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Articles

Deep Isoflurane Anesthesia Is Associated with Alterations in Ion Homeostasis and Specific Na + /K + -ATPase Impairment in the Rat Brain

This article has a Video Abstract
Clemens Reiffurth, Ph.D., Nikolaus Berndt, Ph.D., Adrian Gonzalez Lopez, Ph.D., Karl Schoknecht, M.D., Ph.D., Richard Kovács, Ph.D., Mathilde Maechler, Mirja grote Lambers, Jens P. Dreier, M.D., Alon Friedman, M.D., Ph.D., Claudia Spies, M.D., Agustin Liotta, M.D.
Publication: Anesthesiology
Anesthesiology. June 2023: 138(6):611–623
https://doi.org/10.1097/ALN.0000000000004553
Published: June 2023
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Allometric Scaling in Pharmacokinetic Studies in Anesthesiology

Douglas J. Eleveld, Ph.D., Jeroen V. Koomen, Ph.D., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Hong Su, M.Sc., Laura N. Hannivoort, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.
Publication: Anesthesiology
Anesthesiology. April 2022: 136(4):609–617
https://doi.org/10.1097/ALN.0000000000004115
Published: April 2022
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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

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Ricardo Alvarez-Jimenez, M.D., Ph.D., Maud A. S. Weerink, M.D., Laura N. Hannivoort, M.D., Ph.D., Hong Su, Pharm.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Stephan A. Loer, M.D., Ph.D., Pieter J. Colin, Pharm.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2022: 136(2):279–292
https://doi.org/10.1097/ALN.0000000000004049
Published: February 2022
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Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say

Thomas K. Henthorn, M.D., Tom C. Krejcie, M.D., Michael J. Avram, Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2022: 136(2):258–260
https://doi.org/10.1097/ALN.0000000000004087
Published: February 2022
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Articles

Can We Finally Take the “V E ” Out of THRIVE?

This article has an Audio Podcast
Allan F. Simpao, M.D., M.B.I., Martin J. London, M.D.
Publication: Anesthesiology
Anesthesiology. January 2022: 136(1):1–3
https://doi.org/10.1097/ALN.0000000000004051
Published: January 2022
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Effect of Global Ventilation to Perfusion Ratio, for Normal Lungs, on Desflurane and Sevoflurane Elimination Kinetics

This article has a Visual Abstract This article has a Video Abstract
James E. Baumgardner, M.D., Ph.D., M.D. (hc), Moritz Kretzschmar, M.D., Ph.D., D.E.S.A., Alf Kozian, M.D., Ph.D., Thomas Hachenberg, M.D., Ph.D., Thomas Schilling, M.D., Ph.D., D.E.A.A., Anders Larsson, M.D., Ph.D., D.E.A.A., Göran Hedenstierna, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2021: 135(6):1042–1054
https://doi.org/10.1097/ALN.0000000000004008
Published: December 2021
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Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Beatrijs I. Valk, M.D., Douglas J. Eleveld, Ph.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.
Publication: Anesthesiology
Anesthesiology. January 2021: 134(1):35–51
https://doi.org/10.1097/ALN.0000000000003590
Published: January 2021
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Ketamine Pharmacokinetics: A Systematic Review of the Literature, Meta-analysis, and Population Analysis

Jasper Kamp, Pharm.D., Erik Olofsen, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D., for the Ketamine Pharmacokinetic Study Group
Publication: Anesthesiology
Anesthesiology. December 2020: 133(6):1192–1213
https://doi.org/10.1097/ALN.0000000000003577
Published: December 2020
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Transient Receptor Potential Melastatin 2 Regulates Phagosome Maturation and Is Required for Bacterial Clearance in Escherichia coli Sepsis

ZhanQin Zhang, M.Sc., Ping Cui, M.Sc., Kai Zhang, M.D., QiXing Chen, Ph.D., XiangMing Fang, M.D.
Publication: Anesthesiology
Anesthesiology. January 2017: 126(1):128–139
https://doi.org/10.1097/ALN.0000000000001430
Published: January 2017
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Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

Evan D. Kharasch, M.D., Ph.D., Karen J. Regina, M.S., Jane Blood, R.N., Christina Friedel, B.S.
Publication: Anesthesiology
Anesthesiology. November 2015: 123(5):1142–1153
https://doi.org/10.1097/ALN.0000000000000867
Published: November 2015
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Impaired Autophagosome Clearance Contributes to Local Anesthetic Bupivacaine-induced Myotoxicity in Mouse Myoblasts

Rongrong Li, M.D., He Ma, M.D., Xiaojin Zhang, B.S., Chuanfu Li, M.D., Jingwei Xiong, M.D., Ting Lu, M.D., Yu Mao, B.S., Juncheng Dai, Ph.D., Li Liu, M.D., Ph.D., Zhengnian Ding, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. March 2015: 122(3):595–605
https://doi.org/10.1097/ALN.0000000000000568
Published: March 2015
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Transient Receptor Potential Melastatin 2 Protects Mice against Polymicrobial Sepsis by Enhancing Bacterial Clearance

XiaoWei Qian, M.Sc., Tomohiro Numata, Ph.D., Kai Zhang, M.Sc., CaiXia Li, M.Sc., JinChao Hou, M.Sc., Yasuo Mori, Ph.D., XiangMing Fang, M.D.
Publication: Anesthesiology
Anesthesiology. August 2014: 121(2):336–351
https://doi.org/10.1097/ALN.0000000000000275
Published: August 2014
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Enzyme-inducing Anticonvulsants Increase Plasma Clearance of Dexmedetomidine: A Pharmacokinetic and Pharmacodynamic Study

Alana M. Flexman, M.D., Harvey Wong, Ph.D., K. Wayne Riggs, Ph.D., Tina Shih, M.D., Paul A. Garcia, M.D., Susana Vacas, M.D., Pekka O. Talke, M.D.
Publication: Anesthesiology
Anesthesiology. May 2014: 120(5):1118–1125
https://doi.org/10.1097/ALN.0000000000000141
Published: May 2014
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Lactate Clearance in the Acutely Traumatized Patient

Alan E. Jones, M.D.
Publication: Anesthesiology
Anesthesiology. December 2012: 117(6):1162–1164
https://doi.org/10.1097/ALN.0b013e31827334c2
Published: December 2012
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Prognostic Significance of Blood Lactate and Lactate Clearance in Trauma Patients

Marie-Alix Régnier, M.D., Mathieu Raux, M.D., Ph.D., Yannick Le Manach, M.D., Yves Asencio, M.D. M.Sc, Johann Gaillard, M.D., Catherine Devilliers, Pharm. D., Olivier Langeron, M.D., Ph.D., Bruno Riou, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2012: 117(6):1276–1288
https://doi.org/10.1097/ALN.0b013e318273349d
Published: December 2012
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Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)

Evan D. Kharasch, M.D., Ph.D., Pamela Sheffels Bedynek, B.S., Christine Hoffer, B.A., Alysa Walker, B.S., Dale Whittington, B.S.
Publication: Anesthesiology
Anesthesiology. February 2012: 116(2):432–447
https://doi.org/10.1097/ALN.0b013e3182423478
Published: February 2012
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Disruption of the Transient Receptor Potential Vanilloid 1 Can Affect Survival, Bacterial Clearance, and Cytokine Gene Expression during Murine Sepsis

Virginia Guptill, Ph.D., Xizhong Cui, M.D., Ph.D., Alfia Khaibullina, Ph.D., Jason M. Keller, B.S., Nicholas Spornick, B.S., Andrew Mannes, M.D., Michael Iadarola, Ph.D., Zenaide M. N. Quezado, M.D.
Publication: Anesthesiology
Anesthesiology. May 2011: 114(5):1190–1199
https://doi.org/10.1097/ALN.0b013e318212515b
Published: May 2011
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Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport: Insights from Methadone Interactions with Ritonavir/Indinavir

Evan D. Kharasch, M.D., Ph.D., Christine Hoffer, B.A., Dale Whittington, B.S., Alysa Walker, B.S., Pamela Sheffels Bedynek, B.S.
Publication: Anesthesiology
Anesthesiology. March 2009: 110(3):660–672
https://doi.org/10.1097/ALN.0b013e3181986a9a
Published: March 2009
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Response to Recruitment Maneuver Influences Net Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome

Jean-Michel Constantin, M.D., Sophie Cayot-Constantin, M.D., Laurence Roszyk, M.D., Emmanuel Futier, M.D., Vincent Sapin, M.D., Ph.D., Bernard Dastugue, M.D., Ph.D., Jean-Etienne Bazin, M.D., Ph.D., Jean-Jacques Rouby, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. May 2007: 106(5):944–951
https://doi.org/10.1097/01.anes.0000265153.17062.64
Published: May 2007
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Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil

Andra E. Ibrahim, M.D., Jennifer Feldman, B.A., Aziz Karim, Ph.D., Evan D. Kharasch, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2003: 98(4):853–861
https://doi.org/10.1097/00000542-200304000-00011
Published: April 2003
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