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Articles

Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics

Julia Plakhotnik, B.Sc., Libo Zhang, M.D., Ph.D., Marvin Estrada, R.V.T., John G. Coles, M.D., Per-Arne Lonnqvist, M.D., Ph.D., Jason T. Maynes, M.D., Ph.D.

Anesthesiology. December 2022: 137(6):687–703

https://doi.org/10.1097/ALN.0000000000004389

Published: December 2022

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Articles

Left Ventricular Hypertrophy Increases Susceptibility to Bupivacaine-induced Cardiotoxicity through Overexpression of Transient Receptor Potential Canonical Channels in Rats

Hideki Hino, M.D., Tadashi Matsuura, M.D., Ph.D., Miyuki Kuno, M.D., Ph.D., Kotaro Hori, M.D., Ph.D., Shogo Tsujikawa, M.D., Ph.D., Takashi Mori, M.D., Ph.D., Kiyonobu Nishikawa, M.D., Ph.D.

Anesthesiology. November 2020: 133(5):1077–1092

https://doi.org/10.1097/ALN.0000000000003554

Published: November 2020

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Articles

Free Fatty Acid Receptor G-protein–coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection

Soban Umar, M.D., Ph.D., Jingyuan Li, M.D., Ph.D., Kyle Hannabass, M.D., Mylene Vaillancourt, M.Sc., Christine M. Cunningham, B.S., Shayan Moazeni, B.S., Aman Mahajan, M.D., Ph.D., Mansoureh Eghbali, Ph.D.

Anesthesiology. July 2018: 129(1):154–162

https://doi.org/10.1097/ALN.0000000000002195

Published: July 2018

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Articles

Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

Michael R. Fettiplace, M.S., Katarzyna Kowal, B.S., Richard Ripper, C.V.T., Alexandria Young, B.S., Kinga Lis, B.S., Israel Rubinstein, M.D., Marcelo Bonini, Ph.D., Richard Minshall, Ph.D., Guy Weinberg, M.D.

Anesthesiology. February 2016: 124(2):428–442

https://doi.org/10.1097/ALN.0000000000000974

Published: February 2016

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Articles

Resuscitation with Lipid Emulsion: Dose-dependent Recovery from Cardiac Pharmacotoxicity Requires a Cardiotonic Effect

Michael R. Fettiplace, M.S., Belinda S. Akpa, Ph.D., Richard Ripper, C.V.T., Brian Zider, B.S., Jason Lang, B.S., Israel Rubinstein, M.D., Guy Weinberg, M.D.

Anesthesiology. April 2014: 120(4):915–925

https://doi.org/10.1097/ALN.0000000000000142

Published: April 2014

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Articles

Carnitine Deficiency Increases Susceptibility to Bupivacaine-induced Cardiotoxicity in Rats

Gail K. Wong, M.B.B.S., F.A.N.Z.C.A., Mark W. Crawford, M.B.B.S., F.R.C.P.C.

Anesthesiology. June 2011: 114(6):1417–1424

https://doi.org/10.1097/ALN.0b013e31821a8d46

Published: June 2011

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Articles

Transient Cardiovascular Toxicity with Unintentional Intravascular Injection of 3% 2-Chloroprocaine in a 2-month-old Infant

Franklyn P. Cladis, M.D., Ronald S. Litman, D.O.

Anesthesiology. January 2004: 100(1):181–183

https://doi.org/10.1097/00000542-200401000-00030

Published: January 2004

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Articles

Differences in Cardiotoxicity of Bupivacaine and Ropivacaine Are the Result of Physicochemical and Stereoselective Properties

Bernhard M. Graf, M.D., Ingo Abraham, M.D., Nicole Eberbach, M.D., Gudrun Kunst, M.D., David F. Stowe, M.D., Ph.D., Eike Martin, M.D.

Anesthesiology. June 2002: 96(6):1427–1434

https://doi.org/10.1097/00000542-200206000-00023

Published: June 2002

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Articles

Protamine-induced Cardiotoxicity Is Prevented by Anti-TNF-α Antibodies and Heparin

Dmitry Pevni, M.D., Inna Frolkis, M.D., Ph.D., Adrian Iaina, M.D., Yoram Wollman, Ph.D., Tamara Chernichovski, Ms.C., Izhak Shapira, M.D., Josef Paz, M.D., Amir Kramer, M.D., Ph.D., Chaim Loker, M.D., Rephael Mohr, M.D.

Anesthesiology. December 2001: 95(6):1389–1395

https://doi.org/10.1097/00000542-200112000-00018

Published: December 2001

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Articles

Keep the Blood Red … The Right Way

Evan D. Kharasch, MD, PhD

Anesthesiology. August 1997: 87(2):202–203

https://doi.org/10.1097/00000542-199708000-00005

Published: August 1997

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Articles

Bupivacaine-induced Cardiac Toxicity in Neonates: Successful Treatment with Intravenous Phenytoin

Lynne G. Maxwell, M.D., Lynn D. Martin, M.D., Myron Yaster, M.D.

Anesthesiology. March 1994: 80(3):682–685

https://doi.org/10.1097/00000542-199403000-00028

Published: March 1994

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Articles

Bupivacaine Inhibits Cyclic-3', 5'-Adenosine Monophosphate Production A Possible Contributing Factor to Cardiovascular Toxicity

John F. Butterworth, M.D., R. Charles Brownlow, M.D., Jian Pang Leith, B.S., Richard C. Prielipp, M.D., Lisa R. Cole, M.A.

Anesthesiology. July 1993: 79(1):88–95

https://doi.org/10.1097/00000542-199307000-00014

Published: July 1993

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Articles

Severe Hypoxia Enhances Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Lightly Anesthetized Pigs

J. E. Heavner, D.V.M., Ph.D., C. F. Dryden, B.A., V. Sanghani, B.S., G. Huemer, M.D., A. Bessire, B.S., J. M. Badgwell, M.D.

Anesthesiology. July 1992: 77(1):142–147

https://doi.org/10.1097/00000542-199207000-00020

Published: July 1992

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Articles

A563 OXYGEN DEPENDENCY OF DOXORUBICIN CARDIOTOXICITY IN PERFUSED RAT HEARTS

R. A. Mueller, M.D, L. S. Carter, B.S, P. E. Ganey, Ph.D., R. G. Thurman, Ph.D.

Anesthesiology. September 1990: 73(3A):NA

https://doi.org/10.1097/00000542-199009001-00561

Published: September 1990

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Articles

The Effect of Magnesium Sulfate Administration on Cerebral and Cardiac Toxicity of Bupivacaine in Dogs

Dale Solomon, M.D., Leon Bunegin, B.S., Maurice Albin, M.D., M.S.

Anesthesiology. February 1990: 72(2):341–346

https://doi.org/10.1097/00000542-199002000-00021

Published: February 1990

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Articles

Effect of Midazolam and Diazepam Premedication on Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Pigs

Christopher M. Bernards, M.D., Randall L. Carpenter, M.D., Stephen M. Rupp, M.D., David L. Brown, M.D., Brent V. Morse, D.V.M., Robert C. Morell, M.D., Gale E. Thompson, M.D.

Anesthesiology. February 1989: 70(2):318–323

https://doi.org/10.1097/00000542-198902000-00023

Published: February 1989

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Articles

The Influence of Serum Potassium on the Cerebral and Cardiac Toxicity of Bupivacaine and Lidocaine

Pamela Avery, M.D., David Redon, B.S., George Schaenzer, M.D., Ben Rusy, M.D.

Anesthesiology. August 1984: 61(2):134–138

https://doi.org/10.1097/00000542-198408000-00004

Published: August 1984

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Articles

Cardiotoxicity of Local Anesthetics—The Plot Thickens

Gertie F. Marx, M.D.

Anesthesiology. January 1984: 60(1):3–5

https://doi.org/10.1097/00000542-198401000-00002

Published: January 1984

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Articles

CARDIOTOXIC VASOPRESSORS

Anesthesiology. May 1959: 20(3):396

https://doi.org/10.1097/00000542-195905000-00055

Published: May 1959

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NARROW

Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics

Left Ventricular Hypertrophy Increases Susceptibility to Bupivacaine-induced Cardiotoxicity through Overexpression of Transient Receptor Potential Canonical Channels in Rats

Free Fatty Acid Receptor G-protein–coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection

Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion

Resuscitation with Lipid Emulsion: Dose-dependent Recovery from Cardiac Pharmacotoxicity Requires a Cardiotonic Effect

Carnitine Deficiency Increases Susceptibility to Bupivacaine-induced Cardiotoxicity in Rats

Transient Cardiovascular Toxicity with Unintentional Intravascular Injection of 3% 2-Chloroprocaine in a 2-month-old Infant

Differences in Cardiotoxicity of Bupivacaine and Ropivacaine Are the Result of Physicochemical and Stereoselective Properties

Protamine-induced Cardiotoxicity Is Prevented by Anti-TNF-α Antibodies and Heparin

Keep the Blood Red … The Right Way

Bupivacaine-induced Cardiac Toxicity in Neonates: Successful Treatment with Intravenous Phenytoin

Bupivacaine Inhibits Cyclic-3', 5'-Adenosine Monophosphate Production A Possible Contributing Factor to Cardiovascular Toxicity

Severe Hypoxia Enhances Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Lightly Anesthetized Pigs

A563 OXYGEN DEPENDENCY OF DOXORUBICIN CARDIOTOXICITY IN PERFUSED RAT HEARTS

The Effect of Magnesium Sulfate Administration on Cerebral and Cardiac Toxicity of Bupivacaine in Dogs

Effect of Midazolam and Diazepam Premedication on Central Nervous System and Cardiovascular Toxicity of Bupivacaine in Pigs

The Influence of Serum Potassium on the Cerebral and Cardiac Toxicity of Bupivacaine and Lidocaine

Cardiotoxicity of Local Anesthetics—The Plot Thickens

CARDIOTOXIC VASOPRESSORS

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