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Articles

Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System

Andrew S. Chang, M.S., Gregory S. Wirak, Ph.D., Duan Li, Ph.D., Christopher V. Gabel, Ph.D., Christopher W. Connor, M.D., Ph.D.

Anesthesiology. July 2023: 139(1):49–62

https://doi.org/10.1097/ALN.0000000000004579

Published: July 2023

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Articles

TREK-1 and TREK-2 Knockout Mice Are Not Resistant to Halothane or Isoflurane

Kira A. Spencer, Ph.D., Christian B. Woods, B.S., Hailey M. Worstman, B.A., Simon C. Johnson, Ph.D., Jan-Marino Ramirez, Ph.D., Philip G. Morgan, M.D., Margaret M. Sedensky, M.D.

Anesthesiology. July 2023: 139(1):63–76

https://doi.org/10.1097/ALN.0000000000004577

Published: July 2023

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Articles

Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na + /K + -ATPase Impairment in the Rat Brain

Clemens Reiffurth, Ph.D., Nikolaus Berndt, Ph.D., Adrian Gonzalez Lopez, Ph.D., Karl Schoknecht, M.D., Ph.D., Richard Kovács, Ph.D., Mathilde Maechler, Mirja grote Lambers, Jens P. Dreier, M.D., Alon Friedman, M.D., Ph.D., Claudia Spies, M.D., Agustin Liotta, M.D.

Anesthesiology. June 2023: 138(6):611–623

https://doi.org/10.1097/ALN.0000000000004553

Published: June 2023

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Articles

Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling

Swati Agarwal, Ph.D., Michele L. Schaefer, Ph.D., Caroline Krall, B.V.M.&S., M.Sc., Roger A. Johns, M.D., M.H.S., Ph.D.

Anesthesiology. August 2022: 137(2):212–231

https://doi.org/10.1097/ALN.0000000000004264

Published: August 2022

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Articles

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., F.R.S.C.

Anesthesiology. July 2021: 135(1):18–30

https://doi.org/10.1097/ALN.0000000000003798

Published: July 2021

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Articles

Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice

Wenling Zhao, M.D., Shuai Zhao, M.D., Tao Zhu, M.D., Mengchan Ou, M.D., Donghang Zhang, M.D., Huaiqiang Sun, Ph.D., Jin Liu, M.D., Ph.D., Xiangdong Chen, M.D., Ph.D., Hugh C. Hemmings, Jr., M.D., Ph.D., Cheng Zhou, Ph.D.

Anesthesiology. July 2021: 135(1):122–135

https://doi.org/10.1097/ALN.0000000000003803

Published: July 2021

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Articles

Mitochondrial Function and Anesthetic Sensitivity in the Mouse Spinal Cord

Christian B. Woods, B.S., Kira A. Spencer, Ph.D., Sangwook Jung, Ph.D., Hailey M. Worstman, B.A., Jan-Marino Ramirez, Ph.D., Philip G. Morgan, M.D., Margaret M. Sedensky, M.D.

Anesthesiology. June 2021: 134(6):901–914

https://doi.org/10.1097/ALN.0000000000003794

Published: June 2021

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Articles

Forebrain Acetylcholine Modulates Isoflurane and Ketamine Anesthesia in Adult Mice

L. Stan Leung, Ph.D., Liangwei Chu, M.D., M.Sc., Marco A. M. Prado, Ph.D., Vania F. Prado, Ph.D.

Anesthesiology. April 2021: 134(4):588–606

https://doi.org/10.1097/ALN.0000000000003713

Published: April 2021

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Articles

Competitive Interactions between Halothane and Isoflurane at the Carotid Body and TASK Channels

Jaideep J. Pandit, D.Phil., Nicky Huskens, D.Phil., Peadar B. O’Donohoe, D.Phil., Philip J. Turner, Ph.D., Keith J. Buckler, Ph.D.

Anesthesiology. November 2020: 133(5):1046–1059

https://doi.org/10.1097/ALN.0000000000003520

Published: November 2020

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Articles

Volatile Anesthetics Activate a Leak Sodium Conductance in Retrotrapezoid Nucleus Neurons to Maintain Breathing during Anesthesia in Mice

Yaoxin Yang, M.D., Mengchan Ou, M.D., Jin Liu, M.D., Wenling Zhao, M.D., Lamu Zhuoma, M.D., Yan Liang, M.B., Tao Zhu, M.D., Daniel K. Mulkey, Ph.D., Cheng Zhou, Ph.D.

Anesthesiology. October 2020: 133(4):824–838

https://doi.org/10.1097/ALN.0000000000003493

Published: October 2020

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Articles

Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats

Gregory A. Chinn, M.D., Ph.D., Jennifer M. Sasaki Russell, Ph.D., Nicole A. Yabut, B.S., Deenu Maharjan, M.D., Jeffrey W. Sall, Ph.D., M.D.

Anesthesiology. October 2020: 133(4):852–866

https://doi.org/10.1097/ALN.0000000000003437

Published: October 2020

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Articles

Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice

Michele L. Schaefer, Ph.D., Patric J. Perez, B.A., Meina Wang, Ph.D., Christy Gray, M.D., Ph.D., Caroline Krall, B.V.M.&S., M.Sc., Xiaoning Sun, B.A., Elizabeth Hunter, B.S., John Skinner, B.S., Roger A. Johns, M.D., M.H.S., Ph.D.

Anesthesiology. October 2020: 133(4):812–823

https://doi.org/10.1097/ALN.0000000000003482

Published: October 2020

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Articles

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity

Zachariah P. G. Olufs, B.S., Barry Ganetzky, Ph.D., David A. Wassarman, Ph.D., Misha Perouansky, M.D.

Anesthesiology. October 2020: 133(4):839–851

https://doi.org/10.1097/ALN.0000000000003486

Published: October 2020

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Articles

End-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents

Philip J. Peyton, M.D., Ph.D., M.B.B.S., F.A.N.Z.C.A., Jan Hendrickx, M.D., Ph.D., Rene J. E. Grouls, Pharm.D., Ph.D., Andre Van Zundert, M.D., Ph.D., F.R.C.A., E.D.R.A., F.A.N.Z.C.A., Andre De Wolf, M.D.

Anesthesiology. September 2020: 133(3):534–547

https://doi.org/10.1097/ALN.0000000000003445

Published: September 2020

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Articles

Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics

Gregory S. Wirak, B.S., Christopher V. Gabel, Ph.D., Christopher W. Connor, M.D., Ph.D.

Anesthesiology. September 2020: 133(3):569–582

https://doi.org/10.1097/ALN.0000000000003335

Published: September 2020

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Articles

Anesthesia as Decoupling?

Andrew E. Hudson, M.D., Ph.D.

Anesthesiology. July 2020: 133(1):11–12

https://doi.org/10.1097/ALN.0000000000003366

Published: July 2020

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Articles

Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia

Mehraj R. Awal, Ph.D., Gregory S. Wirak, B.S., Christopher V. Gabel, Ph.D., Christopher W. Connor, M.D., Ph.D.

Anesthesiology. July 2020: 133(1):133–144

https://doi.org/10.1097/ALN.0000000000003304

Published: July 2020

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Articles

Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus

Qun Li, Ph.D., Reilley P. Mathena, B.S., Jing Xu, M.D., O’Rukevwe N. Eregha, B.A., Jieqiong Wen, B.S., Cyrus D. Mintz, M.D., Ph.D.

Anesthesiology. November 2019: 131(5):1077–1091

https://doi.org/10.1097/ALN.0000000000002904

Published: November 2019

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Articles

Population Kinetics of 0.9% Saline Distribution in Hemorrhaged Awake and Isoflurane-anesthetized Volunteers

Joakim Nyberg, M.Sc., Ph.D., Husong Li, M.D., Ph.D., Pehr Wessmark, M.Sc., Viktor Winther, M.Sc., Donald S. Prough, M.D., Michael P. Kinsky, M.D., Christer H. Svensén, M.D., Ph.D.

Anesthesiology. September 2019: 131(3):501–511

https://doi.org/10.1097/ALN.0000000000002816

Published: September 2019

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Articles

Syntaxin1A Neomorphic Mutations Promote Rapid Recovery from Isoflurane Anesthesia in Drosophila melanogaster

Michael Troup, Ph.D., Oressia H. Zalucki, Ph.D., Benjamin D. Kottler, Ph.D., Shanker Karunanithi, Ph.D., Victor Anggono, Ph.D., Bruno van Swinderen, Ph.D.

Anesthesiology. September 2019: 131(3):555–568

https://doi.org/10.1097/ALN.0000000000002850

Published: September 2019

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NARROW

Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System

TREK-1 and TREK-2 Knockout Mice Are Not Resistant to Halothane or Isoflurane

Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na + /K + -ATPase Impairment in the Rat Brain

Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice

Mitochondrial Function and Anesthetic Sensitivity in the Mouse Spinal Cord

Forebrain Acetylcholine Modulates Isoflurane and Ketamine Anesthesia in Adult Mice

Competitive Interactions between Halothane and Isoflurane at the Carotid Body and TASK Channels

Volatile Anesthetics Activate a Leak Sodium Conductance in Retrotrapezoid Nucleus Neurons to Maintain Breathing during Anesthesia in Mice

Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats

Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity

End-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents

Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics

Anesthesia as Decoupling?

Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia

Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus

Population Kinetics of 0.9% Saline Distribution in Hemorrhaged Awake and Isoflurane-anesthetized Volunteers

Syntaxin1A Neomorphic Mutations Promote Rapid Recovery from Isoflurane Anesthesia in Drosophila melanogaster

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