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Articles

Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology

Charles F. Minto, F.A.N.Z.C.A., Ph.D., Talmage D. Egan, M.D., Thomas W. Schnider, Prof. Dr. med.

Anesthesiology. August 2023: 10.1097/ALN.0000000000004686

https://doi.org/10.1097/ALN.0000000000004686

Published: August 2023

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Articles

Using the Time of Maximum Effect Site Concentration to Combine Pharmacokinetics and Pharmacodynamics

Charles F. Minto, M.B., Ph.D., Thomas W. Schnider, M.D., Keith M. Gregg, Ph.D., Thomas K. Henthorn, M.D., Steven L. Shafer, M.D.

Anesthesiology. August 2003: 99(2):324–333

https://doi.org/10.1097/00000542-200308000-00014

Published: August 2003

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Articles

Efficient Trial Design for Eliciting a Pharmacokinetic– Pharmacodynamic Model–based Response Surface Describing the Interaction between Two Intravenous Anesthetic Drugs

Timothy G. Short, M.D., F.A.N.Z.C.A., Tam Yuk Ho, M.Phil., Charles F. Minto, M.B., Ch.B., F.A.N.Z.C.A., Thomas W. Schnider, P.D., Dr. med., Steven L. Shafer, M.D.

Anesthesiology. February 2002: 96(2):400–408

https://doi.org/10.1097/00000542-200202000-00027

Published: February 2002

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Articles

Response Surface Model for Anesthetic Drug Interactions

Charles F. Minto, M.B., Ch.B., Thomas W. Schnider, M.D., Timothy G. Short, M.D., Keith M. Gregg, Ph.D., Andrea Gentilini, M.S., Steven L. Shafer, M.D.

Anesthesiology. June 2000: 92(6):1603–1616

https://doi.org/10.1097/00000542-200006000-00017

Published: June 2000

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Articles

The Influence of Age on Propofol Pharmacodynamics

Thomas W. Schnider, DrMed, Charles F. Minto, MB, ChB, Steven L. Shafer, MD, Pedro L. Gambus, MD, Corina Andresen, MD, David B. Goodale, DDS, PhD, Elizabeth J. Youngs, MD

Anesthesiology. June 1999: 90(6):1502–1516.

https://doi.org/10.1097/00000542-199906000-00003

Published: June 1999

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Articles

The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers

Thomas W. Schnider, Dr med, Charles F. Minto, MB, ChB, Pedro L. Gambus, MD, Corina Andresen, MD, David B. Goodale, DDS, PhD, Steven L. Shafer, MD, Elizabeth J. Youngs, MD

Anesthesiology. May 1998: 88(5):1170–1182

https://doi.org/10.1097/00000542-199805000-00006

Published: May 1998

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Articles

Pharmacokinetics and Pharmacodynamics of Remifentanil: II. Model Application

Charles F. Minto, MB, ChB, Thomas W. Schnider, MD, Steven L. Shafer, MD

Anesthesiology. January 1997: 86(1):24–33

https://doi.org/10.1097/00000542-199701000-00005

Published: January 1997

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Articles

Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development

Charles F. Minto, MB, ChB, Thomas W. Schnider, MD, Talmage D. Egan, MD, Elizabeth Youngs, MD, Harry J. M. Lemmens, MD, Pedro L. Gambus, MD, Valerie Billard, MD, John F. Hoke, PhD, Katherine H. P. Moore, PharmD, David J. Hermann, PharmD, Keith T. Muir, PhD, Jaap W. Mandema, PhD, Steven L. Shafer, MD

Anesthesiology. January 1997: 86(1):10–23

https://doi.org/10.1097/00000542-199701000-00004

Published: January 1997

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Articles

Population Pharmacodynamic Modeling and Covariate Detection for Central Neural Blockade

Thomas W. Schnider, MD, Charles F. Minto, MBChB, Heini Bruckert, MD, Jaap W. Mandema, PhD

Anesthesiology. September 1996: 85(3):502–512.

https://doi.org/10.1097/00000542-199609000-00009

Published: September 1996

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Articles

Derivation and Cross-validation of Pharmacokinetic Parameters for Computer-controlled Infusion of Lidocaine in Pain Therapy

Thomas W. Schnider, MD, Raymond Gaeta, MD, William Brose, MD, Charles F. Minto, MBChB, Keith M. Gregg, MA, Steven L. Shafer, MD

Anesthesiology. May 1996: 84(5):1043–1050

https://doi.org/10.1097/00000542-199605000-00005

Published: May 1996

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Articles

Remifentanil Versus Alfentanil: Comparative Pharmacokinetics and Pharmacodynamics in Healthy Adult Male Volunteers

Talmage D. Egan, MD, Charles F. Minto, MD, David J. Hermann, PharmD, Juliana Barr, MD, Keith T. Muir, PhD, Steven L. Shafer, MD

Anesthesiology. April 1996: 84(4):821–833.

https://doi.org/10.1097/00000542-199604000-00009

Published: April 1996

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Articles

Semilinear Canonical Correlation Applied to the Measurement of the Electroencephalographic Effects of Midazolam and Flumazenil Reversal

Thomas W. Schnider, MD, Charles F. Minto, MBChB, Pierre Fiset, MD, Keith M. Gregg, MA, Steven L. Shafer, MD

Anesthesiology. March 1996: 84(3):510–519

https://doi.org/10.1097/00000542-199603000-00004

Published: March 1996

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NARROW

Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology

Using the Time of Maximum Effect Site Concentration to Combine Pharmacokinetics and Pharmacodynamics

Efficient Trial Design for Eliciting a Pharmacokinetic– Pharmacodynamic Model–based Response Surface Describing the Interaction between Two Intravenous Anesthetic Drugs

Response Surface Model for Anesthetic Drug Interactions

The Influence of Age on Propofol Pharmacodynamics

The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers

Pharmacokinetics and Pharmacodynamics of Remifentanil: II. Model Application

Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development

Population Pharmacodynamic Modeling and Covariate Detection for Central Neural Blockade

Derivation and Cross-validation of Pharmacokinetic Parameters for Computer-controlled Infusion of Lidocaine in Pain Therapy

Remifentanil Versus Alfentanil: Comparative Pharmacokinetics and Pharmacodynamics in Healthy Adult Male Volunteers

Semilinear Canonical Correlation Applied to the Measurement of the Electroencephalographic Effects of Midazolam and Flumazenil Reversal

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