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Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Helen Hoyt, B.S., Ryan J. Fantasia, B.S., Kieran Bhave, B.A., Xiaoxuan Yang, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. November 2022: 137(5):568–585

https://doi.org/10.1097/ALN.0000000000004361

Published: November 2022

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Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., F.R.S.C.

Anesthesiology. July 2021: 135(1):18–30

https://doi.org/10.1097/ALN.0000000000003798

Published: July 2021

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Articles

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Beatrijs I. Valk, M.D., Douglas J. Eleveld, Ph.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.

Anesthesiology. January 2021: 134(1):35–51

https://doi.org/10.1097/ALN.0000000000003590

Published: January 2021

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Articles

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA A Receptor and In Vivo Zebrafish Studies

Megan McGrath, B.S., Helen Hoyt, B.A., Andrea Pence, B.S., Selwyn S. Jayakar, Ph.D., Xiaojuan Zhou, Ph.D., Stuart A. Forman, M.D., Ph.D., Jonathan B. Cohen, Ph.D., Keith W. Miller, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. September 2020: 133(3):583–594

https://doi.org/10.1097/ALN.0000000000003403

Published: September 2020

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Articles

Musings from an Unlikely Clinician–Scientist: 2018 American Society of Anesthesiologists Excellence in Research Award

Beverley A. Orser, M.D., Ph.D.

Anesthesiology. October 2019: 131(4):795–800

https://doi.org/10.1097/ALN.0000000000002881

Published: October 2019

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Articles

Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid

Beatrijs I. Valk, B.S., Megan McGrath, B.S., Dario Lehoux, Ph.D., Brad Zerler, Ph.D., John J. A. Marota, Ph.D, M.D., Douglas E. Raines, M.D.

Anesthesiology. August 2019: 131(2):287–304

https://doi.org/10.1097/ALN.0000000000002758

Published: August 2019

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Articles

GABA A Receptor Theory of Perioperative Neurocognitive Disorders

Beverley A. Orser, M.D., Ph.D., Dian-Shi Wang, M.D., Ph.D.

Anesthesiology. April 2019: 130(4):618–619

https://doi.org/10.1097/ALN.0000000000002562

Published: April 2019

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Articles

Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

Megan McGrath, B.S., Zhiyi Yu, Ph.D., Selwyn S. Jayakar, Ph.D., Celena Ma, B.S., Mansi Tolia, M.S., Xiaojuan Zhou, Ph.D., Keith W. Miller, D.Phil., Jonathan B. Cohen, Ph.D., Douglas E. Raines, M.D.

Anesthesiology. November 2018: 129(5):959–969

https://doi.org/10.1097/ALN.0000000000002356

Published: November 2018

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Articles

Gone Fishing…

Roderic G. Eckenhoff, M.D.

Anesthesiology. September 2018: 129(3):392–393

https://doi.org/10.1097/ALN.0000000000002328

Published: September 2018

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Articles

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Alexis M. Ziemba, B.A., Andrea Szabo, B.S., David W. Pierce, B.S., Marian Haburcak, Ph.D., Alex T. Stern, B.S., Anahita Nourmahnad, B.S., Elizabeth S. Halpin, B.A., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. February 2018: 128(2):338–351

https://doi.org/10.1097/ALN.0000000000001978

Published: February 2018

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Articles

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy

Celena Ma, B.S., Ervin Pejo, B.S., Megan McGrath, B.S., Selwyn S. Jayakar, Ph.D., Xiaojuan Zhou, Ph.D., Keith W. Miller, D.Phil., Jonathan B. Cohen, Ph.D., Douglas E. Raines, M.D.

Anesthesiology. November 2017: 127(5):824–837

https://doi.org/10.1097/ALN.0000000000001840

Published: November 2017

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Articles

Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons

Dian-Shi Wang, M.D., Ph.D., Antonello Penna, M.D., Ph.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. April 2017: 126(4):666–677

https://doi.org/10.1097/ALN.0000000000001483

Published: April 2017

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Articles

γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs

Ervin Pejo, B.S., Peter Santer, M.D., Lei Wang, Ph.D., Philip Dershwitz, B.S., S. Shaukat Husain, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. March 2016: 124(3):651–663

https://doi.org/10.1097/ALN.0000000000000992

Published: March 2016

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Articles

Inflammation Increases Neuronal Sensitivity to General Anesthetics

Sinziana Avramescu, M.D., Ph.D., Dian-Shi Wang, M.D., Ph.D., Irene Lecker, Ph.D., William T. H. To, M.Sc., Antonello Penna, M.D., Ph.D., Paul D. Whissell, Ph.D., Lia Mesbah-Oskui, M.Sc., Richard L. Horner, Ph.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. February 2016: 124(2):417–427

https://doi.org/10.1097/ALN.0000000000000943

Published: February 2016

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Articles

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Alex T. Stern, B.S., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. January 2016: 124(1):89–100

https://doi.org/10.1097/ALN.0000000000000934

Published: January 2016

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Articles

Analogues of Etomidate: Modifications around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Ervin Pejo, B.S., Peter Santer, M.D., Spencer Jeffrey, Hilary Gallin, B.S., S. Shaukat Husain, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. August 2014: 121(2):290–301

https://doi.org/10.1097/ALN.0000000000000268

Published: August 2014

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Articles

Tranexamic Acid Impairs γ-Aminobutyric Acid Receptor Type A–mediated Synaptic Transmission in the Murine Amygdala: A Potential Mechanism for Drug-induced Seizures?

Stephan Kratzer, M.D., Hedwig Irl, M.S., Corinna Mattusch, Ph.D., Martina Bürge, M.D., Jörg Kurz, M.D., Eberhard Kochs, M.D., Matthias Eder, Ph.D., Gerhard Rammes, Ph.D., Rainer Haseneder, M.D.

Anesthesiology. March 2014: 120(3):639–649

https://doi.org/10.1097/ALN.0000000000000103

Published: March 2014

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Articles

The Benzodiazepine Diazepam Potentiates Responses of α1β2γ2L γ-Aminobutyric Acid Type A Receptors Activated by either γ-Aminobutyric Acid or Allosteric Agonists

Ping Li, M.D., Ph.D., Megan M. Eaton, M.Sc., Joe Henry Steinbach, Ph.D., Gustav Akk, Ph.D.

Anesthesiology. June 2013: 118(6):1417–1425

https://doi.org/10.1097/ALN.0b013e318289bcd3

Published: June 2013

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Articles

Isoflurane Regulates Atypical Type-A γ-Aminobutyric Acid Receptors in Alveolar Type II Epithelial Cells

Yun-Yan Xiang, M.D., Ph.D., Xuanmao Chen, Ph.D., Jingxin Li, M.D., Ph.D., Shuanglian Wang, M.D., Ph.D., Gil Faclier, M.D., F.R.C.P.C., John F. MacDonald, Ph.D., James C. Hogg, M.D., Ph.D., F.R.C.P.C., Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., Wei-Yang Lu, M.D., Ph.D.

Anesthesiology. May 2013: 118(5):1065–1075

https://doi.org/10.1097/ALN.0b013e31828e180e

Published: May 2013

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Articles

Bidirectional Regulation of Intravenous General Anesthetic Actions by α3-containing γ-aminobutyric Acid A Receptors

Carolin J. Straub, Ph.D., Hew Mun Lau, B.Sc., Rosanna Parlato, Ph.D., Guenther Schuetz, M.D., Jean-Marc Fritschy, Ph.D., Uwe Rudolph, M.D.

Anesthesiology. March 2013: 118(3):562–576

https://doi.org/10.1097/ALN.0b013e3182800d76

Published: March 2013

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NARROW

Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA A Receptor and In Vivo Zebrafish Studies

Musings from an Unlikely Clinician–Scientist: 2018 American Society of Anesthesiologists Excellence in Research Award

Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid

GABA A Receptor Theory of Perioperative Neurocognitive Disorders

Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

Gone Fishing…

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy

Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons

γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs

Inflammation Increases Neuronal Sensitivity to General Anesthetics

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Analogues of Etomidate: Modifications around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Tranexamic Acid Impairs γ-Aminobutyric Acid Receptor Type A–mediated Synaptic Transmission in the Murine Amygdala: A Potential Mechanism for Drug-induced Seizures?

The Benzodiazepine Diazepam Potentiates Responses of α1β2γ2L γ-Aminobutyric Acid Type A Receptors Activated by either γ-Aminobutyric Acid or Allosteric Agonists

Isoflurane Regulates Atypical Type-A γ-Aminobutyric Acid Receptors in Alveolar Type II Epithelial Cells

Bidirectional Regulation of Intravenous General Anesthetic Actions by α3-containing γ-aminobutyric Acid A Receptors

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