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Allometric Scaling in Pharmacokinetic Studies in Anesthesiology

Douglas J. Eleveld, Ph.D., Jeroen V. Koomen, Ph.D., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Hong Su, M.Sc., Laura N. Hannivoort, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.

Anesthesiology. April 2022: 136(4):609–617

DOI: https://doi.org/10.1097/ALN.0000000000004115

Published: April 2022

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Articles

Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say

Thomas K. Henthorn, M.D., Tom C. Krejcie, M.D., Michael J. Avram, Ph.D.

Anesthesiology. February 2022: 136(2):258–260

DOI: https://doi.org/10.1097/ALN.0000000000004087

Published: February 2022

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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Ricardo Alvarez-Jimenez, M.D., Ph.D., Maud A. S. Weerink, M.D., Laura N. Hannivoort, M.D., Ph.D., Hong Su, Pharm.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Stephan A. Loer, M.D., Ph.D., Pieter J. Colin, Pharm.D., Ph.D.

Anesthesiology. February 2022: 136(2):279–292

DOI: https://doi.org/10.1097/ALN.0000000000004049

Published: February 2022

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Articles

Can We Finally Take the “V E ” Out of THRIVE?

Allan F. Simpao, M.D., M.B.I., Martin J. London, M.D.

Anesthesiology. January 2022: 136(1):1–3

DOI: https://doi.org/10.1097/ALN.0000000000004051

Published: January 2022

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Articles

Effect of Global Ventilation to Perfusion Ratio, for Normal Lungs, on Desflurane and Sevoflurane Elimination Kinetics

James E. Baumgardner, M.D., Ph.D., M.D. (hc), Moritz Kretzschmar, M.D., Ph.D., D.E.S.A., Alf Kozian, M.D., Ph.D., Thomas Hachenberg, M.D., Ph.D., Thomas Schilling, M.D., Ph.D., D.E.A.A., Anders Larsson, M.D., Ph.D., D.E.A.A., Göran Hedenstierna, M.D., Ph.D.

Anesthesiology. December 2021: 135(6):1042–1054

DOI: https://doi.org/10.1097/ALN.0000000000004008

Published: December 2021

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Articles

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Beatrijs I. Valk, M.D., Douglas J. Eleveld, Ph.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.

Anesthesiology. January 2021: 134(1):35–51

DOI: https://doi.org/10.1097/ALN.0000000000003590

Published: January 2021

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Articles

Ketamine Pharmacokinetics: A Systematic Review of the Literature, Meta-analysis, and Population Analysis

Jasper Kamp, Pharm.D., Erik Olofsen, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D., for the Ketamine Pharmacokinetic Study Group

Anesthesiology. December 2020: 133(6):1192–1213

DOI: https://doi.org/10.1097/ALN.0000000000003577

Published: December 2020

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Articles

Transient Receptor Potential Melastatin 2 Regulates Phagosome Maturation and Is Required for Bacterial Clearance in Escherichia coli Sepsis

ZhanQin Zhang, M.Sc., Ping Cui, M.Sc., Kai Zhang, M.D., QiXing Chen, Ph.D., XiangMing Fang, M.D.

Anesthesiology. January 2017: 126(1):128–139

DOI: https://doi.org/10.1097/ALN.0000000000001430

Published: January 2017

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Articles

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

Evan D. Kharasch, M.D., Ph.D., Karen J. Regina, M.S., Jane Blood, R.N., Christina Friedel, B.S.

Anesthesiology. November 2015: 123(5):1142–1153

DOI: https://doi.org/10.1097/ALN.0000000000000867

Published: November 2015

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Articles

Impaired Autophagosome Clearance Contributes to Local Anesthetic Bupivacaine-induced Myotoxicity in Mouse Myoblasts

Rongrong Li, M.D., He Ma, M.D., Xiaojin Zhang, B.S., Chuanfu Li, M.D., Jingwei Xiong, M.D., Ting Lu, M.D., Yu Mao, B.S., Juncheng Dai, Ph.D., Li Liu, M.D., Ph.D., Zhengnian Ding, M.D., Ph.D.

Anesthesiology. March 2015: 122(3):595–605

DOI: https://doi.org/10.1097/ALN.0000000000000568

Published: March 2015

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Articles

Transient Receptor Potential Melastatin 2 Protects Mice against Polymicrobial Sepsis by Enhancing Bacterial Clearance

XiaoWei Qian, M.Sc., Tomohiro Numata, Ph.D., Kai Zhang, M.Sc., CaiXia Li, M.Sc., JinChao Hou, M.Sc., Yasuo Mori, Ph.D., XiangMing Fang, M.D.

Anesthesiology. August 2014: 121(2):336–351

DOI: https://doi.org/10.1097/ALN.0000000000000275

Published: August 2014

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Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study

Alana M. Flexman, M.D., Harvey Wong, Ph.D., K. Wayne Riggs, Ph.D., Tina Shih, M.D., Paul A. Garcia, M.D., Susana Vacas, M.D., Pekka O. Talke, M.D.

Anesthesiology. May 2014: 120(5):1118–1125

DOI: https://doi.org/10.1097/ALN.0000000000000141

Published: May 2014

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Articles

Lactate Clearance in the Acutely Traumatized Patient

Alan E. Jones, M.D.

Anesthesiology. December 2012: 117(6):1162–1164

DOI: https://doi.org/10.1097/ALN.0b013e31827334c2

Published: December 2012

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Articles

Prognostic Significance of Blood Lactate and Lactate Clearance in Trauma Patients

Marie-Alix Régnier, M.D., Mathieu Raux, M.D., Ph.D., Yannick Le Manach, M.D., Yves Asencio, M.D. M.Sc, Johann Gaillard, M.D., Catherine Devilliers, Pharm. D., Olivier Langeron, M.D., Ph.D., Bruno Riou, M.D., Ph.D.

Anesthesiology. December 2012: 117(6):1276–1288

DOI: https://doi.org/10.1097/ALN.0b013e318273349d

Published: December 2012

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Articles

Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)

Evan D. Kharasch, M.D., Ph.D., Pamela Sheffels Bedynek, B.S., Christine Hoffer, B.A., Alysa Walker, B.S., Dale Whittington, B.S.

Anesthesiology. February 2012: 116(2):432–447

DOI: https://doi.org/10.1097/ALN.0b013e3182423478

Published: February 2012

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Articles

Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

Virginia Guptill, Ph.D., Xizhong Cui, M.D., Ph.D., Alfia Khaibullina, Ph.D., Jason M. Keller, B.S., Nicholas Spornick, B.S., Andrew Mannes, M.D., Michael Iadarola, Ph.D., Zenaide M. N. Quezado, M.D.

Anesthesiology. May 2011: 114(5):1190–1199

DOI: https://doi.org/10.1097/ALN.0b013e318212515b

Published: May 2011

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Articles

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport: Insights from Methadone Interactions with Ritonavir/Indinavir

Evan D. Kharasch, M.D., Ph.D., Christine Hoffer, B.A., Dale Whittington, B.S., Alysa Walker, B.S., Pamela Sheffels Bedynek, B.S.

Anesthesiology. March 2009: 110(3):660–672

DOI: https://doi.org/10.1097/ALN.0b013e3181986a9a

Published: March 2009

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Articles

Response to Recruitment Maneuver Influences Net Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome

Jean-Michel Constantin, M.D., Sophie Cayot-Constantin, M.D., Laurence Roszyk, M.D., Emmanuel Futier, M.D., Vincent Sapin, M.D., Ph.D., Bernard Dastugue, M.D., Ph.D., Jean-Etienne Bazin, M.D., Ph.D., Jean-Jacques Rouby, M.D., Ph.D.

Anesthesiology. May 2007: 106(5):944–951

DOI: https://doi.org/10.1097/01.anes.0000265153.17062.64

Published: May 2007

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Articles

Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil

Andra E. Ibrahim, M.D., Jennifer Feldman, B.A., Aziz Karim, Ph.D., Evan D. Kharasch, M.D., Ph.D.

Anesthesiology. April 2003: 98(4):853–861

DOI: https://doi.org/10.1097/00000542-200304000-00011

Published: April 2003

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Articles

Acetaminophen Developmental Pharmacokinetics in Premature Neonates and Infants: A Pooled Population Analysis

Brian J. Anderson, F.A.N.Z.C.A., Richard A. van Lingen, M.D., Ph.D., Tom G. Hansen, M.D., Yuan-Chi Lin, M.D., M.P.H., Nicholas H. G. Holford, F.R.A.C.P.

Anesthesiology. June 2002: 96(6):1336–1345

DOI: https://doi.org/10.1097/00000542-200206000-00012

Published: June 2002

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NARROW

Allometric Scaling in Pharmacokinetic Studies in Anesthesiology

Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say

Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Can We Finally Take the “V E ” Out of THRIVE?

Effect of Global Ventilation to Perfusion Ratio, for Normal Lungs, on Desflurane and Sevoflurane Elimination Kinetics

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Ketamine Pharmacokinetics: A Systematic Review of the Literature, Meta-analysis, and Population Analysis

Transient Receptor Potential Melastatin 2 Regulates Phagosome Maturation and Is Required for Bacterial Clearance in Escherichia coli Sepsis

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

Impaired Autophagosome Clearance Contributes to Local Anesthetic Bupivacaine-induced Myotoxicity in Mouse Myoblasts

Transient Receptor Potential Melastatin 2 Protects Mice against Polymicrobial Sepsis by Enhancing Bacterial Clearance

Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study

Lactate Clearance in the Acutely Traumatized Patient

Prognostic Significance of Blood Lactate and Lactate Clearance in Trauma Patients

Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)

Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport: Insights from Methadone Interactions with Ritonavir/Indinavir

Response to Recruitment Maneuver Influences Net Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome

Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil

Acetaminophen Developmental Pharmacokinetics in Premature Neonates and Infants: A Pooled Population Analysis

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