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Articles

Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers

Kelly Jonkman, M.D., Andreas Duma, M.D., Erik Olofsen, M.Sc., Thomas Henthorn, M.D., Monique van Velzen, Ph.D., René Mooren, B.Sc., Liesbeth Siebers, B.Sc., Jojanneke van den Beukel, B.Sc., Leon Aarts, M.D., Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. October 2017: 127(4):675–683

DOI: https://doi.org/10.1097/ALN.0000000000001798

Published: October 2017

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Articles

An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Douglas J. Eleveld, Ph.D., Johannes H. Proost, Pharm.D., Hugo Vereecke, M.D., Ph.D., Anthony R. Absalom, M.D., Ph.D., Erik Olofsen, M.Sc., Jaap Vuyk, M.D., Ph.D., Michel M. R. F. Struys, M.D., Ph.D.

Anesthesiology. June 2017: 126(6):1005–1018

DOI: https://doi.org/10.1097/ALN.0000000000001634

Published: June 2017

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Articles

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Albert Dahan, M.D., Ph.D., Merel Boom, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Justin Hay, Ph.D., Geert Jan Groeneveld, M.D., Ph.D., Meike Neukirchen, Ph.D., John Bothmer, Ph.D., Leon Aarts, M.D., Ph.D., Erik Olofsen, M.Sc.

Anesthesiology. April 2017: 126(4):697–707

DOI: https://doi.org/10.1097/ALN.0000000000001529

Published: April 2017

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Articles

Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals

Rutger van der Schrier, M.D., Margot Roozekrans, M.D., Erik Olofsen, M.Sc., Leon Aarts, M.D., Ph.D., Monique van Velzen, Ph.D., Merijn de Jong, B.Sc., Albert Dahan, M.D., Ph.D., Marieke Niesters, M.D., Ph.D.

Anesthesiology. March 2017: 126(3):534–542

DOI: https://doi.org/10.1097/ALN.0000000000001505

Published: March 2017

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Articles

Big Brain, Small World?

Erik Olofsen, M.Sc., Albert Dahan, M.D., Ph.D.

Anesthesiology. January 2015: 122(1):8–11

DOI: https://doi.org/10.1097/ALN.0000000000000517

Published: January 2015

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Articles

Fentanyl Utility Function: A Risk–Benefit Composite of Pain Relief and Breathing Responses

Merel Boom, M.D., Erik Olofsen, M.Sc., Meike Neukirchen, Ph.D., René Fussen, Dr. Med., M.D., Justin Hay, Ph.D., Geert Jan Groeneveld, M.D., Ph.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. September 2013: 119(3):663–674

DOI: https://doi.org/10.1097/ALN.0b013e31829ce4cb

Published: September 2013

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Articles

Estimation of the Contribution of Norketamine to Ketamine-induced Acute Pain Relief and Neurocognitive Impairment in Healthy Volunteers

Erik Olofsen, M.Sc., Ingeborg Noppers, M.D., Ph.D., Marieke Niesters, M.D., M.Sc., Evan Kharasch, M.D., Ph.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. August 2012: 117(2):353–364

DOI: https://doi.org/10.1097/ALN.0b013e31825b6c91

Published: August 2012

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Articles

Effect of Rifampicin on S-ketamine and S-norketamine Plasma Concentrations in Healthy Volunteers after Intravenous S-ketamine Administration

Ingeborg Noppers, M.D., Erik Olofsen, M.Sc., Marieke Niesters, M.D., M.Sc., Leon Aarts, M.D., Ph.D., René Mooren, B.Sc., Albert Dahan, M.D., Ph.D., Evan Kharasch, M.D., Ph.D., Elise Sarton, M.D., Ph.D.

Anesthesiology. June 2011: 114(6):1435–1445

DOI: https://doi.org/10.1097/ALN.0b013e318218a881

Published: June 2011

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Articles

Opioid Modeling of Central Respiratory Drive Must Take Upper Airway Obstruction into Account

Erik Olofsen, M.Sc., Albert Dahan, M.D., Ph.D.

Anesthesiology. January 2011: 114(1):220–221

DOI: https://doi.org/10.1097/ALN.0b013e3181ff2325

Published: January 2011

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Articles

Modeling the Non–Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers

Erik Olofsen, M.Sc., Merel Boom, M.D., Diederik Nieuwenhuijs, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Luc Teppema, Ph.D., Leon Aarts, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. June 2010: 112(6):1382–1395

DOI: https://doi.org/10.1097/ALN.0b013e3181d69087

Published: June 2010

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Articles

Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers: A Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling Study

Erik Olofsen, M.Sc., Eveline van Dorp, M.D., Ph.D., Luc Teppema, Ph.D., Leon Aarts, M.D., Ph.D., Terry W. Smith, Ph.D., Albert Dahan, M.D., Ph.D., Elise Sarton, M.D., Ph.D.

Anesthesiology. June 2010: 112(6):1417–1427

DOI: https://doi.org/10.1097/ALN.0b013e3181d5e29d

Published: June 2010

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Articles

S(+)-ketamine Effect on Experimental Pain and Cardiac Output: A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers

Marnix Sigtermans, M.D., Albert Dahan, M.D., Ph.D., René Mooren, B.Sc., Martin Bauer, M.D., Benjamin Kest, Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, M.Sc.

Anesthesiology. October 2009: 111(4):892–903

DOI: https://doi.org/10.1097/ALN.0b013e3181b437b1

Published: October 2009

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Articles

Population Pharmacokinetic–Pharmacodynamic Modeling of Epidural Anesthesia

Erik Olofsen, M.Sc., Antonius G. L. Burm, Ph.D., Mischa J. G. Simon, M.D., Ph.D., Bernadette Th. Veering, M.D., Ph.D., Jack W. van Kleef, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. October 2008: 109(4):664–674

DOI: https://doi.org/10.1097/01.anes.0000334302.50559.c9

Published: October 2008

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Articles

Naloxone Reversal of Buprenorphine-induced Respiratory Depression

Eveline van Dorp, M.D., Ashraf Yassen, M.Sc., Elise Sarton, M.D., Ph.D., Raymonda Romberg, M.D., Ph.D., Erik Olofsen, M.Sc., Luc Teppema, Ph.D., Meindert Danhof, Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. July 2006: 105(1):51–57

DOI: https://doi.org/10.1097/00000542-200607000-00012

Published: July 2006

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Articles

Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine in Healthy Volunteers

Ashraf Yassen, M.Sc., Erik Olofsen, M.Sc., Raymonda Romberg, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Meindert Danhof, Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. June 2006: 104(6):1232–1242

DOI: https://doi.org/10.1097/00000542-200606000-00019

Published: June 2006

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Articles

Alfentanil and Placebo Analgesia: No Sex Differences Detected in Models of Experimental Pain

Erik Olofsen, M.Sc., Raymonda Romberg, M.D., Ph.D., Hans Bijl, M.D., René Mooren, B.Sc., Frank Engbers, M.D., Benjamin Kest, Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. July 2005: 103(1):130–139

DOI: https://doi.org/10.1097/00000542-200507000-00020

Published: July 2005

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Articles

Polymorphism of μ-Opioid Receptor Gene ( OPRM1:c.118A>G ) Does Not Protect Against Opioid-induced Respiratory Depression despite Reduced Analgesic Response

Raymonda R. Romberg, M.D., Erik Olofsen, M.Sc., Hans Bijl, M.D., Peter E. M. Taschner, Ph.D., Luc J. Teppema, Ph.D., Elise Y. Sarton, M.D., Ph.D., Jack W. van Kleef, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. March 2005: 102(3):522–530

DOI: https://doi.org/10.1097/00000542-200503000-00008

Published: March 2005

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Articles

Simultaneous Measurement and Integrated Analysis of Analgesia and Respiration after an Intravenous Morphine Infusion

Albert Dahan, M.D., Ph.D., Raymonda Romberg, M.D., Luc Teppema, Ph.D., Elise Sarton, M.D., Ph.D., Hans Bijl, M.D., Erik Olofsen, M.Sc.

Anesthesiology. November 2004: 101(5):1201–1209

DOI: https://doi.org/10.1097/00000542-200411000-00021

Published: November 2004

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Articles

Increased Margin of Safety of Morphine-6-glucuronide Relative to Morphine

Raymonda Romberg, M.D., Erik Olofsen, M.Sc., Elise Sarton, M.D., Ph.D., Luc Teppema, Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. June 2004: 100(6):1622

DOI: https://doi.org/10.1097/00000542-200406000-00048

Published: June 2004

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Articles

Mixed-effects Modeling of the Influence of Alfentanil on Propofol Pharmacokinetics

Martijn J. Mertens, M.D., Ph.D., Erik Olofsen, M.Sc., Anton G. L. Burm, M.Sc., Ph.D., James G. Bovill, M.D., Ph.D., F.F.A.R.C.S.I., Jaap Vuyk, M.D., Ph.D.

Anesthesiology. April 2004: 100(4):795–805

DOI: https://doi.org/10.1097/00000542-200404000-00008

Published: April 2004

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NARROW

Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers

An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Influence of Ethanol on Oxycodone-induced Respiratory Depression: A Dose-escalating Study in Young and Elderly Individuals

Big Brain, Small World?

Fentanyl Utility Function: A Risk–Benefit Composite of Pain Relief and Breathing Responses

Estimation of the Contribution of Norketamine to Ketamine-induced Acute Pain Relief and Neurocognitive Impairment in Healthy Volunteers

Effect of Rifampicin on S-ketamine and S-norketamine Plasma Concentrations in Healthy Volunteers after Intravenous S-ketamine Administration

Opioid Modeling of Central Respiratory Drive Must Take Upper Airway Obstruction into Account

Modeling the Non–Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers

Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers: A Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling Study

S(+)-ketamine Effect on Experimental Pain and Cardiac Output: A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers

Population Pharmacokinetic–Pharmacodynamic Modeling of Epidural Anesthesia

Naloxone Reversal of Buprenorphine-induced Respiratory Depression

Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine in Healthy Volunteers

Alfentanil and Placebo Analgesia: No Sex Differences Detected in Models of Experimental Pain

Polymorphism of μ-Opioid Receptor Gene ( OPRM1:c.118A>G ) Does Not Protect Against Opioid-induced Respiratory Depression despite Reduced Analgesic Response

Simultaneous Measurement and Integrated Analysis of Analgesia and Respiration after an Intravenous Morphine Infusion

Increased Margin of Safety of Morphine-6-glucuronide Relative to Morphine

Mixed-effects Modeling of the Influence of Alfentanil on Propofol Pharmacokinetics

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