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Volume 129, Issue 4

October 2018

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In this Issue

Table of Contents
Editorial Board
This Month in Anesthesiology
Science, Medicine, and the Anesthesiologist
Infographics in Anesthesiology
Anesthesiology CME Program
Editorial
Special Announcements
Perioperative Medicine: Clinical Science
Perioperative Medicine: Basic Science
Critical Care Medicine: Clinical Science
Pain Medicine: Basic Science
Education: Images in Anesthesiology
Education: Original Investigations in Education
Education: Review Article
Education: Mind to Mind
Correspondence
Reviews of Educational Material
Anesthesiology Reflections from the Wood Library-Museum
Erratum

Anesthesiology

Anesthesiology October 2018, Vol. 129, A7–A15. https://doi.org/10.1097/ALN.0000000000002459

View Articletitled, Anesthesiology

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Editorial Board

Anesthesiology

Anesthesiology October 2018, Vol. 129, A21–A22. https://doi.org/10.1097/ALN.0000000000002442

View Articletitled, Anesthesiology

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This Month in Anesthesiology

Anesthesiology October 2018, Vol. 129, A1–A2. https://doi.org/10.1097/ALN.0000000000002441

View Articletitled, This Month in Anesthesiology

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Science, Medicine, and the Anesthesiologist

Anesthesiology October 2018, Vol. 129, A25–A28. https://doi.org/10.1097/ALN.0000000000002443

View Articletitled, Science, Medicine, and the Anesthesiologist

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Infographics in Anesthesiology

Machine Learning for Anesthesiologists: A Primer

Jonathan P. Wanderer; James P. Rathmell

Anesthesiology October 2018, Vol. 129, A29. https://doi.org/10.1097/ALN.0000000000002444

View Articletitled, Machine Learning for Anesthesiologists: A Primer

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Topics: machine learning

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

Anesthesiology October 2018, Vol. 129, A23. https://doi.org/10.1097/ALN.0000000000002427

View Articletitled, Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

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Editorial

Artificial Intelligence for Anesthesia: What the Practicing Clinician Needs to Know: More than Black Magic for the Art of the Dark

Michael R. Mathis, M.D.; Sachin Kheterpal, M.D., M.B.A.; Kayvan Najarian, Ph.D.

Anesthesiology October 2018, Vol. 129, 619–622. https://doi.org/10.1097/ALN.0000000000002384

View Articletitled, Artificial Intelligence for Anesthesia: What the Practicing Clinician Needs to Know: More than Black Magic for the Art of the Dark

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Topics: artificial intelligence , machine learning

Liposomal Bupivacaine Infiltration for Knee Arthroplasty: Significant Analgesic Benefits or Just a Bunch of Fat?

Brian M. Ilfeld, M.D., M.S.; Rodney A. Gabriel, M.D., M.A.S.; James C. Eisenach, M.D.

Anesthesiology October 2018, Vol. 129, 623–626. https://doi.org/10.1097/ALN.0000000000002386

View Articletitled, Liposomal Bupivacaine Infiltration for Knee Arthroplasty: Significant Analgesic Benefits or Just a Bunch of Fat?

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Topics: analgesics , bupivacaine , knee replacement arthroplasty , liposomes

New Worlds to Conquer

Richard P. Dutton, M.D., M.B.A., F.A.S.A.

Anesthesiology October 2018, Vol. 129, 627–628. https://doi.org/10.1097/ALN.0000000000002330

View Articletitled, New Worlds to Conquer

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Topics: inpatients , mortality , perioperative care , surgical procedures, operative , length of stay

Flashes of Insight: Applying New Techniques to a Classic Model

Andrew E. Hudson, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 629–630. https://doi.org/10.1097/ALN.0000000000002388

View Articletitled, Flashes of Insight: Applying New Techniques to a Classic Model

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Topics: photopsia , neurons

Maintenance of Certification: Has MOC Gone Amok?

Mark Nelson, M.D.; John F. Butterworth, IV, M.D.

Anesthesiology October 2018, Vol. 129, 631–633. https://doi.org/10.1097/ALN.0000000000002387

View Articletitled, Maintenance of Certification: Has MOC Gone Amok?

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Topics: amok , maintenance of certification , adult

Special Announcements

Journal-related Activities and Other Special Activities at the 2018 American Society of Anesthesiologists Meeting

Michael J. Avram, Ph.D.; J. David Clark, M.D., Ph.D.; Andrew Davidson, M.B.B.S., M.D., F.A.N.Z.C.A.; Evan D. Kharasch, M.D., Ph.D.; Sachin Kheterpal, M.D., M.B.A.; Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M.

Anesthesiology October 2018, Vol. 129, 634–643. https://doi.org/10.1097/ALN.0000000000002404

View Articletitled, Journal-related Activities and Other Special Activities at the 2018 American Society of Anesthesiologists Meeting

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Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., Recipient of the 2018 Excellence in Research Award

Alex S. Evers, M.D.

Anesthesiology October 2018, Vol. 129, 644–645. https://doi.org/10.1097/ALN.0000000000002380

View Articletitled, Beverley A. Orser, M.D., Ph.D., F.R.C.P.C., F.C.A.H.S., Recipient of the 2018 Excellence in Research Award

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Brian Bateman, M.D., Recipient of the 2018 James E. Cottrell, M.D., Presidential Scholar Award

James P. Rathmell, M.D.

Anesthesiology October 2018, Vol. 129, 646–648. https://doi.org/10.1097/ALN.0000000000002377

View Articletitled, Brian Bateman, M.D., Recipient of the 2018 James E. Cottrell, M.D., Presidential Scholar Award

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Perioperative Medicine: Clinical Science

Development and Validation of a Deep Neural Network Model for Prediction of Postoperative In-hospital Mortality

Christine K. Lee, M.S., Ph.D.; Ira Hofer, M.D.; Eilon Gabel, M.D.; Pierre Baldi, Ph.D.; Maxime Cannesson, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 649–662. https://doi.org/10.1097/ALN.0000000000002186

View Articletitled, Development and Validation of a Deep Neural Network Model for Prediction of Postoperative In-hospital Mortality

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Topics: hospital mortality , mortality , preoperative care , surgical procedures, operative , calibration

Machine-learning Algorithm to Predict Hypotension Based on High-fidelity Arterial Pressure Waveform Analysis

Feras Hatib, Ph.D.; Zhongping Jian, Ph.D.; Sai Buddi, Ph.D.; Christine Lee, M.S.; Jos Settels, M.S.; Karen Sibert, M.D., F.A.S.A.; Joseph Rinehart, M.D.; Maxime Cannesson, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 663–674. https://doi.org/10.1097/ALN.0000000000002300

View Articletitled, Machine-learning Algorithm to Predict Hypotension Based on High-fidelity Arterial Pressure Waveform Analysis

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Topics: arterial pressure , hypotension , machine learning , waveforms , datasets

Supervised Machine-learning Predictive Analytics for Prediction of Postinduction Hypotension

Samir Kendale, M.D.; Prathamesh Kulkarni, Ph.D.; Andrew D. Rosenberg, M.D.; Jing Wang, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 675–688. https://doi.org/10.1097/ALN.0000000000002374

View Articletitled, Supervised Machine-learning Predictive Analytics for Prediction of Postinduction Hypotension

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Topics: hypotension , machine learning , roc curve

Liposomal Bupivacaine Does Not Reduce Inpatient Opioid Prescription or Related Complications after Knee Arthroplasty: A Database Analysis

Lukas Pichler, M.D.; Jashvant Poeran, M.D., Ph.D.; Nicole Zubizarreta, M.P.H.; Crispiana Cozowicz, M.D.; Eric C. Sun, M.D., Ph.D.; Madhu Mazumdar, Ph.D.; Stavros G. Memtsoudis, M.D., Ph.D., F.C.C.P.

Anesthesiology October 2018, Vol. 129, 689–699. https://doi.org/10.1097/ALN.0000000000002267

View Articletitled, Liposomal Bupivacaine Does Not Reduce Inpatient Opioid Prescription or Related Complications after Knee Arthroplasty: A Database Analysis

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Topics: bupivacaine , inpatients , knee replacement arthroplasty , liposomes , opioid analgesics

Anesthesia Care Team Composition and Surgical Outcomes

Eric C. Sun, M.D., Ph.D.; Thomas R. Miller, Ph.D., M.B.A.; Jasmin Moshfegh, M.A., M.Sc.; Laurence C. Baker, Ph.D.

Anesthesiology October 2018, Vol. 129, 700–709. https://doi.org/10.1097/ALN.0000000000002275

View Articletitled, Anesthesia Care Team Composition and Surgical Outcomes

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Topics: anesthesia care , inpatients , nurse anesthetists , surgical outcome , surgical procedures, operative

Preoperative Epoetin-α with Intravenous or Oral Iron for Major Orthopedic Surgery: A Randomized Controlled Trial

Philippe Biboulet, M.D.; Sophie Bringuier, Pharm.D., Ph.D.; Pierre Smilevitch, M.D.; Thibault Loupec, M.D.; Caroline Thuile, M.D.; Mathieu Pencole, M.D.; Guillaume Maissiat, M.D.; Gaëtan Dangelser, M.D.; Xavier Capdevila, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 710–720. https://doi.org/10.1097/ALN.0000000000002376

View Articletitled, Preoperative Epoetin-α with Intravenous or Oral Iron for Major Orthopedic Surgery: A Randomized Controlled Trial

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Topics: erythropoietin , hemoglobin , iron , orthopedic procedures , orthopedics

Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network

Benjamin J. Walker, M.D.; Justin B. Long, M.D.; Madhankumar Sathyamoorthy, M.B.B.S., M.S., M.B.A.; Jennifer Birstler, M.S.; Christine Wolf, M.B.S.; Adrian T. Bosenberg, M.B., Ch.B., F.F.A. (S.A.); Sean H. Flack, M.B., Ch.B., F.C.A.; Elliot J. Krane, M.D., F.A.A.P.; Navil F. Sethna, M.D.; Santhanam Suresh, M.D., F.A.A.P.; Andreas H. Taenzer, M.S., M.D.; David M. Polaner, M.D., F.A.A.P.; on behalf of the Pediatric Regional Anesthesia Network Investigators

Anesthesiology October 2018, Vol. 129, 721–732. https://doi.org/10.1097/ALN.0000000000002372

View Articletitled, Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network

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Topics: catheters , child , hospitals, pediatric , local anesthetic agent overdose , pediatric regional anesthesia

Perioperative Medicine: Basic Science

Breakdown of Neural Function under Isoflurane Anesthesia: In Vivo, Multineuronal Imaging in Caenorhabditis elegans

Mehraj R. Awal, B.S.; Doug Austin, B.A.; Jeremy Florman, B.A.; Mark Alkema, Ph.D.; Christopher V. Gabel, Ph.D.; Christopher W. Connor, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 733–743. https://doi.org/10.1097/ALN.0000000000002342

View Articletitled, Breakdown of Neural Function under Isoflurane Anesthesia: In Vivo, Multineuronal Imaging in Caenorhabditis elegans

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Topics: caenorhabditis elegans , diagnostic imaging , isoflurane , neurons , neurophysiology-biologic function

Anesthetics Have Different Effects on the Electrocorticographic Spectra of Wild-type and Mitochondrial Mutant Mice

Charles William Carspecken, M.D.; Sirisak Chanprasert, M.D.; Franck Kalume, Ph.D.; Margaret M. Sedensky, M.D.; Philip G. Morgan, M.D.

Anesthesiology October 2018, Vol. 129, 744–755. https://doi.org/10.1097/ALN.0000000000002368

View Articletitled, Anesthetics Have Different Effects on the Electrocorticographic Spectra of Wild-type and Mitochondrial Mutant Mice

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Topics: electrocorticogram , genotype , ketamine , mice , mitochondria

Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase

Pan-Fen Wang, Ph.D.; Alicia Neiner; Evan D. Kharasch, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 756–768. https://doi.org/10.1097/ALN.0000000000002371

View Articletitled, Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase

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Topics: cyp2b6 gene , cytochrome p450 , cytochrome p450 cyp2b6 enzyme , ketamine , metabolism

Critical Care Medicine: Clinical Science

Standardized Unloading of Respiratory Muscles during Neurally Adjusted Ventilatory Assist: A Randomized Crossover Pilot Study

Francesca Campoccia Jalde, M.D., Ph.D.; Fredrik Jalde, M.Sc.; Mats K. E. B. Wallin, M.Sc., M.D., Ph.D.; Fernando Suarez-Sipmann, M.D., Ph.D.; Peter J. Radell, M.D., Ph.D.; David Nelson, M.D., Ph.D.; Staffan Eksborg, M.D., Ph.D.; Peter V. Sackey, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 769–777. https://doi.org/10.1097/ALN.0000000000002335

View Articletitled, Standardized Unloading of Respiratory Muscles during Neurally Adjusted Ventilatory Assist: A Randomized Crossover Pilot Study

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Topics: neurally adjusted ventilatory assist , respiration , respiratory muscles

Pain Medicine: Basic Science

Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats

Douglas G. Ririe, M.D., Ph.D.; M. Danilo Boada, M.D.; Megan K. MacGregor, B.S.; Salem J. Martin, B.A.; Tracy J. Strassburg, B.A.; Susy A. Kim, B.A.; James C. Eisenach, M.D.; Thomas J. Martin, Ph.D.

Anesthesiology October 2018, Vol. 129, 778–790. https://doi.org/10.1097/ALN.0000000000002325

View Articletitled, Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats

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Topics: prefrontal cortex , rats , reaction time , surgical procedures, operative , titration method

Effect of Thoracic Epidural Anesthesia in a Rat Model of Phrenic Motor Inhibition after Upper Abdominal Surgery

Won-Seok Chae, M.D.; Soron Choi, M.D., Ph.D.; Daisuke Sugiyama, M.D., Ph.D.; George B. Richerson, M.D., Ph.D.; Timothy J. Brennan, M.D., Ph.D.; Sinyoung Kang, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 791–807. https://doi.org/10.1097/ALN.0000000000002331

View Articletitled, Effect of Thoracic Epidural Anesthesia in a Rat Model of Phrenic Motor Inhibition after Upper Abdominal Surgery

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Topics: abdomen incision , abdominal surgery , bupivacaine , local anesthetic thoracic epidural block , phrenic nerve

Education: Images in Anesthesiology

Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema

Sheri Jones, M.D.; Shanique Kilgallon, M.D.; Alan Jay Schwartz, M.D., M.S.Ed.; Rajeev Subramanyam, M.D., M.S.

Anesthesiology October 2018, Vol. 129, 808. https://doi.org/10.1097/ALN.0000000000002251

View Articletitled, Images in Anesthesiology: Persistent Pulmonary Interstitial Emphysema

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Topics: interstitial emphysema of lung , persistence

Delayed Tension Pneumomediastinum after Cardiac Surgery

Michael W. Wolfe, M.D.; Joseph S. Meltzer, M.D.

Anesthesiology October 2018, Vol. 129, 809. https://doi.org/10.1097/ALN.0000000000002257

View Articletitled, Delayed Tension Pneumomediastinum after Cardiac Surgery

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Topics: cardiac surgery procedures , mediastinal emphysema

Reinke’s Edema: Implications for Airway Management

Roshni Sreedharan, M.D.; Surendrasingh Chhabada, M.D., F.A.A.P.; Sandeep Khanna, M.D.

Anesthesiology October 2018, Vol. 129, 810. https://doi.org/10.1097/ALN.0000000000002259

View Articletitled, Reinke’s Edema: Implications for Airway Management

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Topics: airway maintenance , reinke's edema

Saber-sheath Tracheal Deformity

Ali Kandil, D.O., M.P.H.; Arpa Chutipongtanate, M.D.; Robert E. Wood, Ph.D., M.D.; Mohamed Mahmoud, M.D.

Anesthesiology October 2018, Vol. 129, 811. https://doi.org/10.1097/ALN.0000000000002268

View Articletitled, Saber-sheath Tracheal Deformity

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Topics: trachea

Education: Original Investigations in Education

Association between Performance in a Maintenance of Certification Program and Disciplinary Actions against the Medical Licenses of Anesthesiologists

Yan Zhou, Ph.D.; Huaping Sun, Ph.D.; Alex Macario, M.D., M.B.A.; Mark T. Keegan, M.B., B.Ch.; Andrew J. Patterson, M.D., Ph.D.; Mohammed M. Minhaj, M.D., M.B.A.; Ting Wang, Ph.D.; Ann E. Harman, Ph.D.; David O. Warner, M.D.

Anesthesiology October 2018, Vol. 129, 812–820. https://doi.org/10.1097/ALN.0000000000002326

View Articletitled, Association between Performance in a Maintenance of Certification Program and Disciplinary Actions against the Medical Licenses of Anesthesiologists

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Topics: licensure , maintenance of certification

Reducing the Incidence of Substance Use Disorders in Anesthesiology Residents: 13 Years of Comprehensive Urine Drug Screening

Michael G. Fitzsimons, M.D.; Keith Baker, M.D., Ph.D.; Rajeev Malhotra, M.D.; Andrew Gottlieb, N.P.; Edward Lowenstein, M.D.; Warren M. Zapol, M.D.

Anesthesiology October 2018, Vol. 129, 821–828. https://doi.org/10.1097/ALN.0000000000002348

View Articletitled, Reducing the Incidence of Substance Use Disorders in Anesthesiology Residents: 13 Years of Comprehensive Urine Drug Screening

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Topics: internship and residency , medical residencies , substance use disorders , urine drug screening , substance abuse detection

Education: Review Article

Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms

Miles Berger, M.D., Ph.D.; Niccolò Terrando, Ph.D.; S. Kendall Smith, M.D., Ph.D.; Jeffrey N. Browndyke, Ph.D.; Mark F. Newman, M.D.; Joseph P. Mathew, M.D., M.H.Sc., M.B.A.

Anesthesiology October 2018, Vol. 129, 829–851. https://doi.org/10.1097/ALN.0000000000002194

View Articletitled, Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms

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Topics: cardiac surgery procedures , postoperative cognitive dysfunction , delirium , postoperative delirium , cognitive impairment

Education: Mind to Mind

Vanishing Point

Maxine Susman

Anesthesiology October 2018, Vol. 129, 852. https://doi.org/10.1097/ALN.0000000000002260

View Articletitled, Vanishing Point

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Topics: acmesthesia , blizzards , cold sensation , cold temperature , color

Preanesthesia Premedication: The “Monaldi” Protocol

Marco Rispoli, M.D.; Antonio Bevilacqua, B.S.N.; Giuseppe De Falco, B.S.N.; Danilo Esposito, B.S.N.; Salvatore Matrullo, B.S.N.

Anesthesiology October 2018, Vol. 129, 853–854. https://doi.org/10.1097/ALN.0000000000002319

View Articletitled, Preanesthesia Premedication: The “Monaldi” Protocol

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Topics: preanesthetic medication , premedication

Correspondence

Questions about the Practice Management Guidelines for Moderate Sedation and Analgesia

Davide Cattano, M.D., Ph.D.

Anesthesiology October 2018, Vol. 129, 855. https://doi.org/10.1097/ALN.0000000000002405

View Articletitled, Questions about the Practice Management Guidelines for Moderate Sedation and Analgesia

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In Reply

Jeffrey L. Apfelbaum, M.D.; Richard T. Connis, Ph.D.

Anesthesiology October 2018, Vol. 129, 855–856. https://doi.org/10.1097/ALN.0000000000002406

View Articletitled, In Reply

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Reviews of Educational Material

Quick Draw Anatomy for Anaesthetists.

James P. Rathmell, M.D.

Anesthesiology October 2018, Vol. 129, 857–858. https://doi.org/10.1097/ALN.0000000000002344

View Articletitled, Quick Draw Anatomy for Anaesthetists.

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Topics: abdomen , airway device , airway structure , book reviews , brachial plexus

Anesthesiology Reflections from the Wood Library-Museum

From Horse to Hearse: Tragedy Strikes Laughing-gas Dentist Charles Henry Neall

Anesthesiology October 2018, Vol. 129, 622. https://doi.org/10.1097/ALN.0000000000002445

View Articletitled, From Horse to Hearse: Tragedy Strikes Laughing-gas Dentist Charles Henry Neall

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How Two Longfellows Revered Ether

Anesthesiology October 2018, Vol. 129, 709. https://doi.org/10.1097/ALN.0000000000002446

View Articletitled, How Two Longfellows Revered Ether

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Birth Centennial of Nobel Laureate Skou, an Investigator of Local Anesthetics and the Sodium–Potassium Pump

Anesthesiology October 2018, Vol. 129, 777. https://doi.org/10.1097/ALN.0000000000002447

View Articletitled, Birth Centennial of Nobel Laureate Skou, an Investigator of Local Anesthetics and the Sodium–Potassium Pump

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Ohmeda Slide Rule for Pressures and Volumes

Anesthesiology October 2018, Vol. 129, 790. https://doi.org/10.1097/ALN.0000000000002448

View Articletitled, Ohmeda Slide Rule for Pressures and Volumes

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From “Bagging” Patients to Bagging Dr. Heidbrink, Maker of Anesthesia Machines

Anesthesiology October 2018, Vol. 129, 820. https://doi.org/10.1097/ALN.0000000000002449

View Articletitled, From “Bagging” Patients to Bagging Dr. Heidbrink, Maker of Anesthesia Machines

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Haunted Anesthesia? Spirited Herbs in Mayo’s Vegetable Vapor

Anesthesiology October 2018, Vol. 129, 828. https://doi.org/10.1097/ALN.0000000000002450

View Articletitled, Haunted Anesthesia? Spirited Herbs in Mayo’s Vegetable Vapor

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Erratum

Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain: Erratum

Anesthesiology October 2018, Vol. 129, 859. https://doi.org/10.1097/ALN.0000000000002383

View Articletitled, Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain: Erratum

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Issues

Cover Image

Table of Contents

Editorial Board

This Month in Anesthesiology

Science, Medicine, and the Anesthesiologist

Infographics in Anesthesiology

Anesthesiology CME Program

Editorial

Special Announcements

Perioperative Medicine: Clinical Science

Perioperative Medicine: Basic Science

Critical Care Medicine: Clinical Science

Pain Medicine: Basic Science

Education: Images in Anesthesiology

Education: Original Investigations in Education

Education: Review Article

Education: Mind to Mind

Correspondence

Reviews of Educational Material

Anesthesiology Reflections from the Wood Library-Museum

Erratum

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