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Articles

Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling

Tony L. Yaksh, Ph.D., Kelly A. Eddinger, B.S., R.V.T., Shinichi Kokubu, M.D., Ph.D., Zhenping Wang, Ph.D., Anna DiNardo, M.D., Ph.D., Roshni Ramachandran, Ph.D., Yuelian Zhu, Ph.D., Yajun He, M.D., Fieke Weren, M.S., Daphne Quang, B.S., Shelle A. Malkmus, B.S., R.V.T., Katherine Lansu, Ph.D., Wesley K. Kroeze, Ph.D., Brian Eliceiri, Ph.D., Joanne J. Steinauer, B.S., Peter W. Schiller, Ph.D., Peter Gmeiner, Ph.D., Linda M. Page, Pharm.D., Keith R. Hildebrand, D.V.M.

Anesthesiology. July 2019: 131(1):132–147

https://doi.org/10.1097/ALN.0000000000002730

Published: July 2019

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Articles

Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation

Kelly A. Eddinger, B.S., R.V.T., Eric S. Rondon, D.V.M., Veronica I. Shubayev, M.D., Marjorie R. Grafe, M.D., Ph.D., Miriam Scadeng, M.D., Keith R. Hildebrand, D.V.M., Ph.D., Linda M. Page, Pharm.D., Shelle A. Malkmus, B.S., R.V.T., Joanne J. Steinauer, B.S., Tony L. Yaksh, Ph.D.

Anesthesiology. August 2016: 125(2):378–394

https://doi.org/10.1097/ALN.0000000000001166

Published: August 2016

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Articles

Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs

Tony L. Yaksh, Ph.D., Shotaro Hobo, M.D., Christopher Peters, Ph.D., Kent G. Osborn, D.V.M., Ph.D., Philip J. Richter, Jr, D.V.M., Ph.D., D.A.C.L.A.M., Steven S. Rossi, Ph.D., Marjorie R. Grafe, M.D., Ph.D., James C. Eisenach, M.D.

Anesthesiology. April 2014: 120(4):951–961

https://doi.org/10.1097/ALN.0000000000000148

Published: April 2014

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Articles

Intrathecal Substance P-Saporin in the Dog: Distribution, Safety, and Spinal Neurokinin-1 Receptor Ablation

Ashley J. Wiese, D.V.M., Michael Rathbun, Mark T. Butt, D.V.M., Shelle A. Malkmus, B.S., R.V.T., Philip J. Richter, D.V.M., Kent G. Osborn, D.V.M., Qinghao Xu, Ph.D., Samantha L. Veesart, A.H.T., Joanne J. Steinauer, B.S., Denise Higgins, Douglas A. Lappi, Ph.D., Brian Russell, B.S., Tony L. Yaksh, Ph.D.

Anesthesiology. November 2013: 119(5):1163–1177

https://doi.org/10.1097/ALN.0b013e3182a95164

Published: November 2013

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Articles

Effects of General Anesthetics on Substance P Release and c-Fos Expression in the Spinal Dorsal Horn

Toshifumi Takasusuki, M.D., Ph.D., Shigeki Yamaguchi, M.D., Ph.D., Shinsuke Hamaguchi, M.D., Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. August 2013: 119(2):433–442

https://doi.org/10.1097/ALN.0b013e31829996b6

Published: August 2013

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Articles

Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat

Emre Hamurtekin, M.D., Ph.D., Bethany L. Fitzsimmons, M.Sc., Veronica I. Shubayev, M.D., Marjorie R. Grafe, M.D., Ph.D., Ronald Deumens, Ph.D., Tony L. Yaksh, Ph.D., Suellen M. Walker, M.B., B.S., Ph.D., F.A.N.Z.C.A.

Anesthesiology. July 2013: 119(1):142–155

https://doi.org/10.1097/ALN.0b013e31828fc7e7

Published: July 2013

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Articles

Role of Meningeal Mast Cells in Intrathecal Morphine–evoked Granuloma Formation

Tony L. Yaksh, Ph.D., Jeffery W. Allen, Ph.D., Samantha L. Veesart, L.A.T., Kjersti A. Horais, B.S., Shelle A. Malkmus, B.S., R.V.T., Miriam Scadeng, M.D., Joanne J. Steinauer, B.S., Steve S. Rossi, Ph.D.

Anesthesiology. March 2013: 118(3):664–678

https://doi.org/10.1097/ALN.0b013e31828351aa

Published: March 2013

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Articles

Safety Assessment and Pharmacokinetics of Intrathecal Methylprednisolone Acetate in Dogs

Mienke Rijsdijk, M.D., Albert J. M. van Wijck, M.D., Ph.D., Cor J. Kalkman, M.D., Ph.D., P. C. Willem Meulenhoff, M.Sc., Marjorie R. Grafe, M.D., Ph.D., Joanne Steinauer, B.S., Tony L. Yaksh, Ph.D.

Anesthesiology. January 2012: 116(1):170–181

https://doi.org/10.1097/ALN.0b013e31823cf035

Published: January 2012

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Articles

Regulation of Spinal Substance P Release by Intrathecal Calcium Channel Blockade

Toshifumi Takasusuki, M.D., Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. July 2011: 115(1):153–164

https://doi.org/10.1097/ALN.0b013e31821950c2

Published: July 2011

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Articles

Sublethal Spinal Ketamine Produces Neuronal Apoptosis in Rat Pups

Suellen M. Walker, M.B.B.S., Ph.D., F.A.N.Z.C.A., Marjorie Grafe, M.D., Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. March 2011: 114(3):719–721

https://doi.org/10.1097/ALN.0b013e31820a86b3

Published: March 2011

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Articles

Validation of a Preclinical Spinal Safety Model: Effects of Intrathecal Morphine in the Neonatal Rat

B. David Westin, M.D., Suellen M. Walker, M.B.B.S., Ph.D., F.A.N.Z.C.A., Ronald Deumens, Ph.D., Marjorie Grafe, M.D., Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. July 2010: 113(1):183–199

https://doi.org/10.1097/ALN.0b013e3181dcd6ec

Published: July 2010

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Articles

Effects of Intrathecal Ketamine in the Neonatal Rat: Evaluation of Apoptosis and Long-term Functional Outcome

Suellen M. Walker, M.B.B.S., Ph.D., F.A.N.Z.C.A., B. David Westin, M.D., Ronald Deumens, Ph.D., Marjorie Grafe, M.D., Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. July 2010: 113(1):147–159

https://doi.org/10.1097/ALN.0b013e3181dcd71c

Published: July 2010

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Articles

Effects of Intrathecal Ketorolac on Human Experimental Pain

James C. Eisenach, M.D., Regina Curry, R.N., Chuanyao Tong, M.D., Timothy T. Houle, Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. May 2010: 112(5):1216–1224

https://doi.org/10.1097/ALN.0b013e3181d94d8b

Published: May 2010

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Articles

Role of Spinal Cyclooxygenase in Human Postoperative and Chronic Pain

James C. Eisenach, M.D., Regina Curry, R.N., Richard Rauck, M.D., Peter Pan, M.D., Tony L. Yaksh, Ph.D.

Anesthesiology. May 2010: 112(5):1225–1233

https://doi.org/10.1097/ALN.0b013e3181d94dc0

Published: May 2010

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Articles

Preclinical Research on Persistent Postsurgical Pain: What We Don't Know, but Should Start Studying

Joachim Scholz, M.D., Tony L. Yaksh, Ph.D.

Anesthesiology. March 2010: 112(3):511–513

https://doi.org/10.1097/ALN.0b013e3181cf4266

Published: March 2010

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Articles

Randomized, Double-blind, Placebo-controlled, Dose-response, and Preclinical Safety Study of Transforaminal Epidural Etanercept for the Treatment of Sciatica

Steven P. Cohen, M.D., Nikolai Bogduk, M.D., Ph.D., Anthony Dragovich, M.D., Chester C. Buckenmaier, M.D., Scott Griffith, M.D., Connie Kurihara, R.N., JoLynne Raymond, D.V.M., Philip J. Richter, D.V.M., Ph.D., Necia Williams, M.D., Tony L. Yaksh, Ph.D.

Anesthesiology. May 2009: 110(5):1116–1126

https://doi.org/10.1097/ALN.0b013e3181a05aa0

Published: May 2009

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Articles

Toxicology Profile of N -Methyl-d-aspartate Antagonists Delivered by Intrathecal Infusion in the Canine Model

Tony L. Yaksh, Ph.D., Nicolle Tozier, Kjersti A. Horais, B.S., Shelle Malkmus, R.V.T., Michael Rathbun, Lisa LaFranco, D.V.M., James Eisenach, M.D.

Anesthesiology. May 2008: 108(5):938–949

https://doi.org/10.1097/ALN.0b013e31816c902a

Published: May 2008

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Articles

Time Course and Role of Morphine Dose and Concentration in Intrathecal Granuloma Formation in Dogs: A Combined Magnetic Resonance Imaging and Histopathology Investigation

Jeffrey W. Allen, Ph.D., Kjersti A. Horais, B.S., Nicolle A. Tozier, Kirsten Wegner, D.V.M., Jacqueline A. Corbeil, B.S., Robert F. Mattrey, M.D., Steven S. Rossi, Ph.D., Tony L. Yaksh, Ph.D.

Anesthesiology. September 2006: 105(3):581–589

https://doi.org/10.1097/00000542-200609000-00024

Published: September 2006

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Articles

Opiate Pharmacology of Intrathecal Granulomas

Jeffrey W. Allen, Ph.D., Kjersti A. Horais, B.S., Nicolle A. Tozier, Tony L. Yaksh, Ph.D.

Anesthesiology. September 2006: 105(3):590–598

https://doi.org/10.1097/00000542-200609000-00025

Published: September 2006

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Articles

Intrathecal Opioid Infusions

Tony L. Yaksh, Ph.D., Jeffrey W. Allen, Ph.D.

Anesthesiology. July 2004: 101(1):257–258

https://doi.org/10.1097/00000542-200407000-00044

Published: July 2004

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NARROW

Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling

Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation

Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs

Intrathecal Substance P-Saporin in the Dog: Distribution, Safety, and Spinal Neurokinin-1 Receptor Ablation

Effects of General Anesthetics on Substance P Release and c-Fos Expression in the Spinal Dorsal Horn

Evaluation of Spinal Toxicity and Long-term Spinal Reflex Function after Intrathecal Levobupivaciane in the Neonatal Rat

Role of Meningeal Mast Cells in Intrathecal Morphine–evoked Granuloma Formation

Safety Assessment and Pharmacokinetics of Intrathecal Methylprednisolone Acetate in Dogs

Regulation of Spinal Substance P Release by Intrathecal Calcium Channel Blockade

Sublethal Spinal Ketamine Produces Neuronal Apoptosis in Rat Pups

Validation of a Preclinical Spinal Safety Model: Effects of Intrathecal Morphine in the Neonatal Rat

Effects of Intrathecal Ketamine in the Neonatal Rat: Evaluation of Apoptosis and Long-term Functional Outcome

Effects of Intrathecal Ketorolac on Human Experimental Pain

Role of Spinal Cyclooxygenase in Human Postoperative and Chronic Pain

Preclinical Research on Persistent Postsurgical Pain: What We Don't Know, but Should Start Studying

Randomized, Double-blind, Placebo-controlled, Dose-response, and Preclinical Safety Study of Transforaminal Epidural Etanercept for the Treatment of Sciatica

Toxicology Profile of N -Methyl-d-aspartate Antagonists Delivered by Intrathecal Infusion in the Canine Model

Time Course and Role of Morphine Dose and Concentration in Intrathecal Granuloma Formation in Dogs: A Combined Magnetic Resonance Imaging and Histopathology Investigation

Opiate Pharmacology of Intrathecal Granulomas

Intrathecal Opioid Infusions

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