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Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1–expressing Primary Afferents in Mice

Satoshi Fuseya, M.D., Katsumi Yamamoto, M.D., Hitoshi Minemura, M.D., Satoshi Yamaori, Ph.D., Tomoyuki Kawamata, M.D., Mikito Kawamata, M.D.

Anesthesiology. July 2016: 125(1):204–218

DOI: https://doi.org/10.1097/ALN.0000000000001152

Published: July 2016

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Articles

The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro : Erratum

Anesthesiology. August 2015: 123(2):492

DOI: https://doi.org/10.1097/01.anes.0000466954.80399.b8

Published: August 2015

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Articles

Emulsified Isoflurane Enhances Thermal Transient Receptor Potential Vanilloid-1 Channel Activation–mediated Sensory/Nociceptive Blockade by QX-314

Cheng Zhou, Ph.D., Peng Liang, M.D., Jin Liu, M.D., Wensheng Zhang, M.D., Daqing Liao, M.B., Yanfang Chen, M.B., Xiangdong Chen, M.D., Ph.D., Tao Li, Ph.D.

Anesthesiology. August 2014: 121(2):280–289

DOI: https://doi.org/10.1097/ALN.0000000000000236

Published: August 2014

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Articles

Nociceptor-selective Peripheral Nerve Block Induces Delayed Mechanical Hypersensitivity and Neurotoxicity in Rats

Christopher M. Peters, Ph.D., Douglas Ririe, M.D., Ph.D., Timothy T. Houle, Ph.D., Carol A. Aschenbrenner, M.A., James C. Eisenach, M.D.

Anesthesiology. April 2014: 120(4):976–986

DOI: https://doi.org/10.1097/ALN.0000000000000088

Published: April 2014

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Articles

Differential Effects of Peripheral versus Central Coadministration of QX-314 and Capsaicin on Neuropathic Pain in Rats

Jun Shen, M.D., Lyle E. Fox, Ph.D., Jianguo Cheng, M.D., Ph.D.

Anesthesiology. August 2012: 117(2):365–380

DOI: https://doi.org/10.1097/ALN.0b013e318260de41

Published: August 2012

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Articles

The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro

Ricardo E. Rivera-Acevedo, B.Sc., Stephan A. Pless, Ph.D., Christopher A. Ahern, Ph.D., Stephan K. W. Schwarz, M.D., Ph.D., F.R.C.P.C.

Anesthesiology. June 2011: 114(6):1425–1434

DOI: https://doi.org/10.1097/ALN.0b013e318216ea0c

Published: June 2011

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Articles

Lumbar Intrathecal Administration of the Quaternary Lidocaine Derivative, QX-314, Produces Irritation and Death in Mice

Stephan K. W. Schwarz, M.D., Ph.D., F.R.C.P.C., Helen M.-C. Cheung, B.Sc., Craig R. Ries, M.D., Ph.D., F.R.C.P.C., Sang Mook Lee, M.D., Jimmy T. C. Wang, M.Sc., Bernard A. MacLeod, M.D., F.R.C.P.C.

Anesthesiology. August 2010: 113(2):438–444

DOI: https://doi.org/10.1097/ALN.0b013e3181dfd31b

Published: August 2010

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Articles

2009 in Review: Advancing Medicine in Anesthesiology

Alain Borgeat, M.D., Timothy J. Brennan, Ph.D., M.D., James C. Eisenach, M.D., Hugh C. Hemmings, M.D., Ph.D., Shiroh Isono, M.D., Judy R. Kersten, M.D., Eberhard Kochs, M.D., Ph.D., Bruno Riou, M.D., Ph.D., David S. Warner, M.D., Ph.D.

Anesthesiology. December 2009: 111(6):1192–1196

DOI: https://doi.org/10.1097/ALN.0b013e3181c1879b

Published: December 2009

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Articles

QX-314 Produces Long-lasting Local Anesthesia Modulated by Transient Receptor Potential Vanilloid Receptors in Mice

Craig R. Ries, M.D., Ph.D., F.R.C.P.C., Ray Pillai, B.Sc., Cheryl C. W. Chung, B.Sc., Jimmy T. C. Wang, M.Sc., Bernard A. MacLeod, M.D., F.R.C.P.C., Stephan K. W. Schwarz, M.D., Ph.D., F.R.C.P.C.

Anesthesiology. July 2009: 111(1):122–126

DOI: https://doi.org/10.1097/ALN.0b013e3181a9160e

Published: July 2009

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Articles

Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents

Alexander M. Binshtok, Ph.D., Peter Gerner, M.D., Seog Bae Oh, D.D.S., Ph.D., Michelino Puopolo, Ph.D., Suzuko Suzuki, M.D., David P. Roberson, M.B.A., Teri Herbert, B.Sc., Chi-Fei Wang, M.D., Donghoon Kim, B.S., Gehoon Chung, D.D.S., Aya A. Mitani, M.P.H., Ging Kuo Wang, Ph.D., Bruce P. Bean, Ph.D., Clifford J. Woolf, M.D., Ph.D.

Anesthesiology. July 2009: 111(1):127–137

DOI: https://doi.org/10.1097/ALN.0b013e3181a915e7

Published: July 2009

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Articles

Inhibition of Mammalian Gq Protein Function by Local Anesthetics

Markus W. Hollmann, M.D., Ph.D., William E. McIntire, M.D., Ph.D., James C. Garrison, M.D., Ph.D., Marcel E. Durieux, M.D., Ph.D.

Anesthesiology. December 2002: 97(6):1451–1457

DOI: https://doi.org/10.1097/00000542-200212000-00017

Published: December 2002

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Articles

Local Anesthetic Inhibition of m1 Muscarinic Acetylcholine Signaling

Markus W. Hollmann, M.D., Lars G. Fischer, M.D., Anne M. Byford, M.S., Marcel E. Durieux, M.D., Ph.D.

Anesthesiology. August 2000: 93(2):497–509

DOI: https://doi.org/10.1097/00000542-200008000-00030

Published: August 2000

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Articles

Spinal Tonicaine: Potency and Differential Blockade of Sensory and Motor Functions

Peter Gerner, M.D., Tadashi Nakamura, M.D., Catherine F. Quan, B.A., Douglas C. Anthony, M.D., Ph.D., Ging Kuo Wang, Ph.D.

Anesthesiology. May 2000: 92(5):1350–1360

DOI: https://doi.org/10.1097/00000542-200005000-00025

Published: May 2000

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Articles

A372 EFFECTS OF LIDOCAINE ANALOG QX-314 ON SINGLE CARDIAC SODIUM CHANNELS

Kevin Gingrich, MD, David Yue, MD PhD

Anesthesiology. September 1990: 73(3A):NA

DOI: https://doi.org/10.1097/00000542-199009001-00369

Published: September 1990

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NARROW

Systemic QX-314 Reduces Bone Cancer Pain through Selective Inhibition of Transient Receptor Potential Vanilloid Subfamily 1–expressing Primary Afferents in Mice

The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro : Erratum

Emulsified Isoflurane Enhances Thermal Transient Receptor Potential Vanilloid-1 Channel Activation–mediated Sensory/Nociceptive Blockade by QX-314

Nociceptor-selective Peripheral Nerve Block Induces Delayed Mechanical Hypersensitivity and Neurotoxicity in Rats

Differential Effects of Peripheral versus Central Coadministration of QX-314 and Capsaicin on Neuropathic Pain in Rats

The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro

Lumbar Intrathecal Administration of the Quaternary Lidocaine Derivative, QX-314, Produces Irritation and Death in Mice

2009 in Review: Advancing Medicine in Anesthesiology

QX-314 Produces Long-lasting Local Anesthesia Modulated by Transient Receptor Potential Vanilloid Receptors in Mice

Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents

Inhibition of Mammalian Gq Protein Function by Local Anesthetics

Local Anesthetic Inhibition of m1 Muscarinic Acetylcholine Signaling

Spinal Tonicaine: Potency and Differential Blockade of Sensory and Motor Functions

A372 EFFECTS OF LIDOCAINE ANALOG QX-314 ON SINGLE CARDIAC SODIUM CHANNELS

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