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Articles

Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine

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Pieter Simons, M.D., Rutger van der Schrier, M.D., Maarten van Lemmen, B.Sc., Simone Jansen, M.D., Kiki W.K. Kuijpers, B.Sc., Monique van Velzen, Ph.D., Elise Sarton, M.D., Ph.D., Todd Nicklas, M.S.N., Cathy Michalsky, M.Sc., Mark A. Demitrack, M.D., Michael Fossler, Pharm.D., Ph.D., F.C.P., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D. Ph.D.
Publication: Anesthesiology
Anesthesiology. March 2023: 138(3):249–263
DOI: https://doi.org/10.1097/ALN.0000000000004473
Published: March 2023
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Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression

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Hyke Algera, M.D., Rutger van der Schrier, M.D., David Cavalla, Ph.D., Monique van Velzen, Ph.D., Margot Roozekrans, M.D., Ph.D., Alison McMorn, Ph.D., Michael Snape, Ph.D., Joseph P. Horrigan, M.D., Stuart Evans, M.A., Bernard Kiernan, Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2022: 137(4):446–458
DOI: https://doi.org/10.1097/ALN.0000000000004324
Published: October 2022
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Ketamine Psychedelic and Antinociceptive Effects Are Connected

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Erik Olofsen, Ph.D., Jasper Kamp, Ph.D., Thomas K. Henthorn, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. May 2022: 136(5):792–801
DOI: https://doi.org/10.1097/ALN.0000000000004176
Published: May 2022
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Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity

Rutger van der Schrier, M.D., Jack D. C. Dahan, B.Sc., Martijn Boon, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. April 2022: 136(4):618–632
DOI: https://doi.org/10.1097/ALN.0000000000004096
Published: April 2022
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Analgesic and Respiratory Depressant Effects of R-dihydroetorphine: A Pharmacokinetic–Pharmacodynamic Analysis in Healthy Male Volunteers

Erik Olofsen, Ph.D., Merel Boom, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Paul Baily, B.Sc., Kevin J. Smith, Ph.D., Alexander Oksche, M.D., Ph.D., Albert Dahan, M.D., Ph.D., Marieke Niesters, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. December 2019: 131(6):1327–1339
DOI: https://doi.org/10.1097/ALN.0000000000002991
Published: December 2019
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Benefit versus Severe Side Effects of Opioid Analgesia: Novel Utility Functions of Probability of Analgesia and Respiratory Depression

Margot Roozekrans, M.D., Rutger van der Schrier, M.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D., Erik Olofsen, Ph.D.
Publication: Anesthesiology
Anesthesiology. May 2018: 128(5):932–942
DOI: https://doi.org/10.1097/ALN.0000000000002138
Published: May 2018
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Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Albert Dahan, M.D., Ph.D., Merel Boom, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Justin Hay, Ph.D., Geert Jan Groeneveld, M.D., Ph.D., Meike Neukirchen, Ph.D., John Bothmer, Ph.D., Leon Aarts, M.D., Ph.D., Erik Olofsen, M.Sc.
Publication: Anesthesiology
Anesthesiology. April 2017: 126(4):697–707
DOI: https://doi.org/10.1097/ALN.0000000000001529
Published: April 2017
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Fentanyl Utility Function: A Risk–Benefit Composite of Pain Relief and Breathing Responses

Merel Boom, M.D., Erik Olofsen, M.Sc., Meike Neukirchen, Ph.D., René Fussen, Dr. Med., M.D., Justin Hay, Ph.D., Geert Jan Groeneveld, M.D., Ph.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. September 2013: 119(3):663–674
DOI: https://doi.org/10.1097/ALN.0b013e31829ce4cb
Published: September 2013
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Estimation of the Contribution of Norketamine to Ketamine-induced Acute Pain Relief and Neurocognitive Impairment in Healthy Volunteers

Erik Olofsen, M.Sc., Ingeborg Noppers, M.D., Ph.D., Marieke Niesters, M.D., M.Sc., Evan Kharasch, M.D., Ph.D., Leon Aarts, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. August 2012: 117(2):353–364
DOI: https://doi.org/10.1097/ALN.0b013e31825b6c91
Published: August 2012
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Offset Analgesia in Neuropathic Pain Patients and Effect of Treatment with Morphine and Ketamine

Marieke Niesters, M.D., M.Sc., Elske Hoitsma, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Leon Aarts, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. November 2011: 115(5):1063–1071
DOI: https://doi.org/10.1097/ALN.0b013e31822fd03a
Published: November 2011
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Effect of Rifampicin on S-ketamine and S-norketamine Plasma Concentrations in Healthy Volunteers after Intravenous S-ketamine Administration

Ingeborg Noppers, M.D., Erik Olofsen, M.Sc., Marieke Niesters, M.D., M.Sc., Leon Aarts, M.D., Ph.D., René Mooren, B.Sc., Albert Dahan, M.D., Ph.D., Evan Kharasch, M.D., Ph.D., Elise Sarton, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2011: 114(6):1435–1445
DOI: https://doi.org/10.1097/ALN.0b013e318218a881
Published: June 2011
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Modeling the Non–Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers

Erik Olofsen, M.Sc., Merel Boom, M.D., Diederik Nieuwenhuijs, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Luc Teppema, Ph.D., Leon Aarts, M.D., Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2010: 112(6):1382–1395
DOI: https://doi.org/10.1097/ALN.0b013e3181d69087
Published: June 2010
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Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers: A Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling Study

Erik Olofsen, M.Sc., Eveline van Dorp, M.D., Ph.D., Luc Teppema, Ph.D., Leon Aarts, M.D., Ph.D., Terry W. Smith, Ph.D., Albert Dahan, M.D., Ph.D., Elise Sarton, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2010: 112(6):1417–1427
DOI: https://doi.org/10.1097/ALN.0b013e3181d5e29d
Published: June 2010
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S(+)-ketamine Effect on Experimental Pain and Cardiac Output: A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers

Marnix Sigtermans, M.D., Albert Dahan, M.D., Ph.D., René Mooren, B.Sc., Martin Bauer, M.D., Benjamin Kest, Ph.D., Elise Sarton, M.D., Ph.D., Erik Olofsen, M.Sc.
Publication: Anesthesiology
Anesthesiology. October 2009: 111(4):892–903
DOI: https://doi.org/10.1097/ALN.0b013e3181b437b1
Published: October 2009
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Naloxone Reversal of Buprenorphine-induced Respiratory Depression

Eveline van Dorp, M.D., Ashraf Yassen, M.Sc., Elise Sarton, M.D., Ph.D., Raymonda Romberg, M.D., Ph.D., Erik Olofsen, M.Sc., Luc Teppema, Ph.D., Meindert Danhof, Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. July 2006: 105(1):51–57
DOI: https://doi.org/10.1097/00000542-200607000-00012
Published: July 2006
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Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine in Healthy Volunteers

Ashraf Yassen, M.Sc., Erik Olofsen, M.Sc., Raymonda Romberg, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Meindert Danhof, Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2006: 104(6):1232–1242
DOI: https://doi.org/10.1097/00000542-200606000-00019
Published: June 2006
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Simultaneous Measurement and Integrated Analysis of Analgesia and Respiration after an Intravenous Morphine Infusion

Albert Dahan, M.D., Ph.D., Raymonda Romberg, M.D., Luc Teppema, Ph.D., Elise Sarton, M.D., Ph.D., Hans Bijl, M.D., Erik Olofsen, M.Sc.
Publication: Anesthesiology
Anesthesiology. November 2004: 101(5):1201–1209
DOI: https://doi.org/10.1097/00000542-200411000-00021
Published: November 2004
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Increased Margin of Safety of Morphine-6-glucuronide Relative to Morphine

Raymonda Romberg, M.D., Erik Olofsen, M.Sc., Elise Sarton, M.D., Ph.D., Luc Teppema, Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. June 2004: 100(6):1622
DOI: https://doi.org/10.1097/00000542-200406000-00048
Published: June 2004
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Pharmacokinetic-Pharmacodynamic Modeling of Morphine-6-glucuronide-induced Analgesia in Healthy Volunteers: Absence of Sex Differences

Raymonda Romberg, M.D., Erik Olofsen, M.Sc., Elise Sarton, M.D., Ph.D., Jan den Hartigh, Ph.D., Peter E. M. Taschner, Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. January 2004: 100(1):120–133
DOI: https://doi.org/10.1097/00000542-200401000-00021
Published: January 2004
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Pharmacodynamic Effect of Morphine-6-glucuronide versus   Morphine on Hypoxic and Hypercapnic Breathing in Healthy Volunteers

Raymonda Romberg, M.D., Erik Olofsen, M.Sc., Elise Sarton, M.D., Ph.D., Luc Teppema, Ph.D., Albert Dahan, M.D., Ph.D.
Publication: Anesthesiology
Anesthesiology. October 2003: 99(4):788–798
DOI: https://doi.org/10.1097/00000542-200310000-00008
Published: October 2003
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