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Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial

Hyun-Jung Shin, M.D., Ph.D., Sun Woo Nam, M.D., Heeyeon Kim, M.D., Subin Yim, M.D., Sung-Hee Han, M.D., Ph.D., Jung-Won Hwang, M.D., Ph.D., Sang-Hwan Do, M.D., Ph.D., Hyo-Seok Na, M.D., Ph.D.

Anesthesiology. February 2023: 138(2):164–171

DOI: https://doi.org/10.1097/ALN.0000000000004438

Published: February 2023

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Articles

Post–cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest

Takamitsu Ikeda, M.D., Ph.D., Edilberto Amorim, M.D., Yusuke Miyazaki, M.D., Ph.D., Risako Kato, Ph.D., Eizo Marutani, M.D., Michael G. Silverman, M.D., M.P.H., Rajeev Malhotra, M.D., M.S., Ken Solt, M.D., Fumito Ichinose, M.D., Ph.D.

Anesthesiology. December 2022: 137(6):716–732

DOI: https://doi.org/10.1097/ALN.0000000000004390

Published: December 2022

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Articles

No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone, and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty

Felipe Muñoz-Leyva, M.D., James M. Jack, M.B.B.S., Anuj Bhatia, M.D., F.R.C.P.C., Ki Jinn Chin, M.B.B.S. (Hon), M.Med., F.A.N.Z.C.A., F.R.C.P.C., Rajiv Gandhi, M.D., M.S., F.R.C.S.C., Anahi Perlas, M.D., F.R.C.P.C., Rongyu Jin, M.D., Vincent Chan, M.D., F.R.C.P.C.

Anesthesiology. October 2022: 137(4):459–470

DOI: https://doi.org/10.1097/ALN.0000000000004326

Published: October 2022

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Articles

Population Pharmacokinetics of Intranasal Dexmedetomidine in Infants and Young Children

Bi L. Li, M.D., Yan P. Guan, M.D., Vivian M. Yuen, M.D., Wei Wei, M.D., Min Huang, Ph.D., Ma Z. Zhang, M.D., Ai W. Li, Ph.D., Joseph F. Standing, Ph.D., Guo P. Zhong, Ph.D., Xing R. Song, M.D.

Anesthesiology. August 2022: 137(2):163–175

DOI: https://doi.org/10.1097/ALN.0000000000004258

Published: August 2022

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Articles

Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Ricardo Alvarez-Jimenez, M.D., Ph.D., Maud A. S. Weerink, M.D., Laura N. Hannivoort, M.D., Ph.D., Hong Su, Pharm.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Stephan A. Loer, M.D., Ph.D., Pieter J. Colin, Pharm.D., Ph.D.

Anesthesiology. February 2022: 136(2):279–292

DOI: https://doi.org/10.1097/ALN.0000000000004049

Published: February 2022

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Articles

Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say

Thomas K. Henthorn, M.D., Tom C. Krejcie, M.D., Michael J. Avram, Ph.D.

Anesthesiology. February 2022: 136(2):258–260

DOI: https://doi.org/10.1097/ALN.0000000000004087

Published: February 2022

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Articles

Anesthesia Mechanisms: A Patchwork Quilt rather than a Wet Blanket?

Logan Voss, Ph.D., Jamie W. Sleigh, M.D.

Anesthesiology. October 2021: 135(4):568–569

DOI: https://doi.org/10.1097/ALN.0000000000003879

Published: October 2021

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Articles

Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia

Eric D. Melonakos, Ph.D., Morgan J. Siegmann, B.S., Charles Rey, B.S., Christopher O’Brien, B.S., Ksenia K. Nikolaeva, M.S., Ken Solt, M.D., Christa J. Nehs, Ph.D.

Anesthesiology. October 2021: 135(4):633–648

DOI: https://doi.org/10.1097/ALN.0000000000003883

Published: October 2021

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Articles

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The Postoperative and Opioid-free Anesthesia (POFA) Randomized Clinical Trial

Anesthesiology. April 2021: 134(4):541–551

DOI: https://doi.org/10.1097/ALN.0000000000003725

Published: April 2021

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Articles

A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine

Shubham Chamadia, Ph.D., Juan C. Pedemonte, M.D., Lauren E. Hobbs, M.A., Hao Deng, M.D., M.P.H., Sarah Nguyen, B.S., Luis I. Cortinez, M.D., Oluwaseun Akeju, M.D., M.M.Sc

Anesthesiology. December 2020: 133(6):1223–1233

DOI: https://doi.org/10.1097/ALN.0000000000003568

Published: December 2020

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Articles

Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans

Shubham Chamadia, Ph.D., Lauren Hobbs, M.S., Sophia Marota, Reine Ibala, B.S., Eunice Hahm, B.S., Jacob Gitlin, B.S., Jennifer Mekonnen, B.S., Breanna Ethridge, B.A., Katia M. Colon, B.S., Kimberly S. Sheppard, R.N., Dara S. Manoach, Ph.D., Alan DiBiasio, B.S. Pharm., Sarah Nguyen, B.S., Juan C. Pedemonte, M.D., Oluwaseun Akeju, M.D., M.M.Sc.

Anesthesiology. December 2020: 133(6):1234–1243

DOI: https://doi.org/10.1097/ALN.0000000000003567

Published: December 2020

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Articles

Dexmedetomidine and Cognitive Dysfunction after Critical Illness: What Can (and Cannot) Be Extrapolated from Rodent Models

Cameron W. Paterson, M.D., Craig M. Coopersmith, M.D.

Anesthesiology. August 2020: 133(2):258–261

DOI: https://doi.org/10.1097/ALN.0000000000003391

Published: August 2020

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Articles

Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

Gaolin Qiu, M.M., Ying Wu, M.M., Zeyong Yang, M.D., Ph.D., Long Li, M.M., Xiaona Zhu, Ph.D., Yiqiao Wang, M.D., Ph.D., Wenzhi Sun, Ph.D., Hailong Dong, M.D., Ph.D., Yuanhai Li, M.D., Ph.D., Ji Hu, Ph.D.

Anesthesiology. August 2020: 133(2):377–392

DOI: https://doi.org/10.1097/ALN.0000000000003347

Published: August 2020

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Articles

Dexmedetomidine Exerts an Anti-inflammatory Effect via α 2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice

Rong Li, M.D., Ieng K. Lai, B.S., Jonathan Z. Pan, M.D., Ph.D., Pengbo Zhang, M.D., Ph.D., Mervyn Maze, M.B., Ch.B.

Anesthesiology. August 2020: 133(2):393–407

DOI: https://doi.org/10.1097/ALN.0000000000003390

Published: August 2020

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Articles

Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study

Åse Lodenius, M.D., Ph.D., D.E.S.A., Kathleen J. Maddison, Ph.D., Brad K. Lawther, M.D., Mika Scheinin, M.D., Ph.D., Lars I. Eriksson, M.D., Ph.D., F.R.C.A., Peter R. Eastwood, Ph.D., David R. Hillman, M.B.B.S., Malin Jonsson Fagerlund, M.D., Ph.D., D.E.S.A., Jennifer H. Walsh, M.Sc., Ph.D.

Anesthesiology. November 2019: 131(5):962–973

DOI: https://doi.org/10.1097/ALN.0000000000002883

Published: November 2019

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Articles

Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy

Maud A. S. Weerink, M.D., Clemens R. M. Barends, M.D., Ernesto R. R. Muskiet, M.D., Koen M. E. M. Reyntjens, M.D., Froukje H. Knotnerus, R.N., Martine Oostra, R.N., Jan F. P. van Bocxlaer, Pharm.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A., Pieter J. Colin, Pharm.D., Ph.D.

Anesthesiology. November 2019: 131(5):1004–1017

DOI: https://doi.org/10.1097/ALN.0000000000002882

Published: November 2019

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Articles

Safe Sedation Re-examined: Comparing the Respiratory Effects of Dexmedetomidine and Propofol

Jonathan P. Wanderer, James P. Rathmell

Anesthesiology. November 2019: 131(5):A19

DOI: https://doi.org/10.1097/ALN.0000000000003008

Published: November 2019

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Articles

Dexmedetomidine and the Upper Airway: Not as Simple as We Hoped

Denham S. Ward, M.D., Ph.D., Suzanne B. Karan, M.D.

Anesthesiology. November 2019: 131(5):953–954

DOI: https://doi.org/10.1097/ALN.0000000000002965

Published: November 2019

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Articles

Discharge Readiness after Propofol with or without Dexmedetomidine for Colonoscopy: A Randomized Controlled Trial

Leonard U. Edokpolo, M.D., Daniel J. Mastriano, M.D., Joanna Serafin, Ph.D., Jeremy C. Weedon, Ph.D., Maryam T. Siddiqui, M.D., Dennis P. Dimaculangan, M.D.

Anesthesiology. August 2019: 131(2):279–286

DOI: https://doi.org/10.1097/ALN.0000000000002809

Published: August 2019

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Articles

Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo

Chunyan Wang, M.D., Ph.D., Tanweer Datoo, M.Res., B.Sc., Hailin Zhao, Ph.D., Lingzhi Wu, M.Res., B.Sc., Akshay Date, M.B.B.S., Cui Jiang, M.Res., B.Sc., Robert D. Sanders, M.B.B.S., Ph.D., F.R.C.A., Guolin Wang, M.D., Ph.D., Charlotte Bevan, Ph.D., Daqing Ma, M.D., Ph.D., F.R.C.A.

Anesthesiology. November 2018: 129(5):1000–1014

DOI: https://doi.org/10.1097/ALN.0000000000002401

Published: November 2018

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NARROW

Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial

Post–cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest

No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone, and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty

Population Pharmacokinetics of Intranasal Dexmedetomidine in Infants and Young Children

Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics

Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say

Anesthesia Mechanisms: A Patchwork Quilt rather than a Wet Blanket?

Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The Postoperative and Opioid-free Anesthesia (POFA) Randomized Clinical Trial

A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine

Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans

Dexmedetomidine and Cognitive Dysfunction after Critical Illness: What Can (and Cannot) Be Extrapolated from Rodent Models

Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

Dexmedetomidine Exerts an Anti-inflammatory Effect via α 2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice

Upper Airway Collapsibility during Dexmedetomidine and Propofol Sedation in Healthy Volunteers: A Nonblinded Randomized Crossover Study

Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy

Safe Sedation Re-examined: Comparing the Respiratory Effects of Dexmedetomidine and Propofol

Dexmedetomidine and the Upper Airway: Not as Simple as We Hoped

Discharge Readiness after Propofol with or without Dexmedetomidine for Colonoscopy: A Randomized Controlled Trial

Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo

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