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Articles

Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

John J. Savarese, M.D., Hiroshi Sunaga, M.D., Jeff D. McGilvra, Ph.D., Matthew R. Belmont, M.D., Matthew T. Murrell, M.D., Ph.D., Erin Jeannotte, L.V.T., R.Lat.G., Farrell E. Cooke, B.S., William B. Wastila, Ph.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. November 2018: 129(5):970–988
https://doi.org/10.1097/ALN.0000000000002408
Published: November 2018
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Alphaxalone Binds in Inner Transmembrane β + –α − Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors

Alexis M. Ziemba, B.A., Andrea Szabo, B.S., David W. Pierce, B.S., Marian Haburcak, Ph.D., Alex T. Stern, B.S., Anahita Nourmahnad, B.S., Elizabeth S. Halpin, B.A., Stuart A. Forman, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. February 2018: 128(2):338–351
https://doi.org/10.1097/ALN.0000000000001978
Published: February 2018
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Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat

Hiroshi Sunaga, M.D., John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Paul M. Heerdt, M.D., Ph.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Peter M. Savard, M.D., Erin Jeannotte, L.V.T., R.Lat.G., Bryce J. Petty, B.A., Erica Allen, Ph.D., Gilbert W. Carnathan, Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2016: 125(4):732–743
https://doi.org/10.1097/ALN.0000000000001254
Published: October 2016
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A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Alex T. Stern, B.S., Stuart A. Forman, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. January 2016: 124(1):89–100
https://doi.org/10.1097/ALN.0000000000000934
Published: January 2016
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Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011

John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Hiroshi Sunaga, M.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Peter M. Savard, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2010: 113(1):58–73
https://doi.org/10.1097/ALN.0b013e3181dc1b5b
Published: July 2010
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Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs: Pharmacodynamics, Acute Cardiovascular Effects, and Preliminary Toxicology

Hiroshi Sunaga, M.D., Jaideep K. Malhotra, M.D., Edward Yoon, B.S., John J. Savarese, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):900–909
https://doi.org/10.1097/ALN.0b013e3181d31f8c
Published: April 2010
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Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs

Paul M. Heerdt, M.D., Ph.D., Jaideep K. Malhotra, M.D., Brian Y. Pan, B.S., Hiroshi Sunaga, M.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):910–916
https://doi.org/10.1097/ALN.0b013e3181d31f71
Published: April 2010
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Compound A Uptake and Metabolism to Mercapturic Acids and 3,3,3-Trifluoro-2-fluoromethoxypropanoic Acid during Low-flow Sevoflurane Anesthesia   : Biomarkers for Exposure, Risk Assessment, and Interspecies Comparison

Evan D. Kharasch, M.D., Ph.D., Carole Jubert, Ph.D.
Publication: Anesthesiology
Anesthesiology. November 1999: 91(5):1267
https://doi.org/10.1097/00000542-199911000-00017
Published: November 1999
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Immunochemical Evidence against the Involvement of Cysteine Conjugate β-lyase in Compound A Nephrotoxicity in Rats

Dolores B. Njoku, MD, Lance R. Pohl, PharmD, PhD, Edward A. Sokoloski, BS, Michael R. Marchick, Craig B. Borkowf, PhD, Jackie L. Martin, MD
Publication: Anesthesiology
Anesthesiology. February 1999: 90(2):458–469
https://doi.org/10.1097/00000542-199902000-00021
Published: February 1999
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Fate and Toxicity of 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A)-derived Mercapturates in Male, Fischer 344 Rats

Vinita Uttamsingh, BS, Iyer A. Ramswamy, PhD, Raymond B. Baggs, DVM, PhD, M. W. Anders, DVM, PhD
Publication: Anesthesiology
Anesthesiology. November 1998: 89(5):1174–1183
https://doi.org/10.1097/00000542-199811000-00018
Published: November 1998
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Role of the Renal Cysteine Conjugate β-Lyase Pathway in Inhaled Compound A Nephrotoxicity in Rats

Evan D. Kharasch, MD, PhD, Gary M. Hoffman, BA, David Thorning, MD, Douglas C. Hankins, MA, Cormac G. Kilty, PhD
Publication: Anesthesiology
Anesthesiology. June 1998: 88(6):1624–1633
https://doi.org/10.1097/00000542-199806000-00027
Published: June 1998
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Cysteine Conjugate β-Lyase-Dependent Metabolism of Compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in Human Subjects Anesthetized with Sevoflurane and in Rats Given Compound A

Ramaswamy A. Iyer, PhD, Edward J. Frink, MD, Thomas J. Ebert, MD, PhD, M. W. Anders, DM, PhD
Publication: Anesthesiology
Anesthesiology. March 1998: 88(3):611–618
https://doi.org/10.1097/00000542-199803000-00009
Published: March 1998
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