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Volume 129, Issue 2

August 2018

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In this Issue

Table of Contents
Editorial Board
This Month in Anesthesiology
Science, Medicine, and the Anesthesiologist
Infographics in Anesthesiology
Anesthesiology CME Program
Editorial
Perioperative Medicine: Clinical Science
Perioperative Medicine: Basic Science
Critical Care Medicine: Basic Science
Critical Care Medicine: Clinical Science
Education: Classic Papers Revisited
Education: Images in Anesthesiology
Education: Clinical Focus Review
Education: Review Article
Education: Mind to Mind
Correspondence
Anesthesiology Reflections from the Wood Library-Museum
Erratum

Anesthesiology

Anesthesiology August 2018, Vol. 129, A1–A5. https://doi.org/10.1097/ALN.0000000000002378

View Articletitled, Anesthesiology

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Editorial Board

Anesthesiology

Anesthesiology August 2018, Vol. 129, A11–A12. https://doi.org/10.1097/ALN.0000000000002363

View Articletitled, Anesthesiology

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This Month in Anesthesiology

Anesthesiology August 2018, Vol. 129, A3–A4. https://doi.org/10.1097/ALN.0000000000002365

View Articletitled, This Month in Anesthesiology

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Science, Medicine, and the Anesthesiologist

Anesthesiology August 2018, Vol. 129, A14–A17. https://doi.org/10.1097/ALN.0000000000002366

View Articletitled, Science, Medicine, and the Anesthesiologist

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Infographics in Anesthesiology

How Low Can You Go? Minimum Dosage and Safety of Intraneural Sciatic Nerve Blocks

Jonathan P. Wanderer; James P. Rathmell

Anesthesiology August 2018, Vol. 129, A18. https://doi.org/10.1097/ALN.0000000000002364

View Articletitled, How Low Can You Go? Minimum Dosage and Safety of Intraneural Sciatic Nerve Blocks

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Topics: safety , sciatic nerve block

Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

Anesthesiology August 2018, Vol. 129, A13. https://doi.org/10.1097/ALN.0000000000002340

View Articletitled, Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit

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Editorial

Intraneural Injection: Is the Jury Still Out?

Kamen Vlassakov, M.D.; Philipp Lirk, M.D., Ph.D.; James P. Rathmell, M.D.

Anesthesiology August 2018, Vol. 129, 221–224. https://doi.org/10.1097/ALN.0000000000002352

View Articletitled, Intraneural Injection: Is the Jury Still Out?

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Topics: intraneural injections

Dantrolene and Malignant Hyperthermia Carts: Do We Need Them on Maternity Units?

Cynthia A. Wong, M.D.

Anesthesiology August 2018, Vol. 129, 225–227. https://doi.org/10.1097/ALN.0000000000002279

View Articletitled, Dantrolene and Malignant Hyperthermia Carts: Do We Need Them on Maternity Units?

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Topics: dantrolene , malignant hyperthermia due to anesthesia

Anesthetic Action and “Quantum Consciousness”: A Match Made in Olive Oil

Stuart R. Hameroff, M.D.

Anesthesiology August 2018, Vol. 129, 228–231. https://doi.org/10.1097/ALN.0000000000002273

View Articletitled, Anesthetic Action and “Quantum Consciousness”: A Match Made in Olive Oil

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Topics: consciousness related finding , olive oil , brain

Targeting Microglia: A New Avenue for Anesthesia Neuroprotection after Brain Injury?

Laszlo Vutskits, M.D., Ph.D.; Jeffrey W. Sall, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 232–234. https://doi.org/10.1097/ALN.0000000000002272

View Articletitled, Targeting Microglia: A New Avenue for Anesthesia Neuroprotection after Brain Injury?

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Topics: brain injuries , microglia , neuroprotection

Natriuretic Peptides: A Role in Early Septic Acute Kidney Injury?

Nishkantha Arulkumaran, M.B.B.S., B.Sc., Ph.D., M.R.C.P., F.F.I.C.M.; John R. Prowle, M.A., M.B., B.Chir., M.Sc., M.D., F.R.C.P., F.F.I.C.M.

Anesthesiology August 2018, Vol. 129, 235–237. https://doi.org/10.1097/ALN.0000000000002307

View Articletitled, Natriuretic Peptides: A Role in Early Septic Acute Kidney Injury?

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Topics: natriuretic peptides , renal failure, acute

Dying as a Pathway to Death in Sepsis

Wenxiao Zhang, M.D.; Craig M. Coopersmith, M.D.

Anesthesiology August 2018, Vol. 129, 238–240. https://doi.org/10.1097/ALN.0000000000002271

View Articletitled, Dying as a Pathway to Death in Sepsis

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Topics: sepsis

Perioperative Medicine: Clinical Science

Intraneural Ultrasound-guided Sciatic Nerve Block: Minimum Effective Volume and Electrophysiologic Effects

Gianluca Cappelleri, M.D.; Andrea Luigi Ambrosoli, M.D.; Marco Gemma, M.D.; Valeria Libera Eva Cedrati, M.D.; Federico Bizzarri, M.D.; Giorgio Francesco Danelli, M.D.

Anesthesiology August 2018, Vol. 129, 241–248. https://doi.org/10.1097/ALN.0000000000002254

View Articletitled, Intraneural Ultrasound-guided Sciatic Nerve Block: Minimum Effective Volume and Electrophysiologic Effects

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Topics: anesthesia, local , anesthetics, local , ropivacaine , sciatic nerve block , ultrasonography

Cost-benefit Analysis of Maintaining a Fully Stocked Malignant Hyperthermia Cart versus an Initial Dantrolene Treatment Dose for Maternity Units

Phi T. Ho, M.D., M.B.A.; Brendan Carvalho, M.B.B.Ch., F.R.C.A., M.D.C.H.; Eric C. Sun, M.D., Ph.D.; Alex Macario, M.D., M.B.A.; Edward T. Riley, M.D.

Anesthesiology August 2018, Vol. 129, 249–259. https://doi.org/10.1097/ALN.0000000000002231

View Articletitled, Cost-benefit Analysis of Maintaining a Fully Stocked Malignant Hyperthermia Cart versus an Initial Dantrolene Treatment Dose for Maternity Units

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Topics: cost-benefit analysis , dantrolene , malignant hyperthermia due to anesthesia , costs and benefits , anesthesia, general

Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

Thomas K. Henthorn, M.D.; Michael J. Avram, Ph.D.; Albert Dahan, M.D., Ph.D.; Lars L. Gustafsson, M.D., Ph.D.; Jan Persson, M.D., Ph.D.; Tom C. Krejcie, M.D.; Erik Olofsen, Ph.D.

Anesthesiology August 2018, Vol. 129, 260–270. https://doi.org/10.1097/ALN.0000000000002265

View Articletitled, Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

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Topics: ketamine , plasma , drug concentration , infusion procedures , arm

Perioperative Medicine: Basic Science

Nuclear Spin Attenuates the Anesthetic Potency of Xenon Isotopes in Mice: Implications for the Mechanisms of Anesthesia and Consciousness

Na Li, M.D.; Dongshi Lu, M.D.; Lei Yang, M.D., Ph.D.; Huan Tao, M.D.; Younian Xu, M.D., Ph.D.; Chenchen Wang, M.D.; Lisha Fu, M.D.; Hui Liu, Ph.D.; Yatisha Chummum, M.D.; Shihai Zhang, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 271–277. https://doi.org/10.1097/ALN.0000000000002226

View Articletitled, Nuclear Spin Attenuates the Anesthetic Potency of Xenon Isotopes in Mice: Implications for the Mechanisms of Anesthesia and Consciousness

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Topics: consciousness related finding , isoflurane , mice , righting reactions , xenon

Ketamine Alters Hippocampal Cell Proliferation and Improves Learning in Mice after Traumatic Brain Injury

Austin J. Peters, M.D.; Laura E. Villasana, Ph.D.; Eric Schnell, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 278–295. https://doi.org/10.1097/ALN.0000000000002197

View Articletitled, Ketamine Alters Hippocampal Cell Proliferation and Improves Learning in Mice after Traumatic Brain Injury

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Topics: hippocampus , ketamine , mice , traumatic brain injuries , cell proliferation

Critical Care Medicine: Basic Science

Guanylyl Cyclase A in Both Renal Proximal Tubular and Vascular Endothelial Cells Protects the Kidney against Acute Injury in Rodent Experimental Endotoxemia Models

Hiroaki Kitamura, M.D.; Daisuke Nakano, Ph.D.; Yoshiharu Sawanobori, M.D.; Takehiko Asaga, M.D., Ph.D.; Hideki Yokoi, M.D., Ph.D.; Motoko Yanagita, M.D., Ph.D.; Masashi Mukoyama, M.D., Ph.D.; Takeshi Tokudome, M.D., Ph.D.; Kenji Kangawa, Ph.D.; Gotaro Shirakami, M.D., Ph.D.; Akira Nishiyama, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 296–310. https://doi.org/10.1097/ALN.0000000000002214

View Articletitled, Guanylyl Cyclase A in Both Renal Proximal Tubular and Vascular Endothelial Cells Protects the Kidney against Acute Injury in Rodent Experimental Endotoxemia Models

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Topics: atrial natriuretic factor , endothelial cells , fluid flow , fluid resuscitation , guanylate cyclase

Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11–dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome

Fang Song, M.Sc.; Jinchao Hou, Ph.D.; Zhecong Chen, M.Sc.; Baoli Cheng, Ph.D.; Ruyi Lei, M.Sc.; Ping Cui, M.Sc.; Yaqi Sun, M.Sc.; Haihong Wang, Ph.D.; Xiangming Fang, M.D.

Anesthesiology August 2018, Vol. 129, 311–320. https://doi.org/10.1097/ALN.0000000000002196

View Articletitled, Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11–dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome

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Topics: caspases , macrophages , pyroptosis , sepsis , signal transduction

Critical Care Medicine: Clinical Science

Comparison of Tracheal Intubation Conditions in Operating Room and Intensive Care Unit: A Prospective, Observational Study

Manuel Taboada, M.D., Ph.D.; Patricia Doldan, M.D.; Andrea Calvo, M.D.; Xavier Almeida, M.D.; Esteban Ferreiroa, M.D.; Aurora Baluja, M.D., Ph.D.; Agustin Cariñena, M.D.; Paula Otero, M.D.; Valentin Caruezo, M.D.; Alberto Naveira, M.D.; Pablo Otero, M.D.; Julian Alvarez, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 321–328. https://doi.org/10.1097/ALN.0000000000002269

View Articletitled, Comparison of Tracheal Intubation Conditions in Operating Room and Intensive Care Unit: A Prospective, Observational Study

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Topics: endotracheal intubation , intensive care unit , intubation , operating room , laryngoscopy, direct

Education: Classic Papers Revisited

Classic Papers Revisited: My Love Affair with the Venous System

Simon Gelman, M.D., Ph.D., F.A.N.Z.C.A.

Anesthesiology August 2018, Vol. 129, 329–332. https://doi.org/10.1097/ALN.0000000000002280

View Articletitled, Classic Papers Revisited: My Love Affair with the Venous System

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Topics: aortic cross clamping , love , blood volume , vasculature

Education: Images in Anesthesiology

Application of Focused Assessment Ultrasound in Trauma to Perioperative Medicine: A Tool to Quickly Diagnose Postoperative Hemorrhage

Stephen M. Howell, M.D.; David A. Bennion, M.D.; Nezar Jrebi, M.D.; Hong Wang, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 333. https://doi.org/10.1097/ALN.0000000000002170

View Articletitled, Application of Focused Assessment Ultrasound in Trauma to Perioperative Medicine: A Tool to Quickly Diagnose Postoperative Hemorrhage

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Topics: perioperative medicine , postoperative hemorrhage , ultrasonography , wounds and injuries

Adenoid Facies

Annie J. Sheeba, M.D.; Satvinder Singh Bakshi, M.S., D.N.B.

Anesthesiology August 2018, Vol. 129, 334. https://doi.org/10.1097/ALN.0000000000002188

View Articletitled, Adenoid Facies

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Topics: adenoid facies

Education: Clinical Focus Review

Presumed β-Lactam Allergy and Cross-reactivity in the Operating Theater: A Practical Approach

Jeroen Hermanides, M.D., Ph.D.; Bregtje A. Lemkes, M.D., Ph.D.; Jan M. Prins, M.D., Ph.D.; Markus W. Hollmann, M.D., Ph.D.; Ingrid Terreehorst, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 335–342. https://doi.org/10.1097/ALN.0000000000002252

View Articletitled, Presumed β-Lactam Allergy and Cross-reactivity in the Operating Theater: A Practical Approach

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Topics: cross reactions , hypersensitivity , lactams , operating room , penicillin

Education: Review Article

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Ru-Rong Ji, Ph.D.; Andrea Nackley, Ph.D.; Yul Huh, B.S., M.S.; Niccolò Terrando, Ph.D.; William Maixner, D.D.S., Ph.D.

Anesthesiology August 2018, Vol. 129, 343–366. https://doi.org/10.1097/ALN.0000000000002130

View Articletitled, Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

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Topics: central sensitization , pain , chronic pain , spinal cord

Education: Mind to Mind

Liquid Lightness
Part of the Letheon Writing Competition

Kate Walker

Anesthesiology August 2018, Vol. 129, 367. https://doi.org/10.1097/ALN.0000000000002262

View Articletitled, Liquid Lightness

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Topics: consciousness related finding , sirenomelia , uterus , voice

Subjective Objective: A Researcher’s Narrative on Human Relationships

Jennifer M. O’Brien, Ph.D.

Anesthesiology August 2018, Vol. 129, 368–370. https://doi.org/10.1097/ALN.0000000000002168

View Articletitled, Subjective Objective: A Researcher’s Narrative on Human Relationships

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Topics: narrative discourse , child

Correspondence

Modeling the Effects of the Locked Pack Procedure to Prevent Guidewire Retention in a Clinical Setting

Enrico Camporesi, M.D.; Garrett Enten, B.S.; Hesham R. Omar, M.D.; Devanand Mangar, M.D.

Anesthesiology August 2018, Vol. 129, 371. https://doi.org/10.1097/ALN.0000000000002308

View Articletitled, Modeling the Effects of the Locked Pack Procedure to Prevent Guidewire Retention in a Clinical Setting

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Retained Central Venous Guidewires: Are We Flushing Them Out?

Ritoo Kapoor, F.C.A.R.C.S.I.; Martin Mayall, F.R.C.A., E.D.I.C., M.B.A.

Anesthesiology August 2018, Vol. 129, 371–372. https://doi.org/10.1097/ALN.0000000000002309

View Articletitled, Retained Central Venous Guidewires: Are We Flushing Them Out?

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In Reply

Maryanne Z. A. Mariyaselvam, M.B.B.S.; Peter J. Young, M.D.

Anesthesiology August 2018, Vol. 129, 372–373. https://doi.org/10.1097/ALN.0000000000002310

View Articletitled, In Reply

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Pharmacokinetic Pharmacodynamic Perspective on the Detection of Signs of Neural Inertia in Humans

Pieter J. Colin, Pharm.D., Ph.D.; Merel H. Kuizenga, M.D.; Hugo E. M. Vereecke, M.D., Ph.D.; Michel M. R. F. Struys, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 373–375. https://doi.org/10.1097/ALN.0000000000002287

View Articletitled, Pharmacokinetic Pharmacodynamic Perspective on the Detection of Signs of Neural Inertia in Humans

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Electroencephalogram and Anesthetics

Arthur E. Schwartz, M.D.

Anesthesiology August 2018, Vol. 129, 375. https://doi.org/10.1097/ALN.0000000000002288

View Articletitled, Electroencephalogram and Anesthetics

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In Reply

Catherine E. Warnaby, Ph.D.; Jamie W. Sleigh, M.D.; Irene Tracey, M.A. (Oxon), D.Phil., F.R.C.A., F.Med.Sci.

Anesthesiology August 2018, Vol. 129, 375–377. https://doi.org/10.1097/ALN.0000000000002289

View Articletitled, In Reply

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Risks of Impaired Organ Protection with Inhibiting Transient Receptor Potential Vanilloid 1

Yu Wu, M.D.; Eric R. Gross, M.D., Ph.D.; Jinqiao Qian, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 377–378. https://doi.org/10.1097/ALN.0000000000002293

View Articletitled, Risks of Impaired Organ Protection with Inhibiting Transient Receptor Potential Vanilloid 1

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In Reply

Andras Garami, M.D., Ph.D.; Mohab Ibrahim, M.D., Ph.D.; Kerry Gilbraith, B.S.; Rajesh Khanna, Ph.D.; Eszter Pakai, M.S.; Alexandra Miko, M.D.; Erika Pinter, M.D., Ph.D., D.Sc.; Andrej A. Romanovsky, M.D., Ph.D.; Frank Porreca, Ph.D.; Amol M. Patwardhan, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 378–379. https://doi.org/10.1097/ALN.0000000000002294

View Articletitled, In Reply

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Postoperative Analgesia after Shoulder Surgery

Dario Musso, M.D.; Øivind Klaastad, M.D., Ph.D.; Lars M. Ytrebø, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 379–380. https://doi.org/10.1097/ALN.0000000000002276

View Articletitled, Postoperative Analgesia after Shoulder Surgery

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Intraoperative Considerations of the Suprascapular Nerve Block

Ian M. Brotman, M.D.; Steven Orebaugh, M.D.

Anesthesiology August 2018, Vol. 129, 380. https://doi.org/10.1097/ALN.0000000000002277

View Articletitled, Intraoperative Considerations of the Suprascapular Nerve Block

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In Reply

Nasir Hussain, M.Sc., M.D.; Faraj W. Abdallah, M.D.

Anesthesiology August 2018, Vol. 129, 380–381. https://doi.org/10.1097/ALN.0000000000002278

View Articletitled, In Reply

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Catching a Unicorn: Neostigmine and Muscle Weakness—Not Neostigmine for All, but Quantitative Monitoring for Everyone!

Stephanie Phillips, B.Med., F.R.C.A., F.A.N.Z.C.A.; Paul A. Stewart, M.B., B.S., F.A.N.Z.C.A.

Anesthesiology August 2018, Vol. 129, 381–382. https://doi.org/10.1097/ALN.0000000000002295

View Articletitled, Catching a Unicorn: Neostigmine and Muscle Weakness—Not Neostigmine for All, but Quantitative Monitoring for Everyone!

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In Reply

Mohamed Naguib, M.D., M.Sc., F.C.A.R.C.S.I.; Sorin J. Brull, M.D., F.C.A.R.C.S.I. (Hon).

Anesthesiology August 2018, Vol. 129, 383–384. https://doi.org/10.1097/ALN.0000000000002296

View Articletitled, In Reply

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In Reply

Glenn S. Murphy, M.D.; Joseph W. Szokol, M.D.; Michael J. Avram, Ph.D.

Anesthesiology August 2018, Vol. 129, 384–385. https://doi.org/10.1097/ALN.0000000000002297

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Colloids in Major Abdominal Surgery: Are They Really Better?

Cornelis Slagt, M.D., Ph.D.; Lucas T. van Eijk, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 385–386. https://doi.org/10.1097/ALN.0000000000002291

View Articletitled, Colloids in Major Abdominal Surgery: Are They Really Better?

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In Reply

Alexandre Joosten, M.D.; Amelie Delaporte, M.D.; Joseph Rinehart, M.D.; Philippe Van der Linden, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 386–387. https://doi.org/10.1097/ALN.0000000000002292

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Central Venous Lines in Low-birth-weight Newborns: Watch Out

John G. Brock-Utne, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 387. https://doi.org/10.1097/ALN.0000000000002285

View Articletitled, Central Venous Lines in Low-birth-weight Newborns: Watch Out

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In Reply

Christian Breschan, M.D., Ph.D.

Anesthesiology August 2018, Vol. 129, 387. https://doi.org/10.1097/ALN.0000000000002286

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Anesthesiology Reflections from the Wood Library-Museum

Coca Bitters—Numbing the Fatigue Rather Than the Pain

Anesthesiology August 2018, Vol. 129, 234. https://doi.org/10.1097/ALN.0000000000002358

View Articletitled, Coca Bitters—Numbing the Fatigue Rather Than the Pain

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“No Charge” Laughing Gas at Carmichael & Company of Troy, New York

Anesthesiology August 2018, Vol. 129, 295. https://doi.org/10.1097/ALN.0000000000002359

View Articletitled, “No Charge” Laughing Gas at Carmichael & Company of Troy, New York

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Liebig’s Trade Card for Numbing but Toxic Aconite

Anesthesiology August 2018, Vol. 129, 310. https://doi.org/10.1097/ALN.0000000000002360

View Articletitled, Liebig’s Trade Card for Numbing but Toxic Aconite

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Planocaine: Procaine by May & Baker Ltd. of Dagenham

Anesthesiology August 2018, Vol. 129, 328. https://doi.org/10.1097/ALN.0000000000002361

View Articletitled, Planocaine: Procaine by May & Baker Ltd. of Dagenham

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Streams of Unconsciousness V: Stability Reflected in the Pyriphlegethon

Anesthesiology August 2018, Vol. 129, 366. https://doi.org/10.1097/ALN.0000000000002362

View Articletitled, Streams of Unconsciousness V: Stability Reflected in the Pyriphlegethon

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Erratum

Electrical Impedance Tomography for Confirmation of Lung Isolation during One-lung Ventilation: Erratum

Anesthesiology August 2018, Vol. 129, 388. https://doi.org/10.1097/ALN.0000000000002235

View Articletitled, Electrical Impedance Tomography for Confirmation of Lung Isolation during One-lung Ventilation: Erratum

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Issues

Cover Image

Table of Contents

Editorial Board

This Month in Anesthesiology

Science, Medicine, and the Anesthesiologist

Infographics in Anesthesiology

Anesthesiology CME Program

Editorial

Perioperative Medicine: Clinical Science

Perioperative Medicine: Basic Science

Critical Care Medicine: Basic Science

Critical Care Medicine: Clinical Science

Education: Classic Papers Revisited

Education: Images in Anesthesiology

Education: Clinical Focus Review

Education: Review Article

Education: Mind to Mind

Liquid Lightness Part of the Letheon Writing Competition

Correspondence

Anesthesiology Reflections from the Wood Library-Museum

Erratum

Email alerts

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Liquid Lightness
Part of the Letheon Writing Competition