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Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling

Swati Agarwal, Ph.D., Michele L. Schaefer, Ph.D., Caroline Krall, B.V.M.&S., M.Sc., Roger A. Johns, M.D., M.H.S., Ph.D.

Anesthesiology. August 2022: 137(2):212–231

DOI: https://doi.org/10.1097/ALN.0000000000004264

Published: August 2022

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Articles

A Neural Circuit from the Paraventricular Thalamus to the Bed Nucleus of the Stria Terminalis for the Regulation of States of Consciousness during Sevoflurane Anesthesia in Mice

Jia-Yan Li, M.D., Ph.D., Shao-Jie Gao, M.M., Ran-Ran Li, Ph.D., Wei Wang, Ph.D., Jia Sun, M.M., Long-Qing Zhang, M.M., Jia-Yi Wu, M.M., Dai-Qiang Liu, M.D., Ph.D., Pei Zhang, Ph.D., Bo Tian, M.D., Ph.D., Wei Mei, M.D., Ph.D.

Anesthesiology. May 2022: 136(5):709–731

DOI: https://doi.org/10.1097/ALN.0000000000004195

Published: May 2022

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Articles

Slick Potassium Channels Control Pain and Itch in Distinct Populations of Sensory and Spinal Neurons in Mice

Cathrin Flauaus, R.Ph., Patrick Engel, R.Ph., Fangyuan Zhou, M.S., Jonas Petersen, Ph.D., Peter Ruth, Ph.D., Robert Lukowski, Ph.D., Achim Schmidtko, M.D., Ph.D., Ruirui Lu, M.D., Ph.D.

Anesthesiology. May 2022: 136(5):802–822

DOI: https://doi.org/10.1097/ALN.0000000000004163

Published: May 2022

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Articles

Journal-related Activities and Other Special Activities at the 2021 American Society of Anesthesiologists Meeting

Michael J. Avram, Ph.D., Deborah J. Culley, M.D., Evan D. Kharasch, M.D., Ph.D., Jerrold H. Levy, M.D., F.C.C.M., Martin J. London, M.D.

Anesthesiology. October 2021: 135(4):576–584

DOI: https://doi.org/10.1097/ALN.0000000000003949

Published: October 2021

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Articles

Anesthesia Mechanisms: A Patchwork Quilt rather than a Wet Blanket?

Logan Voss, Ph.D., Jamie W. Sleigh, M.D.

Anesthesiology. October 2021: 135(4):568–569

DOI: https://doi.org/10.1097/ALN.0000000000003879

Published: October 2021

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Articles

Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia

Eric D. Melonakos, Ph.D., Morgan J. Siegmann, B.S., Charles Rey, B.S., Christopher O’Brien, B.S., Ksenia K. Nikolaeva, M.S., Ken Solt, M.D., Christa J. Nehs, Ph.D.

Anesthesiology. October 2021: 135(4):633–648

DOI: https://doi.org/10.1097/ALN.0000000000003883

Published: October 2021

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Articles

GABAergic Neurons in the Dorsal–Intermediate Lateral Septum Regulate Sleep–Wakefulness and Anesthesia in Mice

Di Wang, M.D., Qingchen Guo, Ph.D., Yu Zhou, M.D., Zheng Xu, M.D., Su-Wan Hu, M.D., Xiang-Xi Kong, M.D., Yu-Mei Yu, M.D., Jun-Xia Yang, M.D., Hongxing Zhang, M.D., Ph.D., Hai-Lei Ding, M.D., Ph.D., Jun-Li Cao, M.D., Ph.D.

Anesthesiology. September 2021: 135(3):463–481

DOI: https://doi.org/10.1097/ALN.0000000000003868

Published: September 2021

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Articles

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., F.R.S.C.

Anesthesiology. July 2021: 135(1):18–30

DOI: https://doi.org/10.1097/ALN.0000000000003798

Published: July 2021

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Articles

Automated Nerve Monitoring in Shoulder Arthroplasty: A Prospective Randomized Controlled Study

Jason Chui, M.B.Ch.B., M.Sc., F.A.N.Z.C.A., F.H.K.C.A., F.H.K.A.M., Moaz B. Y. Chohan, M.D., John M. Murkin, M.D., F.R.C.P.C., Maxim Rachinsky, M.D., F.R.C.P.C., Shalini Dhir, M.D., F.R.C.P.C., George S. Athwal, M.D., F.R.C.S.C., Kenneth J. Faber, M.D., M.H.P.E., F.R.C.S.C., Darren Drosdowech, M.D., F.R.C.S.C.

Anesthesiology. July 2021: 135(1):83–94

DOI: https://doi.org/10.1097/ALN.0000000000003797

Published: July 2021

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Articles

Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice

Wenling Zhao, M.D., Shuai Zhao, M.D., Tao Zhu, M.D., Mengchan Ou, M.D., Donghang Zhang, M.D., Huaiqiang Sun, Ph.D., Jin Liu, M.D., Ph.D., Xiangdong Chen, M.D., Ph.D., Hugh C. Hemmings, Jr., M.D., Ph.D., Cheng Zhou, Ph.D.

Anesthesiology. July 2021: 135(1):122–135

DOI: https://doi.org/10.1097/ALN.0000000000003803

Published: July 2021

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Articles

Mitochondrial Function and Anesthetic Sensitivity in the Mouse Spinal Cord

Christian B. Woods, B.S., Kira A. Spencer, Ph.D., Sangwook Jung, Ph.D., Hailey M. Worstman, B.A., Jan-Marino Ramirez, Ph.D., Philip G. Morgan, M.D., Margaret M. Sedensky, M.D.

Anesthesiology. June 2021: 134(6):901–914

DOI: https://doi.org/10.1097/ALN.0000000000003794

Published: June 2021

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Articles

Neurons in the Nonhuman Primate Amygdala and Dorsal Anterior Cingulate Cortex Signal Aversive Memory Formation under Sedation

Nir Samuel, M.D., Ph.D., Eilat Kahana, M.D., Ph.D., Aryeh Taub, Ph.D., Tamar Reitich-Stolero, M.Sc., Rony Paz, Ph.D., Aeyal Raz, M.D., Ph.D.

Anesthesiology. May 2021: 134(5):734–747

DOI: https://doi.org/10.1097/ALN.0000000000003732

Published: May 2021

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Articles

Positive Regulatory Domain I–binding Factor 1 Mediates Peripheral Nerve Injury–induced Nociception in Mice by Repressing Kv4.3 Channel Expression

Cunjin Wang, M.D., Ph.D., Yuchen Pan, M.D., Wenwen Zhang, Ph.D., Ying Chen, Ph.D., Chuhan Li, B.S., Fang Zhao, Ph.D., Thomas Behnisch, Ph.D.

Anesthesiology. March 2021: 134(3):435–456

DOI: https://doi.org/10.1097/ALN.0000000000003654

Published: March 2021

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Articles

Spinal Anesthesia Reduces Myocardial Ischemia–triggered Ventricular Arrhythmias by Suppressing Spinal Cord Neuronal Network Interactions in Pigs

Yukiko Omura, M.D., Jasmine P. Kipke, B.S., Siamak Salavatian, Ph.D., Andrew Shea Afyouni, B.S., Christian Wooten, B.A., Robert F. Herkenham, M.S.E., Uri Maoz, Ph.D., Elnaz Lashgari, M.S., Erica A. Dale, Ph.D., Kimberly Howard-Quijano, M.D., M.S., Aman Mahajan, M.D., Ph.D.

Anesthesiology. March 2021: 134(3):405–420

DOI: https://doi.org/10.1097/ALN.0000000000003662

Published: March 2021

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Articles

Fast-spiking Interneurons Contribute to Propofol-induced Facilitation of Firing Synchrony in Pyramidal Neurons of the Rat Insular Cortex

Yuko Koyanagi, D.D.S., Ph.D., Yoshiyuki Oi, M.D., Ph.D., Masayuki Kobayashi, D.D.S., Ph.D.

Anesthesiology. February 2021: 134(2):219–233

DOI: https://doi.org/10.1097/ALN.0000000000003653

Published: February 2021

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Articles

L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons

Daisuke Uta, Ph.D., Kohei Koga, Ph.D., Hidemasa Furue, Ph.D., Keiji Imoto, M.D., Ph.D., Megumu Yoshimura, M.D., Ph.D.

Anesthesiology. January 2021: 134(1):88–102

DOI: https://doi.org/10.1097/ALN.0000000000003596

Published: January 2021

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Articles

Acid-sensing Ion Channel 3 Overexpression in Incisions Regulated by Nerve Growth Factor Participates in Postoperative Nociception in Rats

Hao Li, M.D., Huiping Li, M.D., Ph.D., Jing Cheng, M.D., Xicheng Liu, M.D., Zhongjun Zhang, M.D., Chaoran Wu, M.D., Ph.D.

Anesthesiology. December 2020: 133(6):1244–1259

DOI: https://doi.org/10.1097/ALN.0000000000003576

Published: December 2020

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Articles

Cryoneurolysis and Percutaneous Peripheral Nerve Stimulation to Treat Acute Pain: A Narrative Review

Brian M. Ilfeld, M.D., M.S., John J. Finneran, IV, M.D.

Anesthesiology. November 2020: 133(5):1127–1149

DOI: https://doi.org/10.1097/ALN.0000000000003532

Published: November 2020

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Articles

Volatile Anesthetics Activate a Leak Sodium Conductance in Retrotrapezoid Nucleus Neurons to Maintain Breathing during Anesthesia in Mice

Yaoxin Yang, M.D., Mengchan Ou, M.D., Jin Liu, M.D., Wenling Zhao, M.D., Lamu Zhuoma, M.D., Yan Liang, M.B., Tao Zhu, M.D., Daniel K. Mulkey, Ph.D., Cheng Zhou, Ph.D.

Anesthesiology. October 2020: 133(4):824–838

DOI: https://doi.org/10.1097/ALN.0000000000003493

Published: October 2020

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Articles

Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics

Gregory S. Wirak, B.S., Christopher V. Gabel, Ph.D., Christopher W. Connor, M.D., Ph.D.

Anesthesiology. September 2020: 133(3):569–582

DOI: https://doi.org/10.1097/ALN.0000000000003335

Published: September 2020

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NARROW

Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling

A Neural Circuit from the Paraventricular Thalamus to the Bed Nucleus of the Stria Terminalis for the Regulation of States of Consciousness during Sevoflurane Anesthesia in Mice

Slick Potassium Channels Control Pain and Itch in Distinct Populations of Sensory and Spinal Neurons in Mice

Journal-related Activities and Other Special Activities at the 2021 American Society of Anesthesiologists Meeting

Anesthesia Mechanisms: A Patchwork Quilt rather than a Wet Blanket?

Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia

GABAergic Neurons in the Dorsal–Intermediate Lateral Septum Regulate Sleep–Wakefulness and Anesthesia in Mice

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Automated Nerve Monitoring in Shoulder Arthroplasty: A Prospective Randomized Controlled Study

Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice

Mitochondrial Function and Anesthetic Sensitivity in the Mouse Spinal Cord

Neurons in the Nonhuman Primate Amygdala and Dorsal Anterior Cingulate Cortex Signal Aversive Memory Formation under Sedation

Positive Regulatory Domain I–binding Factor 1 Mediates Peripheral Nerve Injury–induced Nociception in Mice by Repressing Kv4.3 Channel Expression

Spinal Anesthesia Reduces Myocardial Ischemia–triggered Ventricular Arrhythmias by Suppressing Spinal Cord Neuronal Network Interactions in Pigs

Fast-spiking Interneurons Contribute to Propofol-induced Facilitation of Firing Synchrony in Pyramidal Neurons of the Rat Insular Cortex

L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons

Acid-sensing Ion Channel 3 Overexpression in Incisions Regulated by Nerve Growth Factor Participates in Postoperative Nociception in Rats

Cryoneurolysis and Percutaneous Peripheral Nerve Stimulation to Treat Acute Pain: A Narrative Review

Volatile Anesthetics Activate a Leak Sodium Conductance in Retrotrapezoid Nucleus Neurons to Maintain Breathing during Anesthesia in Mice

Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics

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