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Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses

Stephan G. Frangakis, M.D., Ph.D., Mark MacEachern, M.L.I.S., T. Adam Akbar, M.D., Christian Bolton, M.D., Victor Lin, D.O., Ph.D., Albert V. Smith, Ph.D., Chad M. Brummett, M.D., Mark C. Bicket, M.D., Ph.D.

Anesthesiology. December 2023: 139(6):827–839

https://doi.org/10.1097/ALN.0000000000004677

Published: December 2023

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Articles

Opioid-free anesthesia protocol on the early quality of recovery after major surgery (SOFA trial): A randomized clinical trial

Maxime Léger, M.D., Ph.D., Tristan Perrault, M.D., Solène Pessiot-Royer, M.D., Elsa Parot-Schinkel, M.D., Fabienne Costerousse, M.D., Emmanuel Rineau, M.D., Ph.D., Sigismond Lasocki, M.D., Ph.D.

Anesthesiology. November 2023: 10.1097/ALN.0000000000004840

https://doi.org/10.1097/ALN.0000000000004840

Published: November 2023

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Articles

Brainstem Modulation of Nociception by Periaqueductal Gray Neurons Expressing the μ-Opioid Receptor in Mice

Eileen Nguyen, M.D., Ph.D., Michael C. Chiang, M.D., Ph.D., Catherine Nguyen, B.S., Sarah E. Ross, Ph.D.

Anesthesiology. October 2023: 139(4):462–475

https://doi.org/10.1097/ALN.0000000000004668

Published: October 2023

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Articles

Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot Study

Evan D. Kharasch, M.D., Ph.D., L. Michael Brunt, M.D., Jane Blood, R.N., Helga Komen, M.D.

Anesthesiology. October 2023: 139(4):405–419

https://doi.org/10.1097/ALN.0000000000004663

Published: October 2023

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Articles

Analgesic Effectiveness of Motor-sparing Nerve Blocks for Total Knee Arthroplasty: A Network Meta-analysis

Nasir Hussain, M.D., M.Sc., Richard Brull, M.D., F.R.C.P.C., Chris Vannabouathong, M.Sc., Christopher Robinson, M.D., Steven Zhou, M.D., Ryan S. D’Souza, M.D., Tamara Sawyer, M.L.I.S., Abdullah Sulieman Terkawi, M.D., M.S.(Epi), Faraj W. Abdallah, M.D., M.Sc.

Anesthesiology. October 2023: 139(4):444–461

https://doi.org/10.1097/ALN.0000000000004667

Published: October 2023

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Articles

Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest

Maarten van Lemmen, B.Sc., Jeffrey Florian, Ph.D., Zhihua Li, Ph.D., Monique van Velzen, Ph.D., Eveline van Dorp, M.D., Ph.D., Marieke Niesters, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, Ph.D., Rutger van der Schrier, M.D., David G. Strauss, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. September 2023: 139(3):342–353

https://doi.org/10.1097/ALN.0000000000004622

Published: September 2023

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Articles

Best Practice Alerts Informed by Inpatient Opioid Intake to Reduce Opioid Prescribing after Surgery (PRIOR): A Cluster Randomized Multiple Crossover Trial

Megan L. Rolfzen, M.D., Abraham Wick, Pharm.D., Edward J. Mascha, Ph.D., Karan Shah, M.S., Martin Krause, M.D., Ana Fernandez-Bustamante, M.D., Ph.D., Jean S. Kutner, M.D., M.S.P.H., P. Michael Ho, M.D., Ph.D., F.A.C.C., Daniel I. Sessler, M.D., Karsten Bartels, M.D., Ph.D., M.B.A.

Anesthesiology. August 2023: 139(2):186–196

https://doi.org/10.1097/ALN.0000000000004607

Published: August 2023

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Articles

Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers

Konrad Meissner, M.D., Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D., Christine Göpfert, M.D., Jane Blood, R.N., B.S.N., Johannes Wieditz, Ph.D., Evan D. Kharasch, M.D., Ph.D.

Anesthesiology. July 2023: 139(1):16–34

https://doi.org/10.1097/ALN.0000000000004567

Published: July 2023

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Articles

Phosphorylated Upstream Frameshift 1–dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia–like Behavior in Rats

Ming-Chun Hsieh, Ph.D., Cheng-Yuan Lai, Ph.D., Chou-Ming Yeh, M.D., Ph.D., Po-Sheng Yang, M.D., Ph.D., Jen-Kun Cheng, M.D., Ph.D., Hsueh-Hsiao Wang, Ph.D., Kuan-Hung Lin, Ph.D., Siao-Tong Nie, U.G., Tzer-Bin Lin, Ph.D., Hsien-Yu Peng, Ph.D.

Anesthesiology. June 2023: 138(6):634–655

https://doi.org/10.1097/ALN.0000000000004550

Published: June 2023

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Articles

Uncoupling Pain and Opioid Use after Surgery

Karim Shiraz Ladha, M.D., M.Sc., Kristin L. Schreiber, M.D., Ph.D.

Anesthesiology. May 2023: 138(5):457–459

https://doi.org/10.1097/ALN.0000000000004552

Published: May 2023

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Articles

Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study

Kai Kuck, Ph.D., Bhiken I. Naik, M.B.B.Ch., M.S.C.R., Karen B. Domino, M.D., M.P.H., Karen L. Posner, Ph.D., Leif Saager, M.D., Ami R. Stuart, Ph.D., Ken B. Johnson, M.D., Salome B. Alpert, Ph.D., Marcel E. Durieux, M.D., Ph.D., Anik K. Sinha, M.S., Chad M. Brummett, M.D., Michael F. Aziz, M.D., Kenneth C. Cummings, III, M.D., John G. Gaudet, M.D., Andrea Kurz, M.D., Mienke Rijsdijk, M.D., Ph.D., Jonathan P. Wanderer, M.D., Nathan L. Pace, M.D., M.Stat., the Multicenter Perioperative Outcomes Group Enhanced Observation Study Investigator Group for the Multicenter Perioperative Outcomes Group Enhanced Observation Study Collaborator Group, Mitchell F. Berman, M.D., M.P.H., Beatriz Raposo Corradini, M.S., Shawn L. Mincer, M.S.W, Sydney E. Rose, M.D., Wilton A. van Klei, M.D., Ph.D., David A. Edwards, M.D., Ph.D., Olivia O.A. Lamers, M.D., Michelle T. Vaughn, M.P.H.

Anesthesiology. May 2023: 138(5):462–476

https://doi.org/10.1097/ALN.0000000000004510

Published: May 2023

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Articles

Carrying Cargo: Preoperative Risk Factors for Persistent Postop Pain & Opioid Use

Holly B. Ende, James P. Rathmell, Jonathan P. Wanderer

Anesthesiology. May 2023: 138(5):A17

https://doi.org/10.1097/ALN.0000000000004564

Published: May 2023

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Articles

Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

Pieter Simons, M.D., Rutger van der Schrier, M.D., Maarten van Lemmen, B.Sc., Simone Jansen, M.D., Kiki W.K. Kuijpers, B.Sc., Monique van Velzen, Ph.D., Elise Sarton, M.D., Ph.D., Todd Nicklas, M.S.N., Cathy Michalsky, M.Sc., Mark A. Demitrack, M.D., Michael Fossler, Pharm.D., Ph.D., F.C.P., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D. Ph.D.

Anesthesiology. March 2023: 138(3):249–263

https://doi.org/10.1097/ALN.0000000000004473

Published: March 2023

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Articles

Nonopioid Analgesic Prescriptions Filled after Surgery among Older Adults in Ontario, Canada: A Population-based Cohort Study

Naheed K. Jivraj, M.B.B.S., M.Sc., Karim S. Ladha, M.D., M.Sc., Akash Goel, M.D., M.Sc., Andrea Hill, Ph.D., Duminda N. Wijeysundera, M.D., Ph.D., Brian T. Bateman, M.D., M.Sc., Mark Neuman, M.D., M.Sc., Hannah Wunsch, M.D., M.Sc.

Anesthesiology. February 2023: 138(2):195–207

https://doi.org/10.1097/ALN.0000000000004443

Published: February 2023

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Articles

Opioids: The Elephant in the Room

Alan Jay Schwartz, M.D., M.S.Ed.

Anesthesiology. December 2022: 137(6):754–755

https://doi.org/10.1097/ALN.0000000000004358

Published: December 2022

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Articles

No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone, and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty

Felipe Muñoz-Leyva, M.D., James M. Jack, M.B.B.S., Anuj Bhatia, M.D., F.R.C.P.C., Ki Jinn Chin, M.B.B.S. (Hon), M.Med., F.A.N.Z.C.A., F.R.C.P.C., Rajiv Gandhi, M.D., M.S., F.R.C.S.C., Anahi Perlas, M.D., F.R.C.P.C., Rongyu Jin, M.D., Vincent Chan, M.D., F.R.C.P.C.

Anesthesiology. October 2022: 137(4):459–470

https://doi.org/10.1097/ALN.0000000000004326

Published: October 2022

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Articles

Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression

Hyke Algera, M.D., Rutger van der Schrier, M.D., David Cavalla, Ph.D., Monique van Velzen, Ph.D., Margot Roozekrans, M.D., Ph.D., Alison McMorn, Ph.D., Michael Snape, Ph.D., Joseph P. Horrigan, M.D., Stuart Evans, M.A., Bernard Kiernan, Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. October 2022: 137(4):446–458

https://doi.org/10.1097/ALN.0000000000004324

Published: October 2022

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Articles

The Early Days: Do Immediate Perioperative Opioid Prescribing Practices Affect Long-Term Opioid Utilization?

Holly B. Ende, James P. Rathmell, Jonathan P. Wanderer

Anesthesiology. August 2022: 137(2):A17

https://doi.org/10.1097/ALN.0000000000004305

Published: August 2022

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Articles

Postoperative Opioid Prescribing: Finding the Balance

Daniel I. McIsaac, M.D., M.P.H., F.R.C.P.C., Karim S. Ladha, M.D., M.Sc.

Anesthesiology. August 2022: 137(2):131–133

https://doi.org/10.1097/ALN.0000000000004297

Published: August 2022

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Articles

Surgeon Variation in Perioperative Opioid Prescribing and Medium- or Long-term Opioid Utilization after Total Knee Arthroplasty: A Cross-sectional Analysis

Xi Cen, Ph.D., Anupam B. Jena, M.D., Ph.D., Sean Mackey, M.D., Ph.D., Eric C. Sun, M.D., Ph.D.

Anesthesiology. August 2022: 137(2):151–162

https://doi.org/10.1097/ALN.0000000000004259

Published: August 2022

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NARROW

Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses

Opioid-free anesthesia protocol on the early quality of recovery after major surgery (SOFA trial): A randomized clinical trial

Brainstem Modulation of Nociception by Periaqueductal Gray Neurons Expressing the μ-Opioid Receptor in Mice

Intraoperative Methadone in Next-day Discharge Outpatient Surgery: A Randomized, Double-blinded, Dose-finding Pilot Study

Analgesic Effectiveness of Motor-sparing Nerve Blocks for Total Knee Arthroplasty: A Network Meta-analysis

Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest

Best Practice Alerts Informed by Inpatient Opioid Intake to Reduce Opioid Prescribing after Surgery (PRIOR): A Cluster Randomized Multiple Crossover Trial

Morphine and Hydromorphone Effects, Side Effects, and Variability: A Crossover Study in Human Volunteers

Phosphorylated Upstream Frameshift 1–dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia–like Behavior in Rats

Uncoupling Pain and Opioid Use after Surgery

Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study

Carrying Cargo: Preoperative Risk Factors for Persistent Postop Pain & Opioid Use

Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

Nonopioid Analgesic Prescriptions Filled after Surgery among Older Adults in Ontario, Canada: A Population-based Cohort Study

Opioids: The Elephant in the Room

No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone, and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty

Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression

The Early Days: Do Immediate Perioperative Opioid Prescribing Practices Affect Long-Term Opioid Utilization?

Postoperative Opioid Prescribing: Finding the Balance

Surgeon Variation in Perioperative Opioid Prescribing and Medium- or Long-term Opioid Utilization after Total Knee Arthroplasty: A Cross-sectional Analysis

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