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Issues

Volume 125, Issue 6
December 2016
Issue Cover
All Issues

Table of Contents

Anesthesiology
Anesthesiology December 2016, Vol. 125, A13–A17. https://doi.org/10.1097/ALN.0000000000001463
View Articletitled, Anesthesiology
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Editorial Board

Anesthesiology
Anesthesiology December 2016, Vol. 125, A15–A16. https://doi.org/10.1097/ALN.0000000000001417
View Articletitled, Anesthesiology
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This Month in Anesthesiology

This Month in: Anesthesiology
Anesthesiology December 2016, Vol. 125, A1–A2. https://doi.org/10.1097/ALN.0000000000001416
View Articletitled, This Month in: Anesthesiology
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Science, Medicine, and the Anesthesiologist

Science, Medicine, and the Anesthesiologist
Anesthesiology December 2016, Vol. 125, A19–A20. https://doi.org/10.1097/ALN.0000000000001418
View Articletitled, Science, Medicine, and the Anesthesiologist
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Infographics in Anesthesiology

Understanding Intravenous General Anesthetics
James P. Rathmell; Stuart Forman; Jonathan P. Wanderer
Anesthesiology December 2016, Vol. 125, A21. https://doi.org/10.1097/ALN.0000000000001420
View Articletitled, Understanding Intravenous General Anesthetics
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Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit
Anesthesiology December 2016, Vol. 125, A17. https://doi.org/10.1097/ALN.0000000000001419
View Articletitled, Instructions for Obtaining A<span class="small-caps">nesthesiology</span> Continuing Medical Education (CME) Credit
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Editorial

Protective Ventilation during Anesthesia: Is It Meaningful?
Göran Hedenstierna, M.D., Ph.D.; Lennart Edmark, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1079–1082. https://doi.org/10.1097/ALN.0000000000001382
View Articletitled, Protective Ventilation during Anesthesia<span class="subtitle-colon">: </span><span class="subtitle">Is It Meaningful?</span>
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Do Not Use Hierarchical Logistic Regression Models with Low-incidence Outcome Data to Compare Anesthesiologists in Your Department
Franklin Dexter, M.D., Ph.D.; Bradley J. Hindman, M.D.
Anesthesiology December 2016, Vol. 125, 1083–1084. https://doi.org/10.1097/ALN.0000000000001363
View Articletitled, Do Not Use Hierarchical Logistic Regression Models with Low-incidence Outcome Data to Compare Anesthesiologists in Your Department
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CYP2B6*6 or Not CYP2B6*6—That Remains a Question for Precision Medicine and Ketamine!
Scott D. Cook-Sather, M.D.; Peter C. Adamson, M.D.; Jin Li, Ph.D.; Hakon Hakonarson, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1085–1087. https://doi.org/10.1097/ALN.0000000000001399
View Articletitled, <em>CYP2B6*6</em> or Not <em>CYP2B6*6—</em>That Remains a Question for Precision Medicine and Ketamine!
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Anesthetic–Receptor Relationship Status: It’s Complicated
Meagan A. Jenkins, Ph.D.; Andrew Jenkins, Ph.D.
Anesthesiology December 2016, Vol. 125, 1088–1089. https://doi.org/10.1097/ALN.0000000000001391
View Articletitled, Anesthetic–Receptor Relationship Status: It’s Complicated
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Anesthesia Kills Brain Cells, but What Does It Mean?
Jeffrey W. Sall, Ph.D., M.D.
Anesthesiology December 2016, Vol. 125, 1090–1091. https://doi.org/10.1097/ALN.0000000000001359
View Articletitled, Anesthesia Kills Brain Cells, but What Does It Mean?
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Perioperative Medicine: Clinical Science

Quality of Quality Measurement: Impact of Risk Adjustment, Hospital Volume, and Hospital Performance
Laurent G. Glance, M.D.; Yue Li, Ph.D.; Andrew W. Dick, Ph.D.
Anesthesiology December 2016, Vol. 125, 1092–1102. https://doi.org/10.1097/ALN.0000000000001362
View Articletitled, Quality of Quality Measurement<span class="subtitle-colon">: </span><span class="subtitle">Impact of Risk Adjustment, Hospital Volume, and Hospital Performance</span>
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Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance
Lesley K. Rao, M.D.; Alicia M. Flaker, A.S.; Christina C. Friedel, B.S.; Evan D. Kharasch, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1103–1112. https://doi.org/10.1097/ALN.0000000000001392
View Articletitled, Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance
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Effectiveness of an Electronic Alert for Hypotension and Low Bispectral Index on 90-day Postoperative Mortality: A Prospective, Randomized Trial
Patrick J. McCormick, M.D.; Matthew A. Levin, M.D.; Hung-Mo Lin, Sc.D.; Daniel I. Sessler, M.D.; David L. Reich, M.D.
Anesthesiology December 2016, Vol. 125, 1113–1120. https://doi.org/10.1097/ALN.0000000000001296
View Articletitled, Effectiveness of an Electronic Alert for Hypotension and Low Bispectral Index on 90-day Postoperative Mortality<span class="subtitle-colon">: </span><span class="subtitle">A Prospective, Randomized Trial</span>
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Perioperative Aspirin for Prevention of Venous Thromboembolism: The PeriOperative ISchemia Evaluation-2 Trial and a Pooled Analysis of the Randomized Trials
John W. Eikelboom, M.B.B.S.; Clive Kearon, M.D.; Gordon Guyatt, M.D.; Daniel I. Sessler, M.D.; Salim Yusuf, M.D.; Deborah Cook, M.D.; James Douketis, M.D.; Ameen Patel, M.D.; Andrea Kurz, M.D.; Rene Allard, M.D.; Philip M. Jones, M.D.; Rodolfo J. Dennis, M.D.; Thomas W. Painter, M.B.Ch.B.; Sergio D. Bergese, M.D.; Kate Leslie, M.D.; Duminda N. Wijeysundera, M.D., Ph.D.; Kumar Balasubramanian, M.Sc.; Emmanuelle Duceppe, M.D.; Scott Miller, M.D.; Johan Diedericks, M.D.; P. J. Devereaux, Ph.D.
Anesthesiology December 2016, Vol. 125, 1121–1129. https://doi.org/10.1097/ALN.0000000000001352
View Articletitled, Perioperative Aspirin for Prevention of Venous Thromboembolism<span class="subtitle-colon">: </span><span class="subtitle">The PeriOperative ISchemia Evaluation-2 Trial and a Pooled Analysis of the Randomized Trials</span>
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Median Effective Dose of Intranasal Dexmedetomidine for Rescue Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging
Wenhua Zhang, M.D.; Yanting Fan, M.D.; Tianyun Zhao, M.D.; Jinghui Chen, M.D.; Gaolong Zhang, M.D.; Xingrong Song, M.D.
Anesthesiology December 2016, Vol. 125, 1130–1135. https://doi.org/10.1097/ALN.0000000000001353
View Articletitled, Median Effective Dose of Intranasal Dexmedetomidine for Rescue Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging
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Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Paul M. Heerdt, M.D., Ph.D.; Hiroshi Sunaga, M.D.; Joel S. Owen, Ph.D.; Matthew T. Murrell, M.D., Ph.D.; Jaideep K. Malhotra, M.D.; Deena Godfrey, B.A.; Michelle Steinkamp, R.N.; Peter Savard, M.D.; John J. Savarese, M.D.; Cynthia A. Lien, M.D.
Anesthesiology December 2016, Vol. 125, 1136–1143. https://doi.org/10.1097/ALN.0000000000001386
View Articletitled, Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
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Perioperative Medicine: Basic Science

Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site
Anahita Nourmahnad, B.S.; Alex T. Stern, B.S.; Mayo Hotta, B.S.; Deirdre S. Stewart, Ph.D.; Alexis M. Ziemba, B.A.; Andrea Szabo, B.S.; Stuart A. Forman, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1144–1158. https://doi.org/10.1097/ALN.0000000000001390
View Articletitled, Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site
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Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity
Yifei Jiang, M.D., Ph.D.; Dongyi Tong, M.D.; Rylon D. Hofacer, B.S.; Andreas W. Loepke, M.D., Ph.D.; Qingquan Lian, M.D., Ph.D.; Steve C. Danzer, Ph.D.
Anesthesiology December 2016, Vol. 125, 1159–1170. https://doi.org/10.1097/ALN.0000000000001358
View Articletitled, Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity
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Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia–reperfusion Injury in Rodents
Yao Lu, M.D.; Honit Piplani, Ph.D.; Stacy L. McAllister, Ph.D.; Carl M. Hurt, M.D., Ph.D.; Eric R. Gross, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1171–1180. https://doi.org/10.1097/ALN.0000000000001377
View Articletitled, Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia–reperfusion Injury in Rodents
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Critical Care Medicine: Clinical Science

New Setting of Neurally Adjusted Ventilatory Assist during Noninvasive Ventilation through a Helmet
Gianmaria Cammarota, M.D., Ph.D.; Federico Longhini, M.D.; Raffaella Perucca, M.D.; Chiara Ronco, M.D.; Davide Colombo, M.D., Ph.D.; Antonio Messina, M.D., Ph.D.; Rosanna Vaschetto, M.D., Ph.D.; Paolo Navalesi, M.D., F.E.R.S.
Anesthesiology December 2016, Vol. 125, 1181–1189. https://doi.org/10.1097/ALN.0000000000001354
View Articletitled, New Setting of Neurally Adjusted Ventilatory Assist during Noninvasive Ventilation through a Helmet
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Critical Care Medicine: Basic Science

Heme Oxygenase-1/Carbon Monoxide-regulated Mitochondrial Dynamic Equilibrium Contributes to the Attenuation of Endotoxin-induced Acute Lung Injury in Rats and in Lipopolysaccharide-activated Macrophages
Jianbo Yu, M.D., Ph.D.; Jia Shi, M.Sc.; Dan Wang, M.Sc.; Shuan Dong, M.Sc.; Yuan Zhang, M.Sc.; Man Wang, M.Sc.; Lirong Gong, M.Sc.; Qiang Fu, M.D., Ph.D.; Daquan Liu, M.Sc.
Anesthesiology December 2016, Vol. 125, 1190–1201. https://doi.org/10.1097/ALN.0000000000001333
View Articletitled, Heme Oxygenase-1/Carbon Monoxide-regulated Mitochondrial Dynamic Equilibrium Contributes to the Attenuation of Endotoxin-induced Acute Lung Injury in Rats and in Lipopolysaccharide-activated Macrophages
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Pain Medicine: Basic Science

Neurosteroid Allopregnanolone Suppresses Median Nerve Injury–induced Mechanical Hypersensitivity and Glial Extracellular Signal–regulated Kinase Activation through γ-Aminobutyric Acid Type A Receptor Modulation in the Rat Cuneate Nucleus
Chun-Ta Huang, M.D.; Seu-Hwa Chen, Ph.D.; June-Horng Lue, Ph.D.; Chi-Fen Chang, Ph.D.; Wen-Hsin Wen, M.D.; Yi-Ju Tsai, Ph.D.
Anesthesiology December 2016, Vol. 125, 1202–1218. https://doi.org/10.1097/ALN.0000000000001360
View Articletitled, Neurosteroid Allopregnanolone Suppresses Median Nerve Injury–induced Mechanical Hypersensitivity and Glial Extracellular Signal–regulated Kinase Activation through γ-Aminobutyric Acid Type A Receptor Modulation in the Rat Cuneate Nucleus
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Education: Images in Anesthesiology

Images in Anesthesiology: Skin Mottling after Induction
Emily E. Naoum, M.D.; Luke S. Oh, M.D.; Wilton C. Levine, M.D.
Anesthesiology December 2016, Vol. 125, 1219. https://doi.org/10.1097/ALN.0000000000001216
View Articletitled, Images in Anesthesiology: Skin Mottling after Induction
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Portal Catheter Fracture in a Pediatric Patient
Antoinette Van Meter, M.D.; Acsa Zavala, M.D.; Uduak U. Williams, M.D.; Pascal Owusu-Agyemang, M.D.
Anesthesiology December 2016, Vol. 125, 1220. https://doi.org/10.1097/ALN.0000000000001215
View Articletitled, Portal Catheter Fracture in a Pediatric Patient
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Education: Original Investigations in Education

Appropriateness of Language Used in Patient Educational Materials from 24 National Anesthesiology Associations
Denira Govender, B.Sc.; Alexander Villafranca, M.Sc.; Colin Hamlin, M.A.; Brett Hiebert, M.Sc.; Divya Parveen, B.Sc.; Eric Jacobsohn, M.B.Ch.B.
Anesthesiology December 2016, Vol. 125, 1221–1228. https://doi.org/10.1097/ALN.0000000000001361
View Articletitled, Appropriateness of Language Used in Patient Educational Materials from 24 National Anesthesiology Associations
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Education: Clinical Concepts and Commentary

Intensive Care Unit Delirium: A Review of Diagnosis, Prevention, and Treatment
Christina J. Hayhurst, M.D.; Pratik P. Pandharipande, M.D.; Christopher G. Hughes, M.D.
Anesthesiology December 2016, Vol. 125, 1229–1241. https://doi.org/10.1097/ALN.0000000000001378
View Articletitled, Intensive Care Unit Delirium<span class="subtitle-colon">: </span><span class="subtitle">A Review of Diagnosis, Prevention, and Treatment</span>
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Education: Mind to Mind

Going Home
Alicia M. Kowalski, M.D.
Anesthesiology December 2016, Vol. 125, 1242–1243. https://doi.org/10.1097/ALN.0000000000001319
View Articletitled, Going Home
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A Proper Burial
Brian D. Sites, M.D., M.S.
Anesthesiology December 2016, Vol. 125, 1244–1245. https://doi.org/10.1097/ALN.0000000000001318
View Articletitled, A Proper Burial
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Correspondence

Pure Science or Purely Biased
Warren J. Levy, M.D.
Anesthesiology December 2016, Vol. 125, 1246. https://doi.org/10.1097/ALN.0000000000001368
View Articletitled, Pure Science or Purely Biased
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High versus Low Technology in Assessment of Endotracheal Tube Position
Hans-Joachim Priebe, M.D.
Anesthesiology December 2016, Vol. 125, 1246–1247. https://doi.org/10.1097/ALN.0000000000001370
View Articletitled, High <em>versus</em> Low Technology in Assessment of Endotracheal Tube Position
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“We Hear What You Are Saying, but…”
Douglas L. Hester, M.D.; Stephen T. Harvey, M.D.
Anesthesiology December 2016, Vol. 125, 1247–1248. https://doi.org/10.1097/ALN.0000000000001371
View Articletitled, “We Hear What You Are Saying, but…”
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Detection of Inadvertent Endobronchial Intubation
Mohammad El-Orbany, M.D.
Anesthesiology December 2016, Vol. 125, 1248. https://doi.org/10.1097/ALN.0000000000001372
View Articletitled, Detection of Inadvertent Endobronchial Intubation
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The Value of the Stethoscope in the Era of Ultrasound
Mitchell L. Jablons, M.D.
Anesthesiology December 2016, Vol. 125, 1248–1249. https://doi.org/10.1097/ALN.0000000000001373
View Articletitled, The Value of the Stethoscope in the Era of Ultrasound
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In Reply
Shiroh Isono, M.D., Ph.D.; Warren S. Sandberg, M.D., Ph.D.; Yandong Jiang, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1249–1250. https://doi.org/10.1097/ALN.0000000000001374
View Articletitled, In Reply
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In Reply
Davinder Ramsingh, M.D.; Maxime Cannesson, M.D., Ph.D.
Anesthesiology December 2016, Vol. 125, 1250–1251. https://doi.org/10.1097/ALN.0000000000001375
View Articletitled, In Reply
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Assessing the Effect of Exogenous Albumin on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
Wei Zhang, M.D.; Feng Xue, M.D.
Anesthesiology December 2016, Vol. 125, 1251–1252. https://doi.org/10.1097/ALN.0000000000001347
View Articletitled, Assessing the Effect of Exogenous Albumin on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
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In Reply
Eun-Ho Lee, M.D.; In-Cheol Choi, M.D.
Anesthesiology December 2016, Vol. 125, 1252–1253. https://doi.org/10.1097/ALN.0000000000001348
View Articletitled, In Reply
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Complications of One-lung Ventilation: Is It the Blood Flow or the Ventilation?
Jonathan V. Roth, M.D.
Anesthesiology December 2016, Vol. 125, 1253–1254. https://doi.org/10.1097/ALN.0000000000001349
View Articletitled, Complications of One-lung Ventilation: Is It the Blood Flow or the Ventilation?
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Selecting the Level of Positive End-expiratory Pressure for One-lung Ventilation: “By Formula” or “By Feel”?
John Pfitzner, M.B.B.S., F.R.C.A.
Anesthesiology December 2016, Vol. 125, 1254–1255. https://doi.org/10.1097/ALN.0000000000001350
View Articletitled, Selecting the Level of Positive End-expiratory Pressure for One-lung Ventilation: “By Formula” or “By Feel”?
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Acknowledgment

Acknowledgment
Anesthesiology December 2016, Vol. 125, 1256–1258. https://doi.org/10.1097/ALN.0000000000001421
View Articletitled, Acknowledgment
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Anesthesiology Reflections from the Wood Library-Museum

Shock and Aftershock: How a Surgeon Trying to Prevent Brain Damage Inspired a “Physiologist” to Cause It…Unwittingly
Anesthesiology December 2016, Vol. 125, 1102. https://doi.org/10.1097/ALN.0000000000001422
View Articletitled, Shock and Aftershock: How a Surgeon Trying to Prevent Brain Damage Inspired a “Physiologist” to Cause It…Unwittingly
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Cartoon by “AB” of a Dentist Anesthetist Who “Ran No Risks”
Anesthesiology December 2016, Vol. 125, 1135. https://doi.org/10.1097/ALN.0000000000001423
View Articletitled, Cartoon by “AB” of a Dentist Anesthetist Who “Ran No Risks”
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Moynihan Syringe for Quinine and Urea Local Anesthesia
Anesthesiology December 2016, Vol. 125, 1170. https://doi.org/10.1097/ALN.0000000000001424
View Articletitled, Moynihan Syringe for Quinine and Urea Local Anesthesia
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The Ultimate Anesthetic? The Endlessly Sleeping Endymion of Cornacchini
Anesthesiology December 2016, Vol. 125, 1189. https://doi.org/10.1097/ALN.0000000000001425
View Articletitled, The Ultimate Anesthetic? The Endlessly <em>Sleeping Endymion</em> of Cornacchini
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“Dr. Dewees’s Anaesthetic Inhaler” for Ether or Chloroform
Anesthesiology December 2016, Vol. 125, 1201. https://doi.org/10.1097/ALN.0000000000001426
View Articletitled, “Dr. Dewees’s Anaesthetic Inhaler” for Ether or Chloroform
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Courville, Aoyagi, and ASA: 1936 Was a Banner Year!
Anesthesiology December 2016, Vol. 125, 1218. https://doi.org/10.1097/ALN.0000000000001427
View Articletitled, Courville, Aoyagi, and ASA: 1936 Was a Banner Year!
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