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John J Savarese, M.D.
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Articles

Preclinical Pharmacology in the Rhesus Monkey of CW 1759-50, a New Ultra-short Acting Nondepolarizing Neuromuscular Blocking Agent, Degraded and Antagonized by L-Cysteine

John J. Savarese, M.D., Hiroshi Sunaga, M.D., Jeff D. McGilvra, Ph.D., Matthew R. Belmont, M.D., Matthew T. Murrell, M.D., Ph.D., Erin Jeannotte, L.V.T., R.Lat.G., Farrell E. Cooke, B.S., William B. Wastila, Ph.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. November 2018: 129(5):970–988
DOI: https://doi.org/10.1097/ALN.0000000000002408
Published: November 2018
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Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers

Josh D. Kaullen, Pharm.D., Joel S. Owen, Ph.D., Kim L. R. Brouwer, Pharm.D., Ph.D., Paul M. Heerdt, M.D., Ph.D., Cynthia A. Lien, M.D., John J. Savarese, M.D., Virginia D. Schmith, Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2018: 128(6):1107–1116
DOI: https://doi.org/10.1097/ALN.0000000000002157
Published: June 2018
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Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man

Paul M. Heerdt, M.D., Ph.D., Hiroshi Sunaga, M.D., Joel S. Owen, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Deena Godfrey, B.A., Michelle Steinkamp, R.N., Peter Savard, M.D., John J. Savarese, M.D., Cynthia A. Lien, M.D.
Publication: Anesthesiology
Anesthesiology. December 2016: 125(6):1136–1143
DOI: https://doi.org/10.1097/ALN.0000000000001386
Published: December 2016
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Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine—Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat

Hiroshi Sunaga, M.D., John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Paul M. Heerdt, M.D., Ph.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Matthew T. Murrell, M.D., Ph.D., Jaideep K. Malhotra, M.D., Peter M. Savard, M.D., Erin Jeannotte, L.V.T., R.Lat.G., Bryce J. Petty, B.A., Erica Allen, Ph.D., Gilbert W. Carnathan, Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2016: 125(4):732–743
DOI: https://doi.org/10.1097/ALN.0000000000001254
Published: October 2016
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Rapid Chemical Antagonism of Neuromuscular Blockade by l-Cysteine Adduction to and Inactivation of the Olefinic (Double-bonded) Isoquinolinium Diester Compounds Gantacurium (AV430A), CW 002, and CW 011

John J. Savarese, M.D., Jeff D. McGilvra, Ph.D., Hiroshi Sunaga, M.D., Matthew R. Belmont, M.D., Scott G. Van Ornum, Ph.D., Peter M. Savard, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2010: 113(1):58–73
DOI: https://doi.org/10.1097/ALN.0b013e3181dc1b5b
Published: July 2010
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Gantacurium and CW002 Do Not Potentiate Muscarinic Receptor-mediated Airway Smooth Muscle Constriction in Guinea Pigs

Hiroshi Sunaga, M.D., Yi Zhang, M.D., John J. Savarese, M.D., Charles W. Emala, M.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):892–899
DOI: https://doi.org/10.1097/ALN.0b013e3181d32016
Published: April 2010
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Cysteine Reversal of the Novel Neuromuscular Blocking Drug CW002 in Dogs: Pharmacodynamics, Acute Cardiovascular Effects, and Preliminary Toxicology

Hiroshi Sunaga, M.D., Jaideep K. Malhotra, M.D., Edward Yoon, B.S., John J. Savarese, M.D., Paul M. Heerdt, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):900–909
DOI: https://doi.org/10.1097/ALN.0b013e3181d31f8c
Published: April 2010
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Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs

Paul M. Heerdt, M.D., Ph.D., Jaideep K. Malhotra, M.D., Brian Y. Pan, B.S., Hiroshi Sunaga, M.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2010: 112(4):910–916
DOI: https://doi.org/10.1097/ALN.0b013e3181d31f71
Published: April 2010
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GW280430A: Pharmacodynamics and Potential Adverse Effects

John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2005: 102(4):863–865
DOI: https://doi.org/10.1097/00000542-200504000-00027
Published: April 2005
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Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs

Paul M. Heerdt, M.D., Ph.D., Richard Kang, B.S., Andrew The’, B.S., Mir Hashim, Ph.D., Robert J. Mook, Ph.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2004: 100(4):846–851
DOI: https://doi.org/10.1097/00000542-200404000-00014
Published: April 2004
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Clinical Pharmacology of GW280430A in Humans

Matthew R. Belmont, M.D., Cynthia A. Lien, M.D., Joseph Tjan, M.D., Eleanor Bradley, C.R.N.A., Brenna Stein, C.R.N.A., Sanjay S. Patel, Ph.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. April 2004: 100(4):768–773
DOI: https://doi.org/10.1097/00000542-200404000-00004
Published: April 2004
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Preclinical Pharmacology of GW280430A (AV430A) in the Rhesus Monkey and in the Cat: A Comparison with Mivacurium

John J. Savarese, M.D., Matthew R. Belmont, M.D., Mir A. Hashim, Ph.D., Robert A. Mook, Ph.D., Eric E. Boros, Ph.D., Vicente Samano, Ph.D., Sanjay S. Patel, Ph.D., Paul L. Feldman, Ph.D., Jan-Ake I. Schultz, M.D., Michael McNulty, Ph.D., Timothy Spitzer, Ph.D., Douglas L. Cohn, D.V.M., Philip Morgan, Ph.D., William B. Wastila, Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2004: 100(4):835–845
DOI: https://doi.org/10.1097/00000542-200404000-00013
Published: April 2004
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The Phamtacokinetics and Pharmacodynamics of the Stereoisomers of Mivacurium in Patients Receiving Nitrous Oxide/Opioid/Barbiturate Anesthesia

Cynthia A. Lien, M.D., Virginia D. Schmith, Ph.D., Patricia B. Embree, C.R.N.A., Matthew R. Belmont, M.D., William A. Wargin, Ph.D., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. June 1994: 80(6):1296–1302
DOI: https://doi.org/10.1097/00000542-199406000-00017
Published: June 1994
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The Cardiovascular Effects of Mivacurium Chloride (BW B1090U) in Patients Receiving Nitrous Oxide—Opiate—Barbiturate Anesthesia

John J. Savarese, M.D., Hassan H. Ali, M.D., Salvatore J. Basta, M.D., Ralph P. F. Scott, M.D., Patricia B. Embree, C.R.N.A., William B. Wastlla, Ph.D., Martha M. Abou-Donia, Ph.D., Carol Gelb, B.S.
Publication: Anesthesiology
Anesthesiology. March 1989: 70(3):386–394
DOI: https://doi.org/10.1097/00000542-198903000-00003
Published: March 1989
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Neuromuscular and Cardiovascular Effects of Mivacurium in Children

Nishan G. Goudsouzlan, M.D., James K. Alifimoff, M.D., Catherine Eberly, B.Sc., Regina Smeets, Drs., Jonathan Griswold, M.D., Veronica Miler, M.D., Barbara F. McNulty, M.P.H., John J. Savarese, M.D.
Publication: Anesthesiology
Anesthesiology. February 1989: 70(2):237–242
DOI: https://doi.org/10.1097/00000542-198902000-00010
Published: February 1989
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Calculating the Potency of Mivacurium: In Reply

JOHN J. SAVARESE, M.D.
Publication: Anesthesiology
Anesthesiology. January 1989: 70(1):166
DOI: https://doi.org/10.1097/00000542-198901000-00044
Published: January 1989
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Clinical Pharmacology of Doxacurium Chloride A New Long-acting Nondepolarlzlng Muscle Relaxant

Salvatore J. Basta, M.D., John J. Savarese, M.D., Hassan H. Ali, M.D., Patricia B. Embree, C.R.N.A., Ann F. Schwartz, C.R.N.A., G. David Rudd, M.S., William B. Wastila, Ph.D.
Publication: Anesthesiology
Anesthesiology. October 1988: 69(4):478–486
DOI: https://doi.org/10.1097/00000542-198810000-00006
Published: October 1988
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A QUANTAL ANALYSIS OF THE DOSE-RESPONSE OF MIVACURIUM FOR PLASMA HISTAMINE INCREASE, FACIAL ERYTHEMA AND ARTERIAL PRESSURE DECREASE

John J. Savarese, M.D., Carl E. Rosou, M.D., Ph. D., Patricia B. Embree, CRNA., Ann F. Schwartz, CRNA., Salvatore J. Basta, M.D.
Publication: Anesthesiology
Anesthesiology. September 1988: 69(3A):A527
DOI: https://doi.org/10.1097/00000542-198809010-00527
Published: September 1988
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COMPARISON OF SPONTANEOUS RECOVERY AND NEOSTIGHINE-ACCELERATED RECOVERY FROM HIVACURIUM NEUROMUSCULAR BLOCKADE

Michael J. Cut-ran, M.D., Leslie Shaff, M.D., John J. Savarese, M.D., Hassan H. Ali, M.D., Marcus Risner, Ph. D.
Publication: Anesthesiology
Anesthesiology. September 1988: 69(3A):A528
DOI: https://doi.org/10.1097/00000542-198809010-00528
Published: September 1988
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The Clinical Neuromuscular Pharmacology of Mivacurium Chloride (BW B1090U). A Short-acting Nondepolarizing Ester Neuromuscular Blocking Drug

John J. Savarese, M.D., Hassan H. Ali, M.D., Salvatore J. Basta, M.D., Patricia B. Embree, C.R.N.A., Ralph P. F. Scott, M.D., N. Sunder, M.D., J. Neal Weakly, Ph.D., William B. Wastilla, Ph.D., Hassan A. El-Sayad, Ph.D.
Publication: Anesthesiology
Anesthesiology. May 1988: 68(5):723–732
DOI: https://doi.org/10.1097/00000542-198805000-00010
Published: May 1988
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