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Paul M. Heerdt
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Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

John J. Savarese, M.D., Hiroshi Sunaga, M.D., Jeff D. McGilvra, Ph.D., Matthew R. Belmont, M.D., Matthew T. Murrell, M.D., Ph.D., Erin Jeannotte, L.V.T., R.Lat.G., Farrell E. Cooke, B.S., William B. Wastila, Ph.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. November 2018: 129(5):970–988
DOI: https://doi.org/10.1097/ALN.0000000000002408
Published: November 2018
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Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Josh D. Kaullen, Pharm.D., Joel S. Owen, Ph.D., Kim L. R. Brouwer, Pharm.D., Ph.D., Paul M. Heerdt, M.D., Ph.D., Cynthia A. Lien, M.D., John J. Savarese, M.D., Virginia D. Schmith, Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2018: 128(6):1107–1116
DOI: https://doi.org/10.1097/ALN.0000000000002157
Published: June 2018
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Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man

Paul M. Heerdt, M.D., Ph.D., Hiroshi Sunaga, M.D., Joel S. Owen, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Deena Godfrey, B.A., Michelle Steinkamp, R.N., Peter Savard, M.D., John J. Savarese, M.D., Cynthia A. Lien, M.D.
Publication: Anesthesiology
Anesthesiology. December 2016: 125(6):1136–1143
DOI: https://doi.org/10.1097/ALN.0000000000001386
Published: December 2016
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Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat

Hiroshi Sunaga, M.D., John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Paul M. Heerdt, M.D., Ph.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Peter M. Savard, M.D., Erin Jeannotte, L.V.T., R.Lat.G., Bryce J. Petty, B.A., Erica Allen, Ph.D., Gilbert W. Carnathan, Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2016: 125(4):732–743
DOI: https://doi.org/10.1097/ALN.0000000000001254
Published: October 2016
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Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011

John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Hiroshi Sunaga, M.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Peter M. Savard, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2010: 113(1):58–73
DOI: https://doi.org/10.1097/ALN.0b013e3181dc1b5b
Published: July 2010
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Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs: Pharmacodynamics, Acute Cardiovascular Effects, and Preliminary Toxicology

Hiroshi Sunaga, M.D., Jaideep K. Malhotra, M.D., Edward Yoon, B.S., John J. Savarese, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):900–909
DOI: https://doi.org/10.1097/ALN.0b013e3181d31f8c
Published: April 2010
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Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs

Paul M. Heerdt, M.D., Ph.D., Jaideep K. Malhotra, M.D., Brian Y. Pan, B.S., Hiroshi Sunaga, M.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):910–916
DOI: https://doi.org/10.1097/ALN.0b013e3181d31f71
Published: April 2010
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Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine

Paul M. Heerdt, M.D., Ph.D., Paul Lane, Ph.D., Brian Y. Pan, B.S., Ulrich Schaefer, M.D., Mark Crabtree, Ph.D., Roger Hong, B.S., Andrew A. M. Singer, B.S., Roberto Levi, M.D., Bernard J. Park, M.D.
Publication: Anesthesiology
Anesthesiology. December 2007: 107(6):954–962
DOI: https://doi.org/10.1097/01.anes.0000291446.70921.61
Published: December 2007
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GW280430A: Pharmacodynamics and Potential Adverse Effects

Cynthia A. Lien, M.D., Matthew R. Belmont, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2005: 102(4):861–862
DOI: https://doi.org/10.1097/00000542-200504000-00025
Published: April 2005
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Anesthesia and Multiorgan Protein Remodeling

Paul M. Heerdt, M.D., Ph.D., F.A.H.A.
Publication: Anesthesiology
Anesthesiology. October 2004: 101(4):1040
DOI: https://doi.org/10.1097/00000542-200410000-00042
Published: October 2004
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Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs

Paul M. Heerdt, M.D., Ph.D., Richard Kang, B.S., Andrew The’, B.S., Mir Hashim, Ph.D., Robert J. Mook, Ph.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2004: 100(4):846–851
DOI: https://doi.org/10.1097/00000542-200404000-00014
Published: April 2004
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