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Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

John J. Savarese, M.D., Hiroshi Sunaga, M.D., Jeff D. McGilvra, Ph.D., Matthew R. Belmont, M.D., Matthew T. Murrell, M.D., Ph.D., Erin Jeannotte, L.V.T., R.Lat.G., Farrell E. Cooke, B.S., William B. Wastila, Ph.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. November 2018: 129(5):970–988
DOI: https://doi.org/10.1097/ALN.0000000000002408
Published: November 2018
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Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011

John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Hiroshi Sunaga, M.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Peter M. Savard, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2010: 113(1):58–73
DOI: https://doi.org/10.1097/ALN.0b013e3181dc1b5b
Published: July 2010
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Gantacurium and CW002 Do Not Potentiate Muscarinic Receptor-mediated Airway Smooth Muscle Constriction in Guinea Pigs

Hiroshi Sunaga, M.D., Yi Zhang, M.D., John J. Savarese, M.D., Charles W. Emala, M.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):892–899
DOI: https://doi.org/10.1097/ALN.0b013e3181d32016
Published: April 2010
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