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Early Restrictive Fluid Strategy Impairs the Diaphragm Force in Lambs with Acute Respiratory Distress Syndrome

Marloes M. Ijland, M.D., Saranke A. Ingelse, M.D., Ph.D., Lex M. van Loon, M.Sc., Ph.D., Merijn van Erp, M.Sc., Benno Kusters, M.D., Ph.D., Coen A. C. Ottenheijm, Ph.D., Matthijs Kox, Ph.D., Johannes G. van der Hoeven, M.D., Ph.D., Leo M. A. Heunks, M.D., Ph.D., Joris Lemson, M.D., Ph.D.

Anesthesiology. May 2022: 136(5):749–762

DOI: https://doi.org/10.1097/ALN.0000000000004162

Published: May 2022

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Articles

Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep

Congli Zeng, M.D., Ph.D., Gabriel C. Motta-Ribeiro, Ph.D., Takuga Hinoshita, M.D., Ph.D., Marcos Adriano Lessa, M.D., Ph.D., Tilo Winkler, Ph.D., Kira Grogg, Ph.D., Nathan M. Kingston, B.S., John N. Hutchinson, Ph.D., Lynette Marie Sholl, M.D., Xiangming Fang, M.D., Ph.D., Xaralabos Varelas, Ph.D., Matthew D. Layne, Ph.D., Rebecca M. Baron, M.D., Marcos F. Vidal Melo, M.D., Ph.D.

Anesthesiology. November 2020: 133(5):1060–1076

DOI: https://doi.org/10.1097/ALN.0000000000003491

Published: November 2020

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Articles

Resuscitation with Hydroxyethyl Starch Maintains Hemodynamic Coherence in Ovine Hemorrhagic Shock

Philip-Helge Arnemann, M.D., Michael Hessler, M.D., Tim Kampmeier, M.D., Laura Seidel, M.D., Youssef Malek, M.D., Hugo Van Aken, M.D., Ph.D., Andrea Morelli, M.D., Ph.D., Sebastian Rehberg, M.D., Ph.D., Can Ince, Ph.D., Christian Ertmer, M.D., Ph.D.

Anesthesiology. January 2020: 132(1):131–139

DOI: https://doi.org/10.1097/ALN.0000000000002998

Published: January 2020

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Articles

Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model

Jayesh A. Dhanani, Ph.D., Sara Diab, B.N., R.N., Jivesh Chaudhary, F.R.A.C.S., Jeremy Cohen, Ph.D., Suzanne L. Parker, Ph.D., Steven C. Wallis, Ph.D., Clément Boidin, M.Sc., Adrian Barnett, Ph.D., Michelle Chew, Ph.D., Jason A. Roberts, Ph.D., John F. Fraser, Ph.D.

Anesthesiology. August 2019: 131(2):344–355

DOI: https://doi.org/10.1097/ALN.0000000000002752

Published: August 2019

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Articles

Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity

Tyler J. Wellman, Ph.D., Nicolas de Prost, M.D., Ph.D., Mauro Tucci, M.D., Ph.D., Tilo Winkler, Ph.D., Rebecca M. Baron, M.D., Piotr Filipczak, Ph.D., Benjamin Raby, M.D., M.P.H., Jen-hwa Chu, Ph.D., R. Scott Harris, M.D., Guido Musch, M.D., Luiz F. dos Reis Falcao, M.D., Ph.D., Vera Capelozzi, M.D., Ph.D., Jose G. Venegas, Ph.D., Marcos F. Vidal Melo, M.D., Ph.D.

Anesthesiology. November 2016: 125(5):992–1004

DOI: https://doi.org/10.1097/ALN.0000000000001334

Published: November 2016

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Articles

Extracorporeal Carbon Dioxide Removal Enhanced by Lactic Acid Infusion in Spontaneously Breathing Conscious Sheep

Vittorio Scaravilli, M.D., Stefan Kreyer, M.D., Slava Belenkiy, M.D., Katharina Linden, M.D., Alberto Zanella, M.D., Yansong Li, M.D., Michael A. Dubick, Ph.D., Leopoldo C. Cancio, M.D., Antonio Pesenti, M.D., Andriy I. Batchinsky, M.D.

Anesthesiology. March 2016: 124(3):674–682

DOI: https://doi.org/10.1097/ALN.0000000000000995

Published: March 2016

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Articles

Fiber-optic Monitoring of Spinal Cord Hemodynamics in Experimental Aortic Occlusion

Angela S. Kogler, M.S., Thomas V. Bilfinger, M.D., Robert M. Galler, M.D., Rickson C. Mesquita, Ph.D., Michael Cutrone, B.S., Steven S. Schenkel, B.E., Arjun G. Yodh, Ph.D., Thomas F. Floyd, M.D.

Anesthesiology. December 2015: 123(6):1362–1373

DOI: https://doi.org/10.1097/ALN.0000000000000883

Published: December 2015

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Articles

Renal Effects of Saline-based 10% Pentastarch versus 6% Tetrastarch Infusion in Ovine Endotoxemic Shock: Erratum

Anesthesiology. April 2015: 122(4):958

DOI: https://doi.org/10.1097/01.anes.0000462510.56494.41

Published: April 2015

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Articles

Higher Frequency Ventilation Attenuates Lung Injury during High-frequency Oscillatory Ventilation in Sheep Models of Acute Respiratory Distress Syndrome

Songqiao Liu, M.D., Yang Yi, M.D., Ph.D., Maohua Wang, M.D., Qiuhua Chen, M.D., Yingzi Huang, M.D., Ling Liu, M.D., Jianfeng Xie, M.D., Dunyuan Zhou, B.Sc., Haibo Qiu, M.D., Ph.D.

Anesthesiology. August 2013: 119(2):398–411

DOI: https://doi.org/10.1097/ALN.0b013e31829419a6

Published: August 2013

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Articles

Effects of Volatile Anesthetic Agents on Cerebral Cortical Synchronization in Sheep

Duan Li, Ph.D., Logan J. Voss, Ph.D., Jamie W. Sleigh, M.D., Xiaoli Li, Ph.D.

Anesthesiology. July 2013: 119(1):81–88

DOI: https://doi.org/10.1097/ALN.0b013e31828e894f

Published: July 2013

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Articles

Regional Lung Derecruitment and Inflammation during 16 Hours of Mechanical Ventilation in Supine Healthy Sheep

Mauro R. Tucci, M.D., Ph.D., Eduardo L. V. Costa, M.D., Ph.D., Tyler J. Wellman, M.S., Guido Musch, M.D., Tilo Winkler, Ph.D., R. Scott Harris, M.D., Jose G. Venegas, Ph.D., Marcelo B. P. Amato, M.D., Ph.D., Marcos F. Vidal Melo, M.D., Ph.D.

Anesthesiology. July 2013: 119(1):156–165

DOI: https://doi.org/10.1097/ALN.0b013e31829083b8

Published: July 2013

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Articles

Anesthetic Techniques for Fetal Surgery: Effects of Maternal Anesthesia on Intraoperative Fetal Outcomes in a Sheep Model

Pornswan Ngamprasertwong, M.D., M.S., Erik C. Michelfelder, M.D., Shahriar Arbabi, M.D., Yun Suk Choi, M.D., Christopher Statile, M.D., Lili Ding, Ph.D., Anne Boat, M.D., Pirooz Eghtesady, M.D., Ph.D., Katherine Holland, M.D., Ph.D., Senthilkumar Sadhasivam, M.D., M.P.H.

Anesthesiology. April 2013: 118(4):796–808

DOI: https://doi.org/10.1097/ALN.0b013e318283c954

Published: April 2013

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Articles

Pulmonary Hypertension in Lambs Transfused with Stored Blood Is Prevented by Breathing Nitric Oxide

David M. Baron, M.D., Binglan Yu, Ph.D., Chong Lei, M.D., Ph.D., Aranya Bagchi, M.D., Arkadi Beloiartsev, M.D., Christopher P. Stowell, M.D., Ph.D., Andrea U. Steinbicker, M.D., Rajeev Malhotra, M.D., Kenneth D. Bloch, M.D., Warren M. Zapol, M.D.

Anesthesiology. March 2012: 116(3):637–647

DOI: https://doi.org/10.1097/ALN.0b013e318246ef77

Published: March 2012

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Articles

Toll-Like Receptor 4 Inhibitor TAK-242 Attenuates Acute Kidney Injury in Endotoxemic Sheep

Johan Fenhammar, M.D., Mats Rundgren, M.D., Ph.D., Jakob Forestier, M.D., Sigridur Kalman, M.D., Ph.D., Stefan Eriksson, O.D., Ph.D., Robert Frithiof, M.D., Ph.D.

Anesthesiology. May 2011: 114(5):1130–1137

DOI: https://doi.org/10.1097/ALN.0b013e31820b8b44

Published: May 2011

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Articles

Effects of Early Neuronal and Delayed Inducible Nitric Oxide Synthase Blockade on Cardiovascular, Renal, and Hepatic Function in Ovine Sepsis

Matthias Lange, M.D., Atsumori Hamahata, M.D., Daniel L. Traber, Ph.D., Yoshimitsu Nakano, M.D., Aimalohi Esechie, Ph.D., Collette Jonkam, M.D., Elbert B. Whorton, M.S., Ph.D., Sanna von Borzyskowski, Lillian D. Traber, R.N., Perenlei Enkhbaatar, M.D., Ph.D.

Anesthesiology. December 2010: 113(6):1376–1384

DOI: https://doi.org/10.1097/ALN.0b013e3181fc5588

Published: December 2010

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Articles

Implicit Memory Formation during Routine Anesthesia in Children: A Double-masked Randomized Controlled Trial

Xiuzhi Pham, B.Med.Sc., Katherine R. Smith, B.Sc.(Hons), M.Biostat., Suzette J. Sheppard, B.Sc.(Hons), Carolyn Bradshaw, B.Bus.Comp., G.Dip.Psych., Eric Lo, B.Med.Sc., Andrew J. Davidson, M.B.B.S., M.D., F.A.N.Z.C.A.

Anesthesiology. May 2010: 112(5):1097–1104

DOI: https://doi.org/10.1097/ALN.0b013e3181d692c2

Published: May 2010

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Articles

Renal Effects of Saline-based 10% Pentastarch versus 6% Tetrastarch Infusion in Ovine Endotoxemic Shock

Christian Ertmer, M.D., Gabriele Köhler, M.D., Ph.D., Sebastian Rehberg, M.D., Andrea Morelli, M.D., Matthias Lange, M.D., Ph.D., Björn Ellger, M.D., Ph.D., Bernardo Bollen Pinto, M.D., Eva Rübig, Michael Erren, M.D., Lars G. Fischer, M.D., Ph.D., Hugo Van Aken, M.D., Ph.D., F.R.C.A., F.A.N.Z.C.A., Martin Westphal, M.D., Ph.D.

Anesthesiology. April 2010: 112(4):936–947

DOI: https://doi.org/10.1097/ALN.0b013e3181d3d493

Published: April 2010

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Articles

Mild Endotoxemia during Mechanical Ventilation Produces Spatially Heterogeneous Pulmonary Neutrophilic Inflammation in Sheep

Eduardo L. V. Costa, M.D., Ph.D., Guido Musch, M.D., Tilo Winkler, Ph.D., Tobias Schroeder, Ph.D., R. Scott Harris, M.D., Hazel A. Jones, Ph.D., Jose G. Venegas, Ph.D., Marcos F. Vidal Melo, M.D., Ph.D.

Anesthesiology. March 2010: 112(3):658–669

DOI: https://doi.org/10.1097/ALN.0b013e3181cbd1d4

Published: March 2010

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Articles

Sildenafil Prevents Cardiovascular Changes after Bone Marrow Fat Embolization in Sheep

Jörg Krebs, D.V.M., Ph.D., Stephen J. Ferguson, Ph.D., Katja Nuss, D.V.M., Boris Leskosek, Simon P. Hoerstrup, M.D., Ph.D., Ben G. Goss, Ph.D., Nikolaus Aebli, M.D., Ph.D.

Anesthesiology. July 2007: 107(1):75–81

DOI: https://doi.org/10.1097/01.anes.0000267510.81759.aa

Published: July 2007

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Articles

Selective Thromboxane A 2 Synthase Inhibition by OKY-046 Prevents Cardiopulmonary Dysfunction after Ovine Smoke Inhalation Injury

Martin Westphal, M.D., Shinji Noshima, M.D., Tsukasa Isago, M.D., Kentarou Fujioka, M.D., Marc O. Maybauer, M.D., Dirk M. Maybauer, M.D., Lillian D. Traber, John T. Flynn, Ph.D., Beena B. Westphal-Varghese, M.D., Daniel L. Traber, Ph.D.

Anesthesiology. May 2005: 102(5):954–961

DOI: https://doi.org/10.1097/00000542-200505000-00014

Published: May 2005

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NARROW

Early Restrictive Fluid Strategy Impairs the Diaphragm Force in Lambs with Acute Respiratory Distress Syndrome

Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep

Resuscitation with Hydroxyethyl Starch Maintains Hemodynamic Coherence in Ovine Hemorrhagic Shock

Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model

Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity

Extracorporeal Carbon Dioxide Removal Enhanced by Lactic Acid Infusion in Spontaneously Breathing Conscious Sheep

Fiber-optic Monitoring of Spinal Cord Hemodynamics in Experimental Aortic Occlusion

Renal Effects of Saline-based 10% Pentastarch versus 6% Tetrastarch Infusion in Ovine Endotoxemic Shock: Erratum

Higher Frequency Ventilation Attenuates Lung Injury during High-frequency Oscillatory Ventilation in Sheep Models of Acute Respiratory Distress Syndrome

Effects of Volatile Anesthetic Agents on Cerebral Cortical Synchronization in Sheep

Regional Lung Derecruitment and Inflammation during 16 Hours of Mechanical Ventilation in Supine Healthy Sheep

Anesthetic Techniques for Fetal Surgery: Effects of Maternal Anesthesia on Intraoperative Fetal Outcomes in a Sheep Model

Pulmonary Hypertension in Lambs Transfused with Stored Blood Is Prevented by Breathing Nitric Oxide

Toll-Like Receptor 4 Inhibitor TAK-242 Attenuates Acute Kidney Injury in Endotoxemic Sheep

Effects of Early Neuronal and Delayed Inducible Nitric Oxide Synthase Blockade on Cardiovascular, Renal, and Hepatic Function in Ovine Sepsis

Implicit Memory Formation during Routine Anesthesia in Children: A Double-masked Randomized Controlled Trial

Renal Effects of Saline-based 10% Pentastarch versus 6% Tetrastarch Infusion in Ovine Endotoxemic Shock

Mild Endotoxemia during Mechanical Ventilation Produces Spatially Heterogeneous Pulmonary Neutrophilic Inflammation in Sheep

Sildenafil Prevents Cardiovascular Changes after Bone Marrow Fat Embolization in Sheep

Selective Thromboxane A 2 Synthase Inhibition by OKY-046 Prevents Cardiopulmonary Dysfunction after Ovine Smoke Inhalation Injury

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