Trial

Tranexamic Acid: What Is Known and Unknown, and Where Do We Go From Here?

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

Pharmacokinetics of Tranexamic Acid in Neonates, Infants, and Children Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Comparison of Two Doses of Tranexamic Acid in Adults Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Tranexamic Acid Impairs γ-Aminobutyric Acid Receptor Type A–mediated Synaptic Transmission in the Murine Amygdala: A Potential Mechanism for Drug-induced Seizures?

A Practical Tranexamic Acid Dosing Scheme Based on Population Pharmacokinetics in Children Undergoing Cardiac Surgery

Tranexamic Acid in Elective Craniosynostosis Surgery: It Works, but How?

Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery: A Double-blind, Placebo-controlled Trial

Intraoperative Tranexamic Acid Reduces Blood Transfusion in Children Undergoing Craniosynostosis Surgery: A Randomized Double-blind Study

Anesthesia Literature Review

CU-2010—A Novel Small Molecule Protease Inhibitor with Antifibrinolytic and Anticoagulant Properties

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