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Online First
The editors of Anesthesiology are pleased to publish articles online ahead of print. Starting in 2022, Original Investigation articles will initially appear in a pre-proof format using the accepted version of the manuscript. The pre-proof will be replaced by the final version of the article that has been been copyedited, proofread, typeset, and reviewed by the author(s) but has not appeared in an issue of the journal. Each article published online ahead of print is citable in pre-proof or final version. The pre-proof cover sheet will note the citation text. Anesthesiology articles are assigned Digital Object Identifiers (DOIs), providing a persistent, permanent way to identify articles published in the online environment. Other article types will be posted Online First only when the final copyedited and approved version is available.
Just Accepted
Perioperative Medicine
Remimazolam dosing for gastroscopy: a randomized noninferiority trial
Huichen Zhu, M.D.; Zhongxue Su, M.S.; Hongmei Zhou, M.D., Ph.D.; Jian Lu, M.D.; Xiangrui Wang, M.D., Ph.D.; Zhonghua Ji, M.D.; Shibiao Chen, M.D., Ph.D.; Xiuhong Wang, M.D.; Ming Yao, M.D., Ph.D.; Yaping Lu, M.D.; Weifeng Yu, M.D., Ph.D.; Diansan Su, M.D., Ph.D.
Anesthesiology Newly Published on December 1, 2023. doi:https://doi.org/10.1097/ALN.0000000000004851
Perioperative Medicine
Movement-evoked pain versus pain at rest in postsurgical clinical trials, and, in meta-analyses: An updated systematic review
Ian Gilron, MD, MSc, FRCPC; Nicholas Lao, MSc; Meg Carley, BSc; Daenis Camiré, BScN, RN, MD, MSc, FRCPC; Henrik Kehlet, MD, PhD; Timothy J. Brennan, MD, PhD; Jason Erb, MD, FRCPC
Anesthesiology Newly Published on November 27, 2023. doi:https://doi.org/10.1097/ALN.0000000000004850
Perioperative Medicine
Intraoperative mechanical power and postoperative pulmonary complications in non-cardiothoracic elective surgery patients: a ten-year retrospective cohort-study
Bertrand Elefterion, MD; Cedric Cirenei, MD; Eric Kipnis, MD, PhD; Emeline Cailliau, BST; Amélie Bruandet, MD, PhD; Benoit Tavernier, MD, PhD; Antoine Lamer, PhD; Gilles Lebuffe, MD, PhD
Anesthesiology Newly Published on November 27, 2023. doi:https://doi.org/10.1097/ALN.0000000000004848
Perioperative Medicine
A Quality Improvement Initiative to Reduce Adverse Effects of Transitions of Anesthesia Care on Postoperative Outcomes: A Retrospective Cohort Study
Anesthesiology Newly Published on November 17, 2023. doi:https://doi.org/10.1097/ALN.0000000000004839
Perioperative Medicine
Opioid-free anesthesia protocol on the early quality of recovery after major surgery (SOFA trial): A randomized clinical trial
Maxime Léger, M.D., Ph.D.; Tristan Perrault, M.D.; Solène Pessiot-Royer, M.D.; Elsa Parot-Schinkel, M.D.; Fabienne Costerousse, M.D.; Emmanuel Rineau, M.D., Ph.D.; Sigismond Lasocki, M.D., Ph.D.
Anesthesiology Newly Published on November 17, 2023. doi:https://doi.org/10.1097/ALN.0000000000004840
Perioperative Medicine
The effect of extracerebral contamination on near infrared spectroscopy as revealed during organ donation: A prospective observational study in brain dead organ donors
Martin Soehle, M.D., Ph.D., MHBA; Juliane Langer, M.S.; Ehrenfried Schindler, M.D., Ph.D.; Steffen Manekeller, M.D., Ph.D.; Mark Coburn, M.D., Ph.D.; Marcus Thudium, M.D., Ph.D.
Anesthesiology Newly Published on November 7, 2023. doi:https://doi.org/10.1097/ALN.0000000000004828
Perioperative Medicine
Association of Patient Race and Hospital with Utilization of Regional Anesthesia for Treatment of Post-Operative Pain in Total Knee Arthroplasty: A Retrospective Analysis Using Medicare Claims
Anjali A. Dixit, MD/MPH; Gabriel Sekeres, BA; Edward R. Mariano, MD/MAS/FASA; Stavros G. Memtsoudis, MD/PhD/MBA; Eric C. Sun, MD/PhD
Anesthesiology Newly Published on November 1, 2023. doi:https://doi.org/10.1097/ALN.0000000000004827
Perioperative Medicine
Increasing levels of positive end-expiratory pressure cause stepwise biventricular stroke work reduction in a porcine model
Anesthesiology Newly Published on October 31, 2023. doi:https://doi.org/10.1097/ALN.0000000000004821
Perioperative Medicine
Target controlled infusion of remimazolam in healthy volunteers shows some acute tolerance
Remco Vellinga, M.D.; Jeroen V. Koomen, Ph.D.; Douglas J. Eleveld, Ph.D. d; Thomas Stöhr, Ph.D.; Marija Pesic, Ph.D.; Michel M.R.F. Struys, M.D, Ph.D., FRCA; Pieter J. Colin, Ph.D.
Anesthesiology Newly Published on October 27, 2023. doi:https://doi.org/10.1097/ALN.0000000000004811
Perioperative Medicine
Baseline gastric volume of fasting diabetic patients is not higher than that of non-diabetics. A cross-sectional non-inferiority study
Anahi Perlas, MD, FRCPC; Maggie ZX Xiao, BSc; George Tomlinson, PhD; Binu Jacob, PhD; Sara Abdullah, MD; Richelle Kruisselbrink, MD, FRCPC; Vincent WS Chan, MD, FRCPC
Anesthesiology Newly Published on October 26, 2023. doi:https://doi.org/10.1097/ALN.0000000000004815
Perioperative Medicine
Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study
Michael F. Aziz, MD; Katie Schenning, MD; Seiji Koike, M.A.S.; Avital O’Glasser, MD; Vikas N. O’Reilly-Shah, MD, PhD, FASA; Valerie Sera, MD; Michael Mathis, MD
Anesthesiology Newly Published on October 16, 2023. doi:https://doi.org/10.1097/ALN.0000000000004809
Perioperative Medicine
Long-term outcomes with spinal versus general anesthesia for hip fracture surgery: A randomized trial
Emily A. Vail, MD MSc.; Rui Feng, PhD; Frederick Sieber, MD; Jeffrey L. Carson, MD; Susan S. Ellenberg, PhD; Jay Magaziner, PhD MSHyg; Derek Dillane, MD; Edward R. Marcantonio, MD; Daniel I. Sessler, MD; Sabry Ayad, MD; Trevor Stone, MD; Steven Papp, MD; Derek Donegan; Samir Mehta; Eric S. Schwenk, MD; Mitchell Marshall, MD; J. Douglas Jaffe, DO; Charles Luke, MD; Balram Sharma, MD; Syed Azim, MD; Robert Hymes, MD; Ki-Jinn Chin, MD; Richard Sheppard, MD; Barry Perlman, PhD MD; Joshua Sappenfield; Ellen Hauck, DO PhD; Ann Tierney, MS; Annamarie D. Horan, PhD; Mark D. Neuman, MD MSc.; for the REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) Investigators
Anesthesiology Newly Published on October 13, 2023. doi:https://doi.org/10.1097/ALN.0000000000004807
Perioperative Medicine
Development of post-anesthesia care unit delirium is associated with differences in aperiodic and periodic alpha parameters of the EEG during emergence from general anesthesia – results from a prospective observational cohort study
Julian Ostertag, M.Sc.; Antonia Engelhard, B.Sc.; Rachel Nuttall, Ph.D.; Duygu Aydin, B.Sc.; Gerhard Schneider, Prof.; Paul S. García, Ph.D.; Dominik Hinzmann, M.D.; Jamie W. Sleigh, Prof.; Stephan Kratzer, M.D.; Matthias Kreuzer, Ph.D.
Anesthesiology Newly Published on October 10, 2023. doi:https://doi.org/10.1097/ALN.0000000000004797
Perioperative Medicine
Medial Septal Glutamatergic Neurons Modulate States of Consciousness during Sevoflurane Anesthesia in Mice
Jun-Ming Xia, M.D.; Bing-Qian Fan, M.D., Ph.D.; Xiu-Wen Yi, M.D.; Wen-Wen Ni, M.D.; Yu Zhou, M.D.; Dan-Dan Chen, M.D.; Wen-Jing Yi, M.D.; Li-Li Feng, M.N.; Ying Xia, B.N.; Shuang-Shuang Li, M.D., Ph.D.; Wei-Min Qu, M.D., Ph.D.; Yuan Han, M.D., Ph.D.; Zhi-Li Huang, M.D., Ph.D.; Wen-Xian Li, M.D., Ph.D.
Anesthesiology Newly Published on October 9, 2023. doi:https://doi.org/10.1097/ALN.0000000000004798
Perioperative Medicine
Effect of propofol on heart rate and its coupling to cortical slow waves in humans
Anesthesiology Newly Published on October 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004795
Perioperative Medicine
Evaluation of malignant hyperthermia features in patients with pathogenic or likely pathogenic RYR1 variants disclosedthrough a population genomic screening program
Kristen D. Yu, M.S.; Megan N. Betts, M.S.; Gretchen M. Urban, M.S.; Marci L.B. Schwartz, Sc.M.; Tanisha O. Robinson, M.D.; Robert J. Moyer, M.D.; Scott W. Taddonio, D.O.; Anasuya Vasudevan, M.D.; Alicia Johns, Ph.D.; Amy C. Sturm, M.S.; Melissa A. Kelly, M.S.; Marc S. Williams, M.D.; S. Mark Poler, M.D.; Adam H. Buchanan, M.S., M.P.H.
Anesthesiology Newly Published on October 3, 2023. doi:https://doi.org/10.1097/ALN.0000000000004786
Critical Care Medicine
Monitoring of argatroban in critically ill patients: a prospective study comparing aPTT, point-of-care viscoelastic testing with ecarin clotting time and dTT to mass spectrometry
Lars Heubner, MD; Reinhard Oertel, PhD; Oliver Tiebel, MD; Nicole Mehlig-Warnecke; Jan Beyer-Westendorf, MD, PhD; Martin Roessler, PhD; Bertold Renner, MD; Peter Markus Spieth, MD, MSc
Anesthesiology Newly Published on October 3, 2023. doi:https://doi.org/10.1097/ALN.0000000000004787
Perioperative Medicine
Hypoxemia in School Age Children Undergoing One-Lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group (MPOG)
T. Wesley Templeton, M.D.; Bridget Krol, B.A.; Scott Miller, M.D.; Lisa K Lee, M.D. M.S.; Michael R. Mathis, M.D.; Susan R Vishneski, M.D.; Debnath Chatterjee, M.D. F.A.A.P.; Ruchika Gupta, MD; Rebecca A. Shroeder, M.D.; Amit K Saha, Ph.D.; for the Multicenter Perioperative Outcomes Group Investigators
Anesthesiology Newly Published on September 22, 2023. doi:https://doi.org/10.1097/ALN.0000000000004781
Pain Medicine
Opposing effects on descending control of nociception by mu and kappa opioid receptors in the anterior cingulate cortex
Edita Navratilova, Ph.D.; Chaoling Qu, Ph.D.; Guangchen Ji, Ph.D.; Volker Neugebauer, M.D.; Miguel Guerrero, Ph.D.; Hugh Rosen, Ph.D.; Ed Roberts, Ph.D.; Frank Porreca, Ph.D.
Anesthesiology Newly Published on September 19, 2023. doi:https://doi.org/10.1097/ALN.0000000000004773
Perioperative Medicine
One-year outcomes after discharge from noncardiac surgery and association between pre-discharge complications and death after discharge: analysis of the VISION prospective cohort study.
Pavel S. Roshanov; Matthew T.V. Chan; Flavia K. Borges; David Conen; C.Y. Wang; Denis Xavier; Otavio Berwanger; Maura Marcucci; Daniel I. Sessler; Wojciech Szczeklik; Jessica Spence; Pablo Alonso-Coello; Carmen Fernández; Rupert M. Pearse; German Malaga; Amit X. Garg; Sadeesh K. Srinathan; Michael J. Jacka; Vikas Tandon; Michael McGillion; Ekaterine Popova; Alben Sigamani; Valsa Abraham; Bruce M. Biccard; Juan Carlos Villar; Clara K. Chow; Carísi A. Polanczyk; Maria Tiboni; Richard Whitlock; Gareth L. Ackland; Mohamed Panju; André Lamy; Robert Sapsford; Colin Williams; William Ka Kei Wu; Olga L. Cortés; S. Danielle MacNeil; Ameen Patel; Emilie P. Belley-Côté; Sandra Ofori; William F. McIntyre; Darryl P. Leong; Diane Heels-Ansdell; Krysten Gregus; P.J. Devereaux
Anesthesiology Newly Published on September 15, 2023. doi:https://doi.org/10.1097/ALN.0000000000004763
Critical Care Medicine
The causes of hypoxemia of COVID-19 ARDS: a combined MIGET and Dual-Energy CT study
Mattia Busana, MD; Anna Rau, MD; Stefano Lazzari, MD; Simone Gattarello, MD; Massimo Cressoni, MD; Lorenz Biggemann, MD; Lars-Olav Harnisch, MD; Lorenzo Giosa, MD; Andreas Vogt, MD; Leif Saager, MD; Joachim Lotz, MD; Birgit Meller, MD; Konrad Meissner, MD; Luciano Gattinoni, MD; Onnen Moerer, MD
Anesthesiology Newly Published on September 1, 2023. doi:https://doi.org/10.1097/ALN.0000000000004757
Publish Ahead of Print
Perioperative Medicine
Cerebral Blood Flow Assessed with Phase-contrast Magnetic Resonance Imaging during Blood Pressure Changes with Noradrenaline and Labetalol: A Trial in Healthy Volunteers
Johan Birnefeld, M.D.; Karl Petersson, M.D.; Anders Wåhlin, Ph.D.; Anders Eklund, Ph.D.; Elin Birnefeld, M.D.; Sara Qvarlander, Ph.D.; Michael Haney, M.D., Ph.D.; Jan Malm, M.D., Ph.D.; Laleh Zarrinkoob, M.D., Ph.D.
Anesthesiology Newly Published on November 20, 2023. doi:https://doi.org/10.1097/ALN.0000000000004775
Correspondence
ASA Consensus-based Guidance on Preoperative Management of Patients on Glucagon-like Peptide-1 Receptor Agonists
Deepu S. Ushakumari, M.B.B.S., M.H.C.D.S., D.F.P.M., F.A.S.A., F.A.C.H.E., C.P.E.; Robert N. Sladen, M.B.Ch.B., M.R.C.P.(UK), F.R.C.P.C., F.C.C.M.
Anesthesiology Newly Published on November 20, 2023. doi:https://doi.org/10.1097/ALN.0000000000004776
Mind to Mind
New Prescription
Anesthesiology Newly Published on November 20, 2023. doi:https://doi.org/10.1097/ALN.0000000000004778
Clinical Focus Review
Damage Control Resuscitation in Traumatic Hemorrhage: It is More Than Fixing the Holes and Filling the Tank
Anesthesiology Newly Published on November 20, 2023. doi:https://doi.org/10.1097/ALN.0000000000004750
Perioperative Medicine
Intraoperative Use of Phenylephrine versus Ephedrine and Postoperative Delirium: A Multicenter Retrospective Cohort Study
Haobo Ma, M.D., M.Sc.; Elena Ahrens, cand. med.; Luca J. Wachtendorf, cand. med.; Aiman Suleiman, M.D., M.Sc.; Denys Shay, M.D.; Ricardo Munoz-Acuna, M.D.; Tim M. Tartler, M.D.; Bijan Teja, M.D., M.B.A.; Soeren Wagner, M.D.; Balachundhar Subramaniam, M.D., M.P.H.; James Rhee, M.D., Ph.D.; Maximilian S. Schaefer, M.D., Ph.D.
Anesthesiology Newly Published on November 15, 2023. doi:https://doi.org/10.1097/ALN.0000000000004774
Correspondence
Too Good to Be True?
Anesthesiology Newly Published on November 15, 2023. doi:https://doi.org/10.1097/ALN.0000000000004736
Perioperative Medicine
Prediction of Complications and Prognostication in Perioperative Medicine: A Systematic Review and PROBAST Assessment of Machine Learning Tools
Pietro Arina, M.D.; Maciej R. Kaczorek, B.E.; Daniel A. Hofmaenner, M.D.; Walter Pisciotta, M.D.; Patricia Refinetti, M.D.; Mervyn Singer, F.R.C.P.; Evangelos B. Mazomenos, Ph.D.; John Whittle, M.D.
Anesthesiology Newly Published on November 9, 2023. doi:https://doi.org/10.1097/ALN.0000000000004764
Pain Medicine
Impaired Lactate Release in Dorsal CA1 Astrocytes Contributed to Nociceptive Sensitization and Comorbid Memory Deficits in Rodents
Shuang Han, B.S.; Bin Jiang, Ph.D.; Jiale Ren, B.S.; Feng Gao, M.S.; Junjian Wen, M.S.; Taihe Zhou, B.S.; Laijian Wang, Ph.D.; Xuhong Wei, M.D.
Anesthesiology Newly Published on November 7, 2023. doi:https://doi.org/10.1097/ALN.0000000000004756
Correspondence
Trust the Gold Standard: All Glucagon-like Peptide-1 Receptor Agonists Can Delay Gastric Emptying
Anesthesiology Newly Published on November 7, 2023. doi:https://doi.org/10.1097/ALN.0000000000004752
Critical Care Medicine
Combining the Physical–Chemical Approach with Standard Base Excess to Understand the Compensation of Respiratory Acid–Base Derangements: An Individual Participant Meta-analysis Approach to Data from Multiple Canine and Human Experiments
Francesco Zadek, M.D.; Andrea Danieli, M.D.; Serena Brusatori, M.D.; Lorenzo Giosa, M.D.; Martin Krbec, M.D.; Laura Antolini, Ph.D.; Roberto Fumagalli, M.D.; Thomas Langer, M.D.
Anesthesiology Newly Published on November 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004751
Perioperative Medicine
U.S. Attending Anesthesiologist Burnout in the Postpandemic Era
Anoushka M. Afonso, M.D.; Joshua B. Cadwell, M.D., M.B.A.; Steven J. Staffa, M.S.; Jina L. Sinskey, M.D.; Amy E. Vinson, M.D.
Anesthesiology Newly Published on November 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004784
Reviews of Educational Material
Say Anarcha: A Young Woman, A Devious Surgeon, and the Harrowing Birth of Modern Women’s Health
Anesthesiology Newly Published on November 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004771
Mind to Mind
The Human Connection
Anesthesiology Newly Published on November 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004749
Images in Anesthesiology
Hematoma with Airway Compromise after Thyroidectomy
Anesthesiology Newly Published on November 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004718
Correspondence
Prolonged Opioid Use and Pain after Surgery: Comment
Anesthesiology Newly Published on October 31, 2023. doi:https://doi.org/10.1097/ALN.0000000000004727
Correspondence
Prolonged Opioid Use and Pain after Surgery: Reply
Kai Kuck, Ph.D.; Nathan L. Pace, M.D., M.Stat.; Bhiken I. Naik, M.B.B.Ch., M.S.C.R.; Karen B. Domino, M.D., M.P.H.; Karen L. Posner, Ph.D.; Leif Saager, M.D.
Anesthesiology Newly Published on October 31, 2023. doi:https://doi.org/10.1097/ALN.0000000000004728
Correspondence
Prolonged Opioid Use and Pain after Surgery: Comment
Anesthesiology Newly Published on October 31, 2023. doi:https://doi.org/10.1097/ALN.0000000000004726
Mind to Mind
The Walk
Anesthesiology Newly Published on October 23, 2023. doi:https://doi.org/10.1097/ALN.0000000000004740
Critical Care Medicine
Diaphragm Dysfunction Predicts Weaning Outcome after Bilateral Lung Transplant
Annalisa Boscolo, M.D., Ph.D.; Nicolò Sella, M.D.; Tommaso Pettenuzzo, M.D.; Elisa Pistollato, M.D.; Fiorella Calabrese, M.D.; Dario Gregori, Ph.D.; Gianmaria Cammarota, M.D.; Martin Dres, M.D.; Federico Rea, M.D.; Paolo Navalesi, M.D., F.E.R.S.; Padua-Lung Transplant Group
Anesthesiology Newly Published on October 9, 2023. doi:https://doi.org/10.1097/ALN.0000000000004729
Clinical Focus Review
Meaning and Management of Perioperative Oliguria
Roberta Teixeira Tallarico, M.D.; Ian E. McCoy, M.D., M.S.; Francois Dépret, M.D., Ph.D.; Matthieu Legrand, M.D., Ph.D.
Anesthesiology Newly Published on October 9, 2023. doi:https://doi.org/10.1097/ALN.0000000000004746
Mind to Mind
Extracorporeal
Anesthesiology Newly Published on October 6, 2023. doi:https://doi.org/10.1097/ALN.0000000000004732
Correspondence
Laser-assisted Pediatric Radial Artery Cannulation: Comment
Anesthesiology Newly Published on September 26, 2023. doi:https://doi.org/10.1097/ALN.0000000000004723
Correspondence
Laser-assisted Pediatric Radial Artery Cannulation: Reply
Anesthesiology Newly Published on September 26, 2023. doi:https://doi.org/10.1097/ALN.0000000000004724
Clinical Focus Review
Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology
Anesthesiology Newly Published on August 31, 2023. doi:https://doi.org/10.1097/ALN.0000000000004686
Clinical Focus Review
What’s in Your Transfusion? A Bedside Guide to Blood Products and Their Preparation
Anesthesiology Newly Published on August 28, 2023. doi:https://doi.org/10.1097/ALN.0000000000004655
Mind to Mind
Treading Through Twilight
Anesthesiology Newly Published on August 23, 2023. doi:https://doi.org/10.1097/ALN.0000000000004661
Mind to Mind
Decels: An Obstetric Anesthesiology Adaptation of Edgar Allan Poe’s “The Bells”
Anesthesiology Newly Published on July 4, 2023. doi:https://doi.org/10.1097/ALN.0000000000004636
Correspondence
Population Volume Kinetics in Volunteers: Comment
Anesthesiology Newly Published on February 20, 2020. doi:https://doi.org/10.1097/ALN.0000000000003210
Correspondence
Population Volume Kinetics in Volunteers: Reply
Anesthesiology Newly Published on February 20, 2020. doi:https://doi.org/10.1097/ALN.0000000000003211
