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Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

Pieter Simons, M.D., Rutger van der Schrier, M.D., Maarten van Lemmen, B.Sc., Simone Jansen, M.D., Kiki W.K. Kuijpers, B.Sc., Monique van Velzen, Ph.D., Elise Sarton, M.D., Ph.D., Todd Nicklas, M.S.N., Cathy Michalsky, M.Sc., Mark A. Demitrack, M.D., Michael Fossler, Pharm.D., Ph.D., F.C.P., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D. Ph.D.

Anesthesiology. March 2023: 138(3):249–263

DOI: https://doi.org/10.1097/ALN.0000000000004473

Published: March 2023

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Articles

Ketamine Psychedelic and Antinociceptive Effects Are Connected

Erik Olofsen, Ph.D., Jasper Kamp, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. May 2022: 136(5):792–801

DOI: https://doi.org/10.1097/ALN.0000000000004176

Published: May 2022

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Articles

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Beatrijs I. Valk, M.D., Douglas J. Eleveld, Ph.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.

Anesthesiology. January 2021: 134(1):35–51

DOI: https://doi.org/10.1097/ALN.0000000000003590

Published: January 2021

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Articles

A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine

Shubham Chamadia, Ph.D., Juan C. Pedemonte, M.D., Lauren E. Hobbs, M.A., Hao Deng, M.D., M.P.H., Sarah Nguyen, B.S., Luis I. Cortinez, M.D., Oluwaseun Akeju, M.D., M.M.Sc

Anesthesiology. December 2020: 133(6):1223–1233

DOI: https://doi.org/10.1097/ALN.0000000000003568

Published: December 2020

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Articles

Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine

Albert Dahan, M.D., Ph.D., C. Jan van Dam, M.D., Marieke Niesters, M.D., Ph.D., Monique van Velzen, Ph.D., Michael J. Fossler, Pharm.D., Ph.D., Mark A. Demitrack, M.D., Erik Olofsen, Ph.D.

Anesthesiology. September 2020: 133(3):559–568

DOI: https://doi.org/10.1097/ALN.0000000000003441

Published: September 2020

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Articles

Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part I. Pharmacokinetics and Clinical Pharmacodynamics

Jürgen Schüttler, M.D., Andreas Eisenried, M.D., M.Sc., Marco Lerch, M.D., Jörg Fechner, M.D., Christian Jeleazcov, M.D., M.Sc., Harald Ihmsen, Ph.D.

Anesthesiology. April 2020: 132(4):636–651

DOI: https://doi.org/10.1097/ALN.0000000000003103

Published: April 2020

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Articles

Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part II. Pharmacodynamics of Electroencephalogram Effects

Andreas Eisenried, M.D., M.Sc., Jürgen Schüttler, M.D., Marco Lerch, M.D., Harald Ihmsen, Ph.D., Christian Jeleazcov, M.D., M.Sc.

Anesthesiology. April 2020: 132(4):652–666

DOI: https://doi.org/10.1097/ALN.0000000000003102

Published: April 2020

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Articles

Influence of St. John’s Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial

Michael J. Loughren, Ph.D., C.R.N.A., Evan D. Kharasch, M.D., Ph.D., Megan C. Kelton-Rehkopf, M.A., Karen L. Syrjala, Ph.D., Danny D. Shen, Ph.D.

Anesthesiology. March 2020: 132(3):491–503

DOI: https://doi.org/10.1097/ALN.0000000000003065

Published: March 2020

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Articles

Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy

Maud A. S. Weerink, M.D., Clemens R. M. Barends, M.D., Ernesto R. R. Muskiet, M.D., Koen M. E. M. Reyntjens, M.D., Froukje H. Knotnerus, R.N., Martine Oostra, R.N., Jan F. P. van Bocxlaer, Pharm.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Pieter J. Colin, Pharm.D., Ph.D.

Anesthesiology. November 2019: 131(5):1004–1017

DOI: https://doi.org/10.1097/ALN.0000000000002882

Published: November 2019

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Articles

Where’s the Beef?: How Much Can We Skimp on Pharmacokinetic–Pharmacodynamic Data?

Thomas K. Henthorn, M.D., Erik Olofsen, Ph.D.

Anesthesiology. February 2019: 130(2):186–188

DOI: https://doi.org/10.1097/ALN.0000000000002552

Published: February 2019

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Articles

Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Josh D. Kaullen, Pharm.D., Joel S. Owen, Ph.D., Kim L. R. Brouwer, Pharm.D., Ph.D., Paul M. Heerdt, M.D., Ph.D., Cynthia A. Lien, M.D., John J. Savarese, M.D., Virginia D. Schmith, Ph.D.

Anesthesiology. June 2018: 128(6):1107–1116

DOI: https://doi.org/10.1097/ALN.0000000000002157

Published: June 2018

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Articles

Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression

Margot Roozekrans, M.D., Rutger van der Schrier, M.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D.

Anesthesiology. May 2018: 128(5):932–942

DOI: https://doi.org/10.1097/ALN.0000000000002138

Published: May 2018

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Articles

Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy

Werner ten Hoope, M.D., Markus W. Hollmann, M.D., Ph.D., Kora de Bruin, Hein J. Verberne, M.D., Ph.D., Arie O. Verkerk, Ph.D., Hanno L. Tan, M.D., Ph.D., Camiel Verhamme, M.D., Ph.D., Janneke Horn, M.D., Ph.D., Marcel Rigaud, M.D., Susanne Picardi, M.D., Philipp Lirk, M.D., Ph.D.

Anesthesiology. March 2018: 128(3):609–619

DOI: https://doi.org/10.1097/ALN.0000000000002035

Published: March 2018

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Articles

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics–Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose

Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Beatrijs I. Valk, B.Sc., Douglas J. Eleveld, Ph.D., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Thomas Chou, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc.

Anesthesiology. July 2017: 127(1):20–35

DOI: https://doi.org/10.1097/ALN.0000000000001662

Published: July 2017

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Articles

An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Hugo Vereecke, M.D., Ph.D., Anthony R. Absalom, M.D., Ph.D., Erik Olofsen, M.Sc., Jaap Vuyk, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.

Anesthesiology. June 2017: 126(6):1005–1018

DOI: https://doi.org/10.1097/ALN.0000000000001634

Published: June 2017

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Articles

Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development

Vishvarani Wanigasekera, D.Phil., Melvin Mezue, D.Phil., Jesper Andersson, Ph.D., Yazhuo Kong, Ph.D., Irene Tracey, D.Phil.

Anesthesiology. January 2016: 124(1):159–168

DOI: https://doi.org/10.1097/ALN.0000000000000924

Published: January 2016

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Articles

Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy

Christian Jeleazcov, M.D., M.Sc., Harald Ihmsen, Ph.D., Teijo I. Saari, M.D., Ph.D., Doris Rohde, M.D., Jan Mell, M.D., Katharina Fröhlich, M.D., Ljubica Krajinovic, M.D., Jörg Fechner, M.D., Helmut Schwilden, M.D., Ph.D., Jürgen Schüttler, M.D.

Anesthesiology. January 2016: 124(1):56–68

DOI: https://doi.org/10.1097/ALN.0000000000000937

Published: January 2016

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Articles

A Response Surface Model Approach for Continuous Measures of Hypnotic and Analgesic Effect during Sevoflurane–Remifentanil Interaction: Quantifying the Pharmacodynamic Shift Evoked by Stimulation

Bjorn Heyse, M.D., Johannes H. Proost, Pharm.D., Ph.D., Laura N. Hannivoort, M.D., Douglas J. Eleveld, Ph.D., Martin Luginbühl, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., Hugo E. M. Vereecke, M.D., Ph.D.

Anesthesiology. June 2014: 120(6):1390–1399

DOI: https://doi.org/10.1097/ALN.0000000000000180

Published: June 2014

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Articles

Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study

Alana M. Flexman, M.D., Harvey Wong, Ph.D., K. Wayne Riggs, Ph.D., Tina Shih, M.D., Paul A. Garcia, M.D., Susana Vacas, M.D., Pekka O. Talke, M.D.

Anesthesiology. May 2014: 120(5):1118–1125

DOI: https://doi.org/10.1097/ALN.0000000000000141

Published: May 2014

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Articles

Resuscitation with Lipid Emulsion: Dose-dependent Recovery from Cardiac Pharmacotoxicity Requires a Cardiotonic Effect

Michael R. Fettiplace, M.S., Belinda S. Akpa, Ph.D., Richard Ripper, C.V.T., Brian Zider, B.S., Jason Lang, B.S., Israel Rubinstein, M.D., Guy Weinberg, M.D.

Anesthesiology. April 2014: 120(4):915–925

DOI: https://doi.org/10.1097/ALN.0000000000000142

Published: April 2014

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NARROW

Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

Ketamine Psychedelic and Antinociceptive Effects Are Connected

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine

Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine

Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part I. Pharmacokinetics and Clinical Pharmacodynamics

Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part II. Pharmacodynamics of Electroencephalogram Effects

Influence of St. John’s Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial

Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy

Where’s the Beef?: How Much Can We Skimp on Pharmacokinetic–Pharmacodynamic Data?

Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression

Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics–Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose

An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development

Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy

A Response Surface Model Approach for Continuous Measures of Hypnotic and Analgesic Effect during Sevoflurane–Remifentanil Interaction: Quantifying the Pharmacodynamic Shift Evoked by Stimulation

Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study

Resuscitation with Lipid Emulsion: Dose-dependent Recovery from Cardiac Pharmacotoxicity Requires a Cardiotonic Effect

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