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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Ricardo Alvarez-Jimenez, M.D., Ph.D., Maud A. S. Weerink, M.D., Laura N. Hannivoort, M.D., Ph.D., Hong Su, Pharm.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Stephan A. Loer, M.D., Ph.D., Pieter J. Colin, Pharm.D., Ph.D.

Anesthesiology. February 2022: 136(2):279–292

DOI: https://doi.org/10.1097/ALN.0000000000004049

Published: February 2022

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Articles

Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children

Brian J. Anderson, Ph.D., F.A.N.Z.C.A., F.C.I.C.M., Oliver Bagshaw, M.B.Ch.B., F.R.C.A.

Anesthesiology. July 2019: 131(1):164–185

DOI: https://doi.org/10.1097/ALN.0000000000002657

Published: July 2019

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Prediction of Bispectral Index during Target-controlled Infusion of Propofol and Remifentanil: A Deep Learning Approach

Hyung-Chul Lee, M.D., Ho-Geol Ryu, M.D., Ph.D., Eun-Jin Chung, M.D., Chul-Woo Jung, M.D., Ph.D.

Anesthesiology. March 2018: 128(3):492–501

DOI: https://doi.org/10.1097/ALN.0000000000001892

Published: March 2018

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Articles

Oxford Handbook of Anaesthesia, 4th Edition.

Philip Lebowitz, M.D., M.B.A.

Anesthesiology. July 2016: 125(1):258

DOI: https://doi.org/10.1097/ALN.0000000000001141

Published: July 2016

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Articles

Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy

Christian Jeleazcov, M.D., M.Sc., Harald Ihmsen, Ph.D., Teijo I. Saari, M.D., Ph.D., Doris Rohde, M.D., Jan Mell, M.D., Katharina Fröhlich, M.D., Ljubica Krajinovic, M.D., Jörg Fechner, M.D., Helmut Schwilden, M.D., Ph.D., Jürgen Schüttler, M.D.

Anesthesiology. January 2016: 124(1):56–68

DOI: https://doi.org/10.1097/ALN.0000000000000937

Published: January 2016

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Articles

Development of an Optimized Pharmacokinetic Model of Dexmedetomidine Using Target-controlled Infusion in Healthy Volunteers

Laura N. Hannivoort, M.D., Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Ph.D., Koen M. E. M. Reyntjens, M.D., Anthony R. Absalom, M.B.Ch.B., M.D., Hugo E. M. Vereecke, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.

Anesthesiology. August 2015: 123(2):357–367

DOI: https://doi.org/10.1097/ALN.0000000000000740

Published: August 2015

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Articles

Anesthesiology.

Warner Smith, M.D.

Anesthesiology. December 2008: 109(6):1147

DOI: https://doi.org/10.1097/ALN.0b013e31818dd90e

Published: December 2008

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Articles

Target-controlled Infusions for Intravenous Anesthetics: Surfing USA Not!

Talmage D. Egan, M.D., Steven L. Shafer, M.D.

Anesthesiology. November 2003: 99(5):1039–1041

DOI: https://doi.org/10.1097/00000542-200311000-00003

Published: November 2003

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Articles

Pharmacokinetics of Propofol Administered by Target-controlled Infusion to Alcoholic Patients

Frédérique S. Servin, M.D., Bernard Bougeois, M.D., Roberto Gomeni, Ph.D., France Mentré, M.D., Ph.D., Robert Farinotti, Ph.D., Jean-Marie Desmonts, M.D.

Anesthesiology. September 2003: 99(3):576–585

DOI: https://doi.org/10.1097/00000542-200309000-00012

Published: September 2003

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Articles

Comparison of Plasma Compartment versus Two Methods for Effect Compartment–controlled Target-controlled Infusion for Propofol

Michel M. R. F. Struys, M.D., Ph.D., Tom De Smet, M.Sc., Birgit Depoorter, M.D., Linda F. M. Versichelen, M.D., Eric P. Mortier, M.D., D.Sc., Frank J. E. Dumortier, M.D., Steven L. Shafer, M.D., Georges Rolly, M.D., Ph.D.

Anesthesiology. February 2000: 92(2):399

DOI: https://doi.org/10.1097/00000542-200002000-00021

Published: February 2000

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Articles

Population Pharmacokinetics of Midazolam Administered by Target Controlled Infusion for Sedation following Coronary Artery Bypass Grafting

Katayoun Zomorodi, PhD, Andrew Donner, MD, Jacques Somma, MD, Juliana Barr, MD, Robert Sladen, MB, ChB, MRCP(UK), FRCP(C), James Ramsay, MD, Eran Geller, MD, Steven L. Shafer, MD

Anesthesiology. December 1998: 89(6):1418–1429

DOI: https://doi.org/10.1097/00000542-199812000-00020

Published: December 1998

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Articles

Population Pharmacodynamics of Midazolam Administered by Target Controlled Infusion in SICU Patients after CABG Surgery

Jacques Somma, MD, Andrew Donner, MD, Katayoun Zomorodi, PhD, Robert Sladen, MBChB, MRCP(UK), FRCP(C), James Ramsay, MD, Eran Geller, MD, Steven L. Shafer, MD

Anesthesiology. December 1998: 89(6):1430–1443

DOI: https://doi.org/10.1097/00000542-199812000-00021

Published: December 1998

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Articles

Multicenter Study of Target-Controlled Infusion of Propofol-Sufentanil or Sufentanil-Midazolam for Coronary Artery Bypass Graft Surgery

Uday Jain, PhD, MD, Simon C. Body, MB, ChB, FANZCA, Wayne Bellows, MD, Richard Wolman, MD, Christina Mora Mangano, MD, Joseph Mathew, MD, Elizabeth Youngs, MD, Robert Wilson, PhD, Adam Zhang, MD, Dennis T. Mangano, PhD, MD

Anesthesiology. September 1996: 85(3):522–535.

DOI: https://doi.org/10.1097/00000542-199609000-00011

Published: September 1996

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Articles

Pharmacokinetic Model Selection for Target Controlled Infusions of Propofol: Assessment of Three Parameter Sets

J. F Coetzee, BSc, MMed (Anes.) MBChB, DipDat, PhD, J. B. Glen, BVMS, PhD, DVA, Wium, C. A., MSc.(Pharm.), L. Boshoff, MBChB, MMed (Anes.), FFA (SA)

Anesthesiology. June 1995: 82(6):1328–1345.

DOI: https://doi.org/10.1097/00000542-199506000-00003

Published: June 1995

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NARROW

Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children

Prediction of Bispectral Index during Target-controlled Infusion of Propofol and Remifentanil: A Deep Learning Approach

Oxford Handbook of Anaesthesia, 4th Edition.

Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy

Development of an Optimized Pharmacokinetic Model of Dexmedetomidine Using Target-controlled Infusion in Healthy Volunteers

Anesthesiology.

Target-controlled Infusions for Intravenous Anesthetics: Surfing USA Not!

Pharmacokinetics of Propofol Administered by Target-controlled Infusion to Alcoholic Patients

Comparison of Plasma Compartment versus Two Methods for Effect Compartment–controlled Target-controlled Infusion for Propofol

Population Pharmacokinetics of Midazolam Administered by Target Controlled Infusion for Sedation following Coronary Artery Bypass Grafting

Population Pharmacodynamics of Midazolam Administered by Target Controlled Infusion in SICU Patients after CABG Surgery

Multicenter Study of Target-Controlled Infusion of Propofol-Sufentanil or Sufentanil-Midazolam for Coronary Artery Bypass Graft Surgery

Pharmacokinetic Model Selection for Target Controlled Infusions of Propofol: Assessment of Three Parameter Sets

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