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John W. Severinghaus, M.D., 1922 to 2021

Philip E. Bickler, M.D., Ph.D., Thomas Hornbein, M.D., Lawrence J. Saidman, M.D.

Anesthesiology. October 2021: 135(4):555–557

DOI: https://doi.org/10.1097/ALN.0000000000003927

Published: October 2021

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Articles

“Silent” Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19

Philip E. Bickler, M.D., Ph.D., John R. Feiner, M.D., Michael S. Lipnick, M.D., William McKleroy, M.D.

Anesthesiology. February 2021: 134(2):262–269

DOI: https://doi.org/10.1097/ALN.0000000000003578

Published: February 2021

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Articles

Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion

Aaron Louie, B.S., John R. Feiner, M.D., Philip E. Bickler, M.D., Ph.D., Laura Rhodes, B.S., Michael Bernstein, B.S., Jennifer Lucero, M.D.

Anesthesiology. March 2018: 128(3):520–530

DOI: https://doi.org/10.1097/ALN.0000000000002002

Published: March 2018

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Articles

Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance

Andrew Schober, M.D., Ph.D., John R. Feiner, M.D., Philip E. Bickler, M.D., Ph.D., Mark D. Rollins, M.D., Ph.D.

Anesthesiology. January 2018: 128(1):97–108

DOI: https://doi.org/10.1097/ALN.0000000000001898

Published: January 2018

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Articles

Xenon Neurotoxicity in Rat Hippocampal Slice Cultures Is Similar to Isoflurane and Sevoflurane

Heather Brosnan, B.S., Philip E. Bickler, M.D., Ph.D.

Anesthesiology. August 2013: 119(2):335–344

DOI: https://doi.org/10.1097/ALN.0b013e31829417f0

Published: August 2013

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Articles

Propofol at Clinically Relevant Concentrations Increases Neuronal Differentiation But Is Not Toxic to Hippocampal Neural Precursor Cells In Vitro

Jeffrey W. Sall, M.D., Ph.D., Greg Stratmann, M.D., Ph.D., Jason Leong, Elliott Woodward, M.D., Philip E. Bickler, M.D., Ph.D.

Anesthesiology. November 2012: 117(5):1080–1090

DOI: https://doi.org/10.1097/ALN.0b013e31826f8d86

Published: November 2012

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Articles

Anesthetic Protection of Neurons Injured by Hypothermia and Rewarming: Roles of Intracellular Ca2+and Excitotoxicity

Philip E. Bickler, M.D., Ph.D., Daniel E. Warren, Ph.D., John P. Clark, Ph.D., Pablo Gabatto, B.S., Maren Gregersen, B.A., Heather Brosnan, B.S.

Anesthesiology. August 2012: 117(2):280–292

DOI: https://doi.org/10.1097/ALN.0b013e318260a7b9

Published: August 2012

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Articles

Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats

Jennifer Shih, B.A., Laura D. V. May, M.A., Heidi E. Gonzalez, B.A., Elaine W. Lee, B.A., Rehan S. Alvi, M.D., Jeffrey W. Sall, M.D., Ph.D., Vinuta Rau, Ph.D., Philip E. Bickler, M.D., Ph.D., Gopal R. Lalchandani, Marianna Yusupova, Elliott Woodward, M.D., Heejae Kang, B.A., Alan J. Wilk, B.A., Colleen M. Carlston, B.A., Mortay V. Mendoza, Jeremy N. Guggenheim, Maximilian Schaefer, M.D., Allison M. Rowe, B.A., Greg Stratmann, M.D., Ph.D.

Anesthesiology. March 2012: 116(3):586–602

DOI: https://doi.org/10.1097/ALN.0b013e318247564d

Published: March 2012

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Articles

Isoflurane Does Not Affect Brain Cell Death, Hippocampal Neurogenesis, or Long-term Neurocognitive Outcome in Aged Rats

Greg Stratmann, M.D., Ph.D., Jeffrey W. Sall, M.D., Ph.D., Joseph S. Bell, B.A., Rehan S. Alvi, M.D., Laura d. V. May, M.A., Ban Ku, B.A., Mitra Dowlatshahi, B.A., Ran Dai, B.A., Philip E. Bickler, M.D., Ph.D., Isobel Russell, M.D., Ph.D., Michael T. Lee, B.A., Margit W. Hrubos, B.S., Cheryl Chiu, B.A.

Anesthesiology. February 2010: 112(2):305–315

DOI: https://doi.org/10.1097/ALN.0b013e3181ca33a1

Published: February 2010

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Articles

Expression of Signal Transduction Genes Differs after Hypoxic or Isoflurane Preconditioning of Rat Hippocampal Slice Cultures

Philip E. Bickler, M.D., Ph.D., Christian S. Fahlman, Ph.D.

Anesthesiology. August 2009: 111(2):258–266

DOI: https://doi.org/10.1097/ALN.0b013e3181a8647f

Published: August 2009

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Articles

Anesthetic Neuroprotection: Some Things Do Last

Philip E. Bickler, M.D., Ph.D., Piyush M. Patel, M.D., Ph.D.

Anesthesiology. January 2007: 106(1):8–10

DOI: https://doi.org/10.1097/00000542-200701000-00006

Published: January 2007

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Articles

Isoflurane Neuroprotection in Rat Hippocampal Slices Decreases with Aging: Changes in Intracellular Ca2+Regulation and N-methyl-d-aspartate Receptor–mediated Ca2+Influx

Xinhua Zhan, M.D., Ph.D., Christian S. Fahlman, Ph.D., Philip E. Bickler, M.D., Ph.D.

Anesthesiology. May 2006: 104(5):995–1003

DOI: https://doi.org/10.1097/00000542-200605000-00016

Published: May 2006

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Articles

Isoflurane Preconditions Hippocampal Neurons against Oxygen–Glucose Deprivation: Role of Intracellular Ca2+and Mitogen-activated Protein Kinase Signaling

Philip E. Bickler, M.D., Ph.D., Xinhua Zhan, M.D., Ph.D., Christian S. Fahlman, Ph.D.

Anesthesiology. September 2005: 103(3):532–539

DOI: https://doi.org/10.1097/00000542-200509000-00016

Published: September 2005

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Articles

Effects of Skin Pigmentation on Pulse Oximeter Accuracy at Low Saturation

Philip E. Bickler, M.D., Ph.D., John R. Feiner, M.D., John W. Severinghaus, M.D.

Anesthesiology. April 2005: 102(4):715–719

DOI: https://doi.org/10.1097/00000542-200504000-00004

Published: April 2005

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Articles

Isoflurane Neuroprotection in Hypoxic Hippocampal Slice Cultures Involves Increases in Intracellular Ca 2+ and Mitogen-activated Protein Kinases

Jonathan J. Gray, B.S., Philip E. Bickler, M.D., Ph.D., Christian S. Fahlman, Ph.D., Xinhua Zhan, M.D., Ph.D., Jennifer A. Schuyler, B.S.

Anesthesiology. March 2005: 102(3):606–615

DOI: https://doi.org/10.1097/00000542-200503000-00020

Published: March 2005

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Articles

Isoflurane Prevents Delayed Cell Death in an Organotypic Slice Culture Model of Cerebral Ischemia

Breandan L. Sullivan, B.S., David Leu, B.S., Donald M. Taylor, M.D., Ph.D., Christian S. Fahlman, Ph.D., Philip E. Bickler, M.D., Ph.D.

Anesthesiology. January 2002: 96(1):189–195

DOI: https://doi.org/10.1097/00000542-200201000-00033

Published: January 2002

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Articles

Anesthetics and Mild Hypothermia Similarly Prevent Hippocampal Neuron Death in an In Vitro Model of Cerebral Ischemia

Robert Popovic, M.D., Richard Liniger, B.S., Philip E. Bickler, M.D., Ph.D.

Anesthesiology. May 2000: 92(5):1343–1349

DOI: https://doi.org/10.1097/00000542-200005000-00024

Published: May 2000

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Articles

Volatile Anesthetics Increase Intracellular Calcium in Cerebrocortical and Hippocampal Neurons

Christoph H. Kindler, MD, Helge Eilers, MD, Paul Donohoe, PhD, Surhan Ozer, MD, Philip E. Bickler, MD, PhD

Anesthesiology. April 1999: 90(4):1137–1145

DOI: https://doi.org/10.1097/00000542-199904000-00029

Published: April 1999

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Articles

Hypothermia and Isoflurane Similarly Inhibit Glutamate Release Evoked by Chemical Anoxia in Rat Cortical Brain Slices

Helge Eilers, MD, Philip E. Bickler, MD, PhD

Anesthesiology. September 1996: 85(3):600–607.

DOI: https://doi.org/10.1097/00000542-199609000-00020

Published: September 1996

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Articles

Volatile and Intravenous Anesthetics Decrease Glutamate Release from Cortical Brain Slices during Anoxia

Philip E. Bickler, MD, PhD, Leslie T. Buck, PhD, John R. Feiner, MD

Anesthesiology. December 1995: 83(6):1233–1240

DOI: https://doi.org/10.1097/00000542-199512000-00014

Published: December 1995

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NARROW

John W. Severinghaus, M.D., 1922 to 2021

“Silent” Presentation of Hypoxemia and Cardiorespiratory Compensation in COVID-19

Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion

Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance

Xenon Neurotoxicity in Rat Hippocampal Slice Cultures Is Similar to Isoflurane and Sevoflurane

Propofol at Clinically Relevant Concentrations Increases Neuronal Differentiation But Is Not Toxic to Hippocampal Neural Precursor Cells In Vitro

Anesthetic Protection of Neurons Injured by Hypothermia and Rewarming: Roles of Intracellular Ca2+and Excitotoxicity

Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats

Isoflurane Does Not Affect Brain Cell Death, Hippocampal Neurogenesis, or Long-term Neurocognitive Outcome in Aged Rats

Expression of Signal Transduction Genes Differs after Hypoxic or Isoflurane Preconditioning of Rat Hippocampal Slice Cultures

Anesthetic Neuroprotection: Some Things Do Last

Isoflurane Neuroprotection in Rat Hippocampal Slices Decreases with Aging: Changes in Intracellular Ca2+Regulation and N-methyl-d-aspartate Receptor–mediated Ca2+Influx

Isoflurane Preconditions Hippocampal Neurons against Oxygen–Glucose Deprivation: Role of Intracellular Ca2+and Mitogen-activated Protein Kinase Signaling

Effects of Skin Pigmentation on Pulse Oximeter Accuracy at Low Saturation

Isoflurane Neuroprotection in Hypoxic Hippocampal Slice Cultures Involves Increases in Intracellular Ca 2+ and Mitogen-activated Protein Kinases

Isoflurane Prevents Delayed Cell Death in an Organotypic Slice Culture Model of Cerebral Ischemia

Anesthetics and Mild Hypothermia Similarly Prevent Hippocampal Neuron Death in an In Vitro Model of Cerebral Ischemia

Volatile Anesthetics Increase Intracellular Calcium in Cerebrocortical and Hippocampal Neurons

Hypothermia and Isoflurane Similarly Inhibit Glutamate Release Evoked by Chemical Anoxia in Rat Cortical Brain Slices

Volatile and Intravenous Anesthetics Decrease Glutamate Release from Cortical Brain Slices during Anoxia

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