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Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., F.R.S.C.

Anesthesiology. July 2021: 135(1):18–30

DOI: https://doi.org/10.1097/ALN.0000000000003798

Published: July 2021

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Articles

Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation

Agnieszka Czopik, Ph.D., Xiaoyi Yuan, Ph.D., Scott E. Evans, M.D., Holger K. Eltzschig, M.D., Ph.D.

Anesthesiology. July 2021: 135(1):15–17

DOI: https://doi.org/10.1097/ALN.0000000000003841

Published: July 2021

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Articles

Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep

Congli Zeng, M.D., Ph.D., Gabriel C. Motta-Ribeiro, Ph.D., Takuga Hinoshita, M.D., Ph.D., Marcos Adriano Lessa, M.D., Ph.D., Tilo Winkler, Ph.D., Kira Grogg, Ph.D., Nathan M. Kingston, B.S., John N. Hutchinson, Ph.D., Lynette Marie Sholl, M.D., Xiangming Fang, M.D., Ph.D., Xaralabos Varelas, Ph.D., Matthew D. Layne, Ph.D., Rebecca M. Baron, M.D., Marcos F. Vidal Melo, M.D., Ph.D.

Anesthesiology. November 2020: 133(5):1060–1076

DOI: https://doi.org/10.1097/ALN.0000000000003491

Published: November 2020

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Articles

Dexmedetomidine Exerts an Anti-inflammatory Effect via α 2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice

Rong Li, M.D., Ieng K. Lai, B.S., Jonathan Z. Pan, M.D., Ph.D., Pengbo Zhang, M.D., Ph.D., Mervyn Maze, M.B., Ch.B.

Anesthesiology. August 2020: 133(2):393–407

DOI: https://doi.org/10.1097/ALN.0000000000003390

Published: August 2020

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Articles

Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats

Doaa M. Mohamed, M.Sc., Mohammed Shaqura, Ph.D., Xiongjuan Li, M.D., Mehdi Shakibaei, Ph.D., Antje Beyer, M.D., Sascha Treskatsch, M.D., Michael Schäfer, M.D., Ph.D., Shaaban A. Mousa, Ph.D.

Anesthesiology. April 2020: 132(4):867–880

DOI: https://doi.org/10.1097/ALN.0000000000003127

Published: April 2020

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Articles

Toll-like Receptor 7 Contributes to Inflammation, Organ Injury, and Mortality in Murine Sepsis

Wenling Jian, M.D., Ph.D., Lili Gu, Ph.D., Brittney Williams, M.D., Yan Feng, M.D., Ph.D., Wei Chao, M.D., Ph.D., Lin Zou, M.D., Ph.D.

Anesthesiology. July 2019: 131(1):105–118

DOI: https://doi.org/10.1097/ALN.0000000000002706

Published: July 2019

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Articles

Inflammation Drives Pulmonary Arterial Hypertension

Neil M. Goldenberg, M.D., Ph.D., Benjamin E. Steinberg, M.D., Ph.D.

Anesthesiology. May 2019: 130(5):820–821

DOI: https://doi.org/10.1097/ALN.0000000000002561

Published: May 2019

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Articles

Biologic Impact of Mechanical Power at High and Low Tidal Volumes in Experimental Mild Acute Respiratory Distress Syndrome

Raquel S. Santos, Ph.D., Ligia de A. Maia, Ph.D., Milena V. Oliveira, M.Sc., Cíntia L. Santos, M.D., Ph.D., Lillian Moraes, Ph.D., Eliete F. Pinto, R.T., Cynthia dos S. Samary, Ph.D., Joana A. Machado, M.S., Anna Carolinna Carvalho, M.S., Marcos Vinícius de S. Fernandes, M.S., Vanessa Martins, Ph.D., Vera L. Capelozzi, M.D., Ph.D., Marcelo M. Morales, M.D., Ph.D., Thea Koch, M.D., Ph.D., Marcelo Gama de Abreu, M.D., Ph.D., Paolo Pelosi, M.D., F.E.R.S., Pedro L. Silva, Ph.D., Patricia R. M. Rocco, M.D., Ph.D.

Anesthesiology. June 2018: 128(6):1193–1206

DOI: https://doi.org/10.1097/ALN.0000000000002143

Published: June 2018

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Articles

Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein–induced Inflammation through a Vagomimetic Action in Mice

Jun Hu, M.D., Susana Vacas, M.D., Ph.D., Xiaomei Feng, M.D., Ph.D., David Lutrin, M.D., Yosuke Uchida, M.D., Ph.D., Ieng Kit Lai, B.S., Mervyn Maze, M.B.Ch.B.

Anesthesiology. May 2018: 128(5):921–931

DOI: https://doi.org/10.1097/ALN.0000000000002038

Published: May 2018

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Articles

Astrocytic N-Myc Downstream-regulated Gene–2 Is Involved in Nuclear Transcription Factor κB–mediated Inflammation Induced by Global Cerebral Ischemia

You-liang Deng, M.D., Yu-long Ma, Ph.D., Zeng-li Zhang, M.D., Li-xia Zhang, M.D., Hang Guo, Ph.D., Pei Qin, M.D., Yu-shu Hou, M.D., Zi-jun Gao, M.D., Wu-gang Hou, Ph.D.

Anesthesiology. March 2018: 128(3):574–586

DOI: https://doi.org/10.1097/ALN.0000000000002044

Published: March 2018

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Articles

One-hit Models of Ventilator-induced Lung Injury: Benign Inflammation versus Inflammation as a By-product

Dennis Lex, Ph.D., Stefan Uhlig, Ph.D.

Anesthesiology. May 2017: 126(5):909–922

DOI: https://doi.org/10.1097/ALN.0000000000001605

Published: May 2017

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Articles

Early Regional Inflammation: The Seeds of Lung Injury

Maurizio Cereda, M.D., Yi Xin, M.S.

Anesthesiology. November 2016: 125(5):838–840

DOI: https://doi.org/10.1097/ALN.0000000000001335

Published: November 2016

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Articles

Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity

Tyler J. Wellman, Ph.D., Nicolas de Prost, M.D., Ph.D., Mauro Tucci, M.D., Ph.D., Tilo Winkler, Ph.D., Rebecca M. Baron, M.D., Piotr Filipczak, Ph.D., Benjamin Raby, M.D., M.P.H., Jen-hwa Chu, Ph.D., R. Scott Harris, M.D., Guido Musch, M.D., Luiz F. dos Reis Falcao, M.D., Ph.D., Vera Capelozzi, M.D., Ph.D., Jose G. Venegas, Ph.D., Marcos F. Vidal Melo, M.D., Ph.D.

Anesthesiology. November 2016: 125(5):992–1004

DOI: https://doi.org/10.1097/ALN.0000000000001334

Published: November 2016

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Articles

Inflammation Increases Neuronal Sensitivity to General Anesthetics

Sinziana Avramescu, M.D., Ph.D., Dian-Shi Wang, M.D., Ph.D., Irene Lecker, Ph.D., William T. H. To, M.Sc., Antonello Penna, M.D., Ph.D., Paul D. Whissell, Ph.D., Lia Mesbah-Oskui, M.Sc., Richard L. Horner, Ph.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. February 2016: 124(2):417–427

DOI: https://doi.org/10.1097/ALN.0000000000000943

Published: February 2016

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Articles

Resolution of Inflammation by Resolvin D1 Is Essential for Peroxisome Proliferator–activated Receptor-γ–mediated Analgesia during Postincisional Pain Development in Type 2 Diabetes

Takayuki Saito, M.D., Maiko Hasegawa-Moriyama, M.D., Ph.D., Tae Kurimoto, B.S., Tomotsugu Yamada, M.D., Eichi Inada, M.D., Ph.D., Yuichi Kanmura, M.D., Ph.D.

Anesthesiology. December 2015: 123(6):1420–1434

DOI: https://doi.org/10.1097/ALN.0000000000000892

Published: December 2015

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Articles

Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study

Xiaodong Liu, B.Sc., M.Eng., Ph.D., Yuanyuan Tian, B.Med., M.Med., Ph.D., Zhaoyu Meng, B.Sc., M.Phil., Ph.D., Yan Chen, B.Sc., M.Sc., Ph.D., Idy H. T. Ho, B.Sc., Kwong Wai Choy, B.Sc., M.Sc., Ph.D., Peter Lichtner, Ph.D., Sunny H. Wong, M.B.Ch.B., D.Phil., M.R.C.P., Jun Yu, M.D., Ph.D., Tony Gin, M.D., F.R.C.A., F.A.N.Z.C.A., F.H.K.C.A., William K. K. Wu, M.Phil., Ph.D., F.R.C.Path., Christopher H. K. Cheng, B.Sc., Ph.D., Matthew T. V. Chan, M.B.B.S., Ph.D., F.A.N.Z.C.A., F.H.K.C.A.

Anesthesiology. October 2015: 123(4):838–850

DOI: https://doi.org/10.1097/ALN.0000000000000828

Published: October 2015

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Articles

Effect of Therapeutic Hypercapnia on Inflammatory Responses to One-lung Ventilation in Lobectomy Patients

Wei Gao, M.D., Dong-Dong Liu, M.D., Di Li, M.D., Guang-xiao Cui, M.D., Ph.D.

Anesthesiology. June 2015: 122(6):1235–1252

DOI: https://doi.org/10.1097/ALN.0000000000000627

Published: June 2015

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Articles

Effects of Ultraprotective Ventilation, Extracorporeal Carbon Dioxide Removal, and Spontaneous Breathing on Lung Morphofunction and Inflammation in Experimental Severe Acute Respiratory Distress Syndrome

Andreas Güldner, M.D., Thomas Kiss, M.D., Thomas Bluth, M.D., Christopher Uhlig, M.D., Anja Braune, M.Sc., Nadja Carvalho, Ph.D., Theresa Quast, Cand.Med., Ines Rentzsch, Ph.D., Robert Huhle, M.Sc., Peter Spieth, M.D., Torsten Richter, M.D., Felipe Saddy, M.D., Ph.D., Patricia R. M. Rocco, M.D., Ph.D., Michael Kasper, Ph.D., Thea Koch, M.D., Ph.D., Paolo Pelosi, M.D., Marcelo Gama de Abreu, M.D., M.Sc., Ph.D., D.E.S.A.

Anesthesiology. March 2015: 122(3):631–646

DOI: https://doi.org/10.1097/ALN.0000000000000504

Published: March 2015

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Articles

Blocking the Mineralocorticoid Receptor Improves Effectiveness of Steroid Treatment for Low Back Pain in Rats

Ling Ye, M.D., Wenrui Xie, Ph.D., Judith A. Strong, Ph.D., Jun-Ming Zhang, M.D., M.Sc.

Anesthesiology. September 2014: 121(3):632–643

DOI: https://doi.org/10.1097/ALN.0000000000000277

Published: September 2014

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Articles

Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing

Wiebke Kallenborn-Gerhardt, Ph.D., Ruirui Lu, M.D., Aaron Bothe, M.D., Dominique Thomas, M.Sc., Jessica Schlaudraff, Ph.D., Jana E. Lorenz, M.Sc., Nancy Lippold, M.Sc., Catherine I. Real, M.Sc., Nerea Ferreirós, Ph.D., Gerd Geisslinger, M.D., Ph.D., Domenico Del Turco, Ph.D., Achim Schmidtko, M.D., Ph.D.

Anesthesiology. August 2014: 121(2):372–382

DOI: https://doi.org/10.1097/ALN.0000000000000270

Published: August 2014

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NARROW

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation

Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep

Dexmedetomidine Exerts an Anti-inflammatory Effect via α 2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice

Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats

Toll-like Receptor 7 Contributes to Inflammation, Organ Injury, and Mortality in Murine Sepsis

Inflammation Drives Pulmonary Arterial Hypertension

Biologic Impact of Mechanical Power at High and Low Tidal Volumes in Experimental Mild Acute Respiratory Distress Syndrome

Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein–induced Inflammation through a Vagomimetic Action in Mice

Astrocytic N-Myc Downstream-regulated Gene–2 Is Involved in Nuclear Transcription Factor κB–mediated Inflammation Induced by Global Cerebral Ischemia

One-hit Models of Ventilator-induced Lung Injury: Benign Inflammation versus Inflammation as a By-product

Early Regional Inflammation: The Seeds of Lung Injury

Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity

Inflammation Increases Neuronal Sensitivity to General Anesthetics

Resolution of Inflammation by Resolvin D1 Is Essential for Peroxisome Proliferator–activated Receptor-γ–mediated Analgesia during Postincisional Pain Development in Type 2 Diabetes

Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study

Effect of Therapeutic Hypercapnia on Inflammatory Responses to One-lung Ventilation in Lobectomy Patients

Effects of Ultraprotective Ventilation, Extracorporeal Carbon Dioxide Removal, and Spontaneous Breathing on Lung Morphofunction and Inflammation in Experimental Severe Acute Respiratory Distress Syndrome

Blocking the Mineralocorticoid Receptor Improves Effectiveness of Steroid Treatment for Low Back Pain in Rats

Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing

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