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Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Helen Hoyt, B.S., Ryan J. Fantasia, B.S., Kieran Bhave, B.A., Xiaoxuan Yang, M.D., Ph.D., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. November 2022: 137(5):568–585

https://doi.org/10.1097/ALN.0000000000004361

Published: November 2022

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Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., F.R.S.C.

Anesthesiology. July 2021: 135(1):18–30

https://doi.org/10.1097/ALN.0000000000003798

Published: July 2021

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Articles

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA A Receptor and In Vivo Zebrafish Studies

Megan McGrath, B.S., Helen Hoyt, B.A., Andrea Pence, B.S., Selwyn S. Jayakar, Ph.D., Xiaojuan Zhou, Ph.D., Stuart A. Forman, M.D., Ph.D., Jonathan B. Cohen, Ph.D., Keith W. Miller, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. September 2020: 133(3):583–594

https://doi.org/10.1097/ALN.0000000000003403

Published: September 2020

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Articles

Reduced Sensitivity to Anesthetic Agents upon Lesioning the Mesopontine Tegmental Anesthesia Area in Rats Depends on Anesthetic Type

Anne Minert, Ph.D., Mark Baron, M.Sc., Marshall Devor, Ph.D.

Anesthesiology. March 2020: 132(3):535–550

https://doi.org/10.1097/ALN.0000000000003087

Published: March 2020

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Articles

Electrocardiographic Effects of Propofol versus Etomidate in Patients with Brugada Syndrome

Panagiotis Flamée, M.D., Varnavas Varnavas, M.D., Ph.D., Wendy Dewals, M.D., Hugo Carvalho, M.D., Wilfried Cools, Ph.D., Jigme Tshering Bhutia, M.D., Stefan Beckers, M.D., Vincent Umbrain, M.D., Ph.D., Christian Verborgh, M.D., Ph.D., Patrice Forget, M.D., Ph.D., Gian-Battista Chierchia, M.D., Ph.D., Pedro Brugada, M.D., Ph.D., Jan Poelaert, M.D., Ph.D., Carlo de Asmundis, M.D., Ph.D.

Anesthesiology. March 2020: 132(3):440–451

https://doi.org/10.1097/ALN.0000000000003030

Published: March 2020

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Articles

Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid

Beatrijs I. Valk, B.S., Megan McGrath, B.S., Dario Lehoux, Ph.D., Brad Zerler, Ph.D., John J. A. Marota, Ph.D, M.D., Douglas E. Raines, M.D.

Anesthesiology. August 2019: 131(2):287–304

https://doi.org/10.1097/ALN.0000000000002758

Published: August 2019

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Articles

Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

Megan McGrath, B.S., Zhiyi Yu, Ph.D., Selwyn S. Jayakar, Ph.D., Celena Ma, B.S., Mansi Tolia, M.S., Xiaojuan Zhou, Ph.D., Keith W. Miller, D.Phil., Jonathan B. Cohen, Ph.D., Douglas E. Raines, M.D.

Anesthesiology. November 2018: 129(5):959–969

https://doi.org/10.1097/ALN.0000000000002356

Published: November 2018

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Articles

Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia

Dian-Shi Wang, M.D., Ph.D., Kirusanthy Kaneshwaran, M.Sc., Gang Lei, M.Sc., M.D., Fariya Mostafa, M.Sc., Junhui Wang, M.D., Ph.D., Irene Lecker, Ph.D., Sinziana Avramescu, M.D., Ph.D., Yu-Feng Xie, M.D., Ph.D., Nathan K. Chan, B.Sc., Alejandro Fernandez-Escobar, M.D., Junsung Woo, Ph.D., Darren Chan, B.Sc., Amy J. Ramsey, Ph.D., Jeremy M. Sivak, Ph.D., C. Justin Lee, Ph.D., Robert P. Bonin, Ph.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. September 2018: 129(3):477–489

https://doi.org/10.1097/ALN.0000000000002311

Published: September 2018

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Articles

Gone Fishing…

Roderic G. Eckenhoff, M.D.

Anesthesiology. September 2018: 129(3):392–393

https://doi.org/10.1097/ALN.0000000000002328

Published: September 2018

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Articles

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Alexis M. Ziemba, B.A., Andrea Szabo, B.S., David W. Pierce, B.S., Marian Haburcak, Ph.D., Alex T. Stern, B.S., Anahita Nourmahnad, B.S., Elizabeth S. Halpin, B.A., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. February 2018: 128(2):338–351

https://doi.org/10.1097/ALN.0000000000001978

Published: February 2018

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Articles

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy

Celena Ma, B.S., Ervin Pejo, B.S., Megan McGrath, B.S., Selwyn S. Jayakar, Ph.D., Xiaojuan Zhou, Ph.D., Keith W. Miller, D.Phil., Jonathan B. Cohen, Ph.D., Douglas E. Raines, M.D.

Anesthesiology. November 2017: 127(5):824–837

https://doi.org/10.1097/ALN.0000000000001840

Published: November 2017

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Articles

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics–Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose

Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Beatrijs I. Valk, B.Sc., Douglas J. Eleveld, Ph.D., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Thomas Chou, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc.

Anesthesiology. July 2017: 127(1):20–35

https://doi.org/10.1097/ALN.0000000000001662

Published: July 2017

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Articles

Sedative-hypnotic Binding to 11β-hydroxylase

Ervin Pejo, B.S., Xiaojuan Zhou, Ph.D., S. Shaukat Husain, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. November 2016: 125(5):943–951

https://doi.org/10.1097/ALN.0000000000001304

Published: November 2016

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Articles

Enhanced Thalamic Spillover Inhibition during Non–rapid-eye-movement Sleep Triggers an Electrocortical Signature of Anesthetic Hypnosis

Lia Mesbah-Oskui, M.Sc., Richard L. Horner, Ph.D.

Anesthesiology. November 2016: 125(5):964–978

https://doi.org/10.1097/ALN.0000000000001307

Published: November 2016

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Articles

γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs

Ervin Pejo, B.S., Peter Santer, M.D., Lei Wang, Ph.D., Philip Dershwitz, B.S., S. Shaukat Husain, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. March 2016: 124(3):651–663

https://doi.org/10.1097/ALN.0000000000000992

Published: March 2016

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Articles

Inflammation Increases Neuronal Sensitivity to General Anesthetics

Sinziana Avramescu, M.D., Ph.D., Dian-Shi Wang, M.D., Ph.D., Irene Lecker, Ph.D., William T. H. To, M.Sc., Antonello Penna, M.D., Ph.D., Paul D. Whissell, Ph.D., Lia Mesbah-Oskui, M.Sc., Richard L. Horner, Ph.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. February 2016: 124(2):417–427

https://doi.org/10.1097/ALN.0000000000000943

Published: February 2016

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Articles

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Alex T. Stern, B.S., Stuart A. Forman, M.D., Ph.D.

Anesthesiology. January 2016: 124(1):89–100

https://doi.org/10.1097/ALN.0000000000000934

Published: January 2016

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Articles

Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis

Peter Santer, M.D., Ervin Pejo, B.S., Yan Feng, M.D., Ph.D., Wei Chao, M.D., Ph.D., Douglas E. Raines, M.D.

Anesthesiology. August 2015: 123(2):368–376

https://doi.org/10.1097/ALN.0000000000000721

Published: August 2015

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Articles

Analogues of Etomidate: Modifications around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Ervin Pejo, B.S., Peter Santer, M.D., Spencer Jeffrey, Hilary Gallin, B.S., S. Shaukat Husain, D.Phil., Douglas E. Raines, M.D.

Anesthesiology. August 2014: 121(2):290–301

https://doi.org/10.1097/ALN.0000000000000268

Published: August 2014

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Articles

Etomidate Use and Postoperative Outcomes among Cardiac Surgery Patients

Chad E. Wagner, M.D., Julian S. Bick, M.D., Daniel Johnson, Pharm.D., Rashid Ahmad, M.D., Xue Han, M.P.H., Jesse M. Ehrenfeld, M.D., Jonathan S. Schildcrout, Ph.D., Mias Pretorius, M.B.Ch.B., M.S.C.I.

Anesthesiology. March 2014: 120(3):579–589

https://doi.org/10.1097/ALN.0000000000000087

Published: March 2014

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NARROW

Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors

Anesthesiology: Resetting Our Sights on Long-term Outcomes: The 2020 John W. Severinghaus Lecture on Translational Science

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA A Receptor and In Vivo Zebrafish Studies

Reduced Sensitivity to Anesthetic Agents upon Lesioning the Mesopontine Tegmental Anesthesia Area in Rats Depends on Anesthetic Type

Electrocardiographic Effects of Propofol versus Etomidate in Patients with Brugada Syndrome

Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid

Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect

Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia

Gone Fishing…

Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics–Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose

Sedative-hypnotic Binding to 11β-hydroxylase

Enhanced Thalamic Spillover Inhibition during Non–rapid-eye-movement Sleep Triggers an Electrocortical Signature of Anesthetic Hypnosis

γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs

Inflammation Increases Neuronal Sensitivity to General Anesthetics

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis

Analogues of Etomidate: Modifications around Etomidate’s Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology

Etomidate Use and Postoperative Outcomes among Cardiac Surgery Patients

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