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Issues

Volume 124, Issue 4
April 2016
Issue Cover
All Issues

Table of Contents

Anesthesiology
Anesthesiology April 2016, Vol. 124, A13–A18. https://doi.org/10.1097/01.anes.0000480994.22684.1d
View Articletitled, Anesthesiology
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Editorial Board

Anesthesiology
Anesthesiology April 2016, Vol. 124, A15–A16. https://doi.org/10.1097/01.anes.0000480993.22684.d3
View Articletitled, Anesthesiology
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This Month in Anesthesiology

This Month in: Anesthesiology
Anesthesiology April 2016, Vol. 124, A1–A2. https://doi.org/10.1097/01.anes.0000480991.37931.bb
View Articletitled, This Month in: Anesthesiology
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Science, Medicine, and the Anesthesiologist

Science, Medicine, and the Anesthesiologist
Anesthesiology April 2016, Vol. 124, A19–A20. https://doi.org/10.1097/01.anes.0000480995.30308.e7
View Articletitled, Science, Medicine, and the Anesthesiologist
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Infographics in Anesthesiology

Unraveling the Neurobiology of Consciousness: Anesthesia, Loss of Behavioral Response to Stimuli, and Functional Connectivity in the Brain
James P. Rathmell; Jonathan P. Wanderer
Anesthesiology April 2016, Vol. 124, A21. https://doi.org/10.1097/01.anes.0000480996.68425.66
View Articletitled, Unraveling the Neurobiology of Consciousness<span class="subtitle-colon">: </span><span class="subtitle">Anesthesia, Loss of Behavioral Response to Stimuli, and Functional Connectivity in the Brain</span>
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Anesthesiology CME Program

Instructions for Obtaining Anesthesiology Continuing Medical Education (CME) Credit
Anesthesiology April 2016, Vol. 124, A17. https://doi.org/10.1097/01.anes.0000480992.45555.57
View Articletitled, Instructions for Obtaining A<span class="small-caps">nesthesiology</span> Continuing Medical Education (CME) Credit
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Editorial

Anesthetizing the Self: The Neurobiology of Humbug
George A. Mashour, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 747–749. https://doi.org/10.1097/ALN.0000000000001028
View Articletitled, Anesthetizing the Self<span class="subtitle-colon">: </span><span class="subtitle">The Neurobiology of Humbug</span>
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When Seconds Count, Buy More Time: The Oxygen Reserve Index and Its Promising Role in Patient Monitoring and Safety
Allan F. Simpao, M.D., M.B.I.; Jorge A. Gálvez, M.D.
Anesthesiology April 2016, Vol. 124, 750–751. https://doi.org/10.1097/ALN.0000000000001036
View Articletitled, When Seconds Count, Buy More Time<span class="subtitle-colon">: </span><span class="subtitle">The Oxygen Reserve Index and Its Promising Role in Patient Monitoring and Safety</span>
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Injection Rhymes with Infection?
Warren S. Sandberg, M.D., Ph.D.; Thomas R. Talbot, M.D., M.P.H.
Anesthesiology April 2016, Vol. 124, 752–754. https://doi.org/10.1097/ALN.0000000000001042
View Articletitled, Injection Rhymes with Infection?
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If I Had a Hammer: Building Alignment and Accountability
David L. Hepner, M.D., M.P.H.; Angela M. Bader, M.D., M.P.H.
Anesthesiology April 2016, Vol. 124, 755–757. https://doi.org/10.1097/ALN.0000000000001014
View Articletitled, If I Had a Hammer<span class="subtitle-colon">: </span><span class="subtitle">Building Alignment and Accountability</span>
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More Than Anyone Else: Preemies Need Good Analgesia
Laszlo Vutskits, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 758–760. https://doi.org/10.1097/ALN.0000000000001018
View Articletitled, More Than Anyone Else<span class="subtitle-colon">: </span><span class="subtitle">Preemies Need Good Analgesia</span>
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Intensive Care after High-risk Surgery: What’s in a Name?
Michael A. Gillies, M.D., F.R.C.A.; Rupert M. Pearse, M.D., F.R.C.A.
Anesthesiology April 2016, Vol. 124, 761–762. https://doi.org/10.1097/ALN.0000000000001025
View Articletitled, Intensive Care after High-risk Surgery<span class="subtitle-colon">: </span><span class="subtitle">What’s in a Name?</span>
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Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement
James C. Eisenach, M.D.; David S. Warner, M.D.; Timothy T. Houle, Ph.D.
Anesthesiology April 2016, Vol. 124, 763–765. https://doi.org/10.1097/ALN.0000000000001044
View Articletitled, Reporting of Preclinical Research in A<span class="small-caps">nesthesiology</span><span class="subtitle-colon">: </span><span class="subtitle">Transparency and Enforcement</span>
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Perioperative Medicine: Clinical Science

Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response
Catherine Elizabeth Warnaby, Ph.D.; Marta Seretny, M.D.; Roísín Ní Mhuircheartaigh, M.D., D.Phil.; Richard Rogers, M.D.; Saad Jbabdi, Ph.D.; Jamie Sleigh, M.D.; Irene Tracey, M.A. (Oxon), D.Phil., F.R.C.A., F.Med.Sci.
Anesthesiology April 2016, Vol. 124, 766–778. https://doi.org/10.1097/ALN.0000000000001027
View Articletitled, Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response
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Oxygen Reserve Index: A Novel Noninvasive Measure of Oxygen Reserve—A Pilot Study
Peter Szmuk, M.D.; Jeffrey W. Steiner, D.O.; Patrick N. Olomu, M.D.; Roxana P. Ploski, B.S.; Daniel I. Sessler, M.D.; Tiberiu Ezri, M.D.
Anesthesiology April 2016, Vol. 124, 779–784. https://doi.org/10.1097/ALN.0000000000001009
View Articletitled, Oxygen Reserve Index<span class="subtitle-colon">: </span><span class="subtitle">A Novel Noninvasive Measure of Oxygen Reserve—A Pilot Study</span>
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Microbiological Contamination of Drugs during Their Administration for Anesthesia in the Operating Room
Derryn A. Gargiulo, M.Pharm.Clin., Reg.Pharm.N.Z.; Simon J. Mitchell, Ph.D., F.A.N.Z.C.A.; Janie Sheridan, Ph.D., Reg.Pharm.N.Z., F.R.Pharm.S.; Timothy G. Short, M.B.Ch.B., M.D., F.A.N.Z.C.A.; Simon Swift, Ph.D.; Jane Torrie, M.B.Ch.B., F.A.N.Z.C.A.; Craig S. Webster, Ph.D.; Alan F. Merry, M.B.Ch.B., F.F.P.M.A.N.Z.C.A., F.R.C.A., F.A.N.Z.C.A.
Anesthesiology April 2016, Vol. 124, 785–794. https://doi.org/10.1097/ALN.0000000000001041
View Articletitled, Microbiological Contamination of Drugs during Their Administration for Anesthesia in the Operating Room
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A Human Factors Engineering Study of the Medication Delivery Process during an Anesthetic: Self-filled Syringes versus Prefilled Syringes
Yushi Yang, Ph.D.; Antonia Joy Rivera, Ph.D.; Christopher R. Fortier, Pharm.D.; James H. Abernathy, III, M.D., M.P.H.
Anesthesiology April 2016, Vol. 124, 795–803. https://doi.org/10.1097/ALN.0000000000001040
View Articletitled, A Human Factors Engineering Study of the Medication Delivery Process during an Anesthetic<span class="subtitle-colon">: </span><span class="subtitle">Self-filled Syringes <em>versus</em> Prefilled Syringes</span>
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Preoperative Laboratory Investigations: Rates and Variability Prior to Low-risk Surgical Procedures
Kyle R. Kirkham, M.D.; Duminda N. Wijeysundera, M.D., Ph.D.; Ciara Pendrith, M.Sc.; Ryan Ng, M.Sc.; Jack V. Tu, M.D., Ph.D.; Andrew S. Boozary, M.D., M.P.P.; Joshua Tepper, M.D., M.P.H., M.B.A.; Michael J. Schull, M.D., M.Sc.; Wendy Levinson, M.D.; R. Sacha Bhatia, M.D., M.B.A.
Anesthesiology April 2016, Vol. 124, 804–814. https://doi.org/10.1097/ALN.0000000000001013
View Articletitled, Preoperative Laboratory Investigations<span class="subtitle-colon">: </span><span class="subtitle">Rates and Variability Prior to Low-risk Surgical Procedures</span>
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Self-reported Mobility in Older Patients Predicts Early Postoperative Outcomes after Elective Noncardiac Surgery
Sunghye Kim, M.D., M.M.Sc.; Anthony P. Marsh, Ph.D.; Lauren Rustowicz, B.S.; Catherine Roach, B.S.; Xiaoyan I. Leng, M.D., Ph.D.; Stephen B. Kritchevsky, Ph.D.; W. Jack Rejeski, Ph.D.; Leanne Groban, M.D., M.S.
Anesthesiology April 2016, Vol. 124, 815–825. https://doi.org/10.1097/ALN.0000000000001011
View Articletitled, Self-reported Mobility in Older Patients Predicts Early Postoperative Outcomes after Elective Noncardiac Surgery
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Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial
Alain Deschamps, Ph.D., M.D.; Richard Hall, M.D.; Hilary Grocott, M.D.; C. David Mazer, M.D.; Peter T. Choi, M.D.; Alexis F. Turgeon, M.D., M.Sc.; Etienne de Medicis, M.D.; Jean S. Bussières, M.D.; Christopher Hudson, M.D.; Summer Syed, M.D.; Doug Seal, M.D.; Stuart Herd, M.D.; Jean Lambert, Ph.D.; André Denault, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 826–836. https://doi.org/10.1097/ALN.0000000000001029
View Articletitled, Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery<span class="subtitle-colon">: </span><span class="subtitle">A Randomized Controlled Feasibility Trial</span>
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Variations in the Use of Perioperative Multimodal Analgesic Therapy
Karim S. Ladha, M.D., M.Sc.; Elisabetta Patorno, M.D., Dr.P.H.; Krista F. Huybrechts, M.S., Ph.D.; Jun Liu, M.D., M.S.; James P. Rathmell, M.D.; Brian T. Bateman, M.D., M.Sc.
Anesthesiology April 2016, Vol. 124, 837–845. https://doi.org/10.1097/ALN.0000000000001034
View Articletitled, Variations in the Use of Perioperative Multimodal Analgesic Therapy
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Does Ondansetron Modify Sympathectomy Due to Subarachnoid Anesthesia?: Meta-analysis, Meta-regression, and Trial Sequential Analysis
Abdullah S. Terkawi, M.D.; Dimitris Mavridis, Ph.D.; Pamela Flood, M.D., M.A.; Jørn Wetterslev, M.D., Ph.D.; Rayan S. Terkawi, M.D.; Aref A. Bin Abdulhak, M.D.; Megan S. Nunemaker, M.S.L.S.; Mohamed Tiouririne, M.D.
Anesthesiology April 2016, Vol. 124, 846–869. https://doi.org/10.1097/ALN.0000000000001039
View Articletitled, Does Ondansetron Modify Sympathectomy Due to Subarachnoid Anesthesia?<span class="subtitle-colon">: </span><span class="subtitle">Meta-analysis, Meta-regression, and Trial Sequential Analysis</span>
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Effect of Inhalational Anesthetics and Positive-pressure Ventilation on Ultrasound Assessment of the Great Vessels: A Prospective Study at a Children’s Hospital
Elaina E. Lin, M.D.; Aaron E. Chen, M.D.; Nova Panebianco, M.D., M.P.H.; Thomas Conlon, M.D.; Na Rae Ju, M.D.; Dustin Carlson, M.D.; Jason Kopenitz, B.S.; Akira Nishisaki, M.D., M.S.C.E.
Anesthesiology April 2016, Vol. 124, 870–877. https://doi.org/10.1097/ALN.0000000000001032
View Articletitled, Effect of Inhalational Anesthetics and Positive-pressure Ventilation on Ultrasound Assessment of the Great Vessels<span class="subtitle-colon">: </span><span class="subtitle">A Prospective Study at a Children’s Hospital</span>
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Perioperative Medicine: Basic Science

Propofol-induced Inhibition of Catecholamine Release Is Reversed by Maintaining Calcium Influx
Liping Han, M.D., M.Sc.; Stephen Fuqua, M.S.; Quanlin Li, M.D., Ph.D.; Liyu Zhu, M.D.; Xiaoyan Hao, M.D., M.Sc.; Aiping Li, M.D., M.Sc.; Sangeeta Gupta, B.S.; Ravinder Sandhu, B.S.; György Lonart, Ph.D.; Shuzo Sugita, Ph.D.
Anesthesiology April 2016, Vol. 124, 878–884. https://doi.org/10.1097/ALN.0000000000001015
View Articletitled, Propofol-induced Inhibition of Catecholamine Release Is Reversed by Maintaining Calcium Influx
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Differential Suppression of Spontaneous and Noxious-evoked Somatosensory Cortical Activity by Isoflurane in the Neonatal Rat
Pi-shan Chang, Ph.D.; Suellen M. Walker, M.B.B.S., Ph.D., F.A.N.Z.C.A.; Maria Fitzgerald, Ph.D.
Anesthesiology April 2016, Vol. 124, 885–898. https://doi.org/10.1097/ALN.0000000000001017
View Articletitled, Differential Suppression of Spontaneous and Noxious-evoked Somatosensory Cortical Activity by Isoflurane in the Neonatal Rat
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Critical Care Medicine: Clinical Science

Use of Intensive Care Services for Medicare Beneficiaries Undergoing Major Surgical Procedures
Hannah Wunsch, M.D., M.Sc.; Hayley B. Gershengorn, M.D.; Colin R. Cooke, M.D., M.Sc.; Carmen Guerra, M.P.H.; Derek C. Angus, M.D., M.P.H.; John W. Rowe, M.D.; Guohua Li, M.D., Dr.P.H.
Anesthesiology April 2016, Vol. 124, 899–907. https://doi.org/10.1097/ALN.0000000000001024
View Articletitled, Use of Intensive Care Services for Medicare Beneficiaries Undergoing Major Surgical Procedures
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Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing
Verena van der Heide, M.D.; Patrick Möhnle, M.D.; Jessica Rink, B.S.; Josef Briegel, M.D.; Simone Kreth, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 908–922. https://doi.org/10.1097/ALN.0000000000001031
View Articletitled, Down-regulation of MicroRNA-31 in CD4<sup>+</sup> T Cells Contributes to Immunosuppression in Human Sepsis by Promoting T<sub>H</sub>2 Skewing
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Critical Care Medicine: Basic Science

Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis
Simon T. Schäfer, Privatdozent Dr. med.; Lars Franken, Dr. rer. nat.; Michael Adamzik, Professor Dr. med.; Beatrix Schumak, Dr. rer. nat.; André Scherag, Professor Dr. rer. nat.; Andrea Engler, Dr. rer. nat.; Niels Schönborn; Jennifer Walden; Susanne Koch, Dr. rer. nat.; Hideo A. Baba, Professor Dr. med.; Jörg Steinmann, Privatdozent Dr. med.; Astrid M. Westendorf, Professor Dr. rer. nat.; Joachim Fandrey, Professor Dr. med.; Thomas Bieber, Professor Dr. med.; Christian Kurts, Professor Dr. med.; Stilla Frede, Privatdozent Dr. rer. nat.; Jürgen Peters, Professor Dr. med.; Andreas Limmer, Dr. rer. nat.
Anesthesiology April 2016, Vol. 124, 923–933. https://doi.org/10.1097/ALN.0000000000001008
View Articletitled, Mitochondrial DNA<span class="subtitle-colon">: </span><span class="subtitle">An Endogenous Trigger for Immune Paralysis</span>
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Pain Medicine: Basic Science

Resolvin D1 Inhibits Mechanical Hypersensitivity in Sciatica by Modulating the Expression of Nuclear Factor-κB, Phospho-extracellular Signal–regulated Kinase, and Pro- and Antiinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion
Zhi-hua Liu, M.D.; Gui-shen Miao, M.D.; Jun-nan Wang, M.D.; Cong-xian Yang, M.D.; Zhi-jian Fu, M.D., Ph.D.; Tao Sun, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 934–944. https://doi.org/10.1097/ALN.0000000000001010
View Articletitled, Resolvin D1 Inhibits Mechanical Hypersensitivity in Sciatica by Modulating the Expression of Nuclear Factor-κB, Phospho-extracellular Signal–regulated Kinase, and Pro- and Antiinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion
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Ventilation and the Response to Hypercapnia after Morphine in Opioid-naive and Opioid-tolerant Rats
Michael J. Emery, Ph.D.; Chase C. Groves, B.S.; Timothy N. Kruse, B.S.; Chen Shi, M.S.; Gregory W. Terman, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 945–957. https://doi.org/10.1097/ALN.0000000000000997
View Articletitled, Ventilation and the Response to Hypercapnia after Morphine in Opioid-naive and Opioid-tolerant Rats
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Education: Images in Anesthesiology

Ultrasonographic Images of Internal Jugular Vein Duplication
Kenji Kayashima, M.D.; Ryo Fukui, M.D.; Keiko Imai, M.D.; Koji Murashima, M.D.
Anesthesiology April 2016, Vol. 124, 958. https://doi.org/10.1097/ALN.0000000000000869
View Articletitled, Ultrasonographic Images of Internal Jugular Vein Duplication
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Bedside Ultrasound: A Tool for Assessment of IV Functionality
Adam C. Adler, M.D., M.S.; Denis H. Jablonka, M.D.
Anesthesiology April 2016, Vol. 124, 959. https://doi.org/10.1097/ALN.0000000000000884
View Articletitled, Bedside Ultrasound<span class="subtitle-colon">: </span><span class="subtitle">A Tool for Assessment of IV Functionality</span>
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Education: Clinical Concepts and Commentary

Perioperative Opioids and Public Health
Evan D. Kharasch, M.D., Ph.D.; L. Michael Brunt, M.D.
Anesthesiology April 2016, Vol. 124, 960–965. https://doi.org/10.1097/ALN.0000000000001012
View Articletitled, Perioperative Opioids and Public Health
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Education: Mind to Mind

V.I.P. Patient
Todd Lasher, M.D.
Anesthesiology April 2016, Vol. 124, 966–967. https://doi.org/10.1097/ALN.0000000000000886
View Articletitled, V.I.P. Patient
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Within a Breath
Davide Cattano, M.D., Ph.D.
Anesthesiology April 2016, Vol. 124, 968–969. https://doi.org/10.1097/ALN.0000000000000948
View Articletitled, Within a Breath
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Correspondence

Techniques to Minimize Posterior Wall Puncture during Internal Jugular Vein Cannulation
Praveen Maheshwari, M.D.; Parul Maheshwari, M.D.
Anesthesiology April 2016, Vol. 124, 970. https://doi.org/10.1097/ALN.0000000000001006
View Articletitled, Techniques to Minimize Posterior Wall Puncture during Internal Jugular Vein Cannulation
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In Reply
David B. Auyong, M.D.; Stanley C. Yuan, M.D.; Alyse N. Rymer, M.D.; Cynthia L. Green, Ph.D.; Neil A. Hanson, M.D.
Anesthesiology April 2016, Vol. 124, 970–971. https://doi.org/10.1097/ALN.0000000000001007
View Articletitled, In Reply
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One Size Does Not Fit All
Hans-Joachim Priebe, M.D.
Anesthesiology April 2016, Vol. 124, 971–974. https://doi.org/10.1097/ALN.0000000000001022
View Articletitled, One Size Does Not Fit All
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In Reply
Andreas Güldner, M.D.; Thomas Kiss, M.D.; Ary Serpa Neto, M.D., M.Sc., Ph.D.; Sabrine N. T. Hemmes, M.D.; Jaume Canet, M.D., Ph.D.; Peter M. Spieth, M.D., Ph.D.; Patricia R. M. Rocco, M.D., Ph.D.; Marcus J. Schultz, M.D., Ph.D.; Paolo Pelosi, M.D., F.E.R.S.; Marcelo Gama de Abreu, M.D., M.Sc., Ph.D., D.E.S.A.
Anesthesiology April 2016, Vol. 124, 974–975. https://doi.org/10.1097/ALN.0000000000001023
View Articletitled, In Reply
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Reviews of Educational Material

The Heart and Circulation: An Integrative Model
Anthony M. O’Leary, M.B.B.S., F.R.C.A.
Anesthesiology April 2016, Vol. 124, 976–977. https://doi.org/10.1097/ALN.0000000000000977
View Articletitled, The Heart and Circulation: An Integrative Model
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Miller’s Anesthesia, 8th Edition
Katherine T. Forkin, M.D.; Edward C. Nemergut, M.D.
Anesthesiology April 2016, Vol. 124, 977–978. https://doi.org/10.1097/ALN.0000000000001020
View Articletitled, Miller’s Anesthesia, 8th Edition
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Anesthesiology Reflections from the Wood Library-Museum

Ferdinand Hasbrouck’s Nitrous Oxide Caper—Which One?
Anesthesiology April 2016, Vol. 124, 749. https://doi.org/10.1097/01.anes.0000480997.76049.d1
View Articletitled, Ferdinand Hasbrouck’s Nitrous Oxide Caper—Which One?
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Of Blurbs and Bromides—Gelett Burgess Asks, “Are You a Bromide?”
Anesthesiology April 2016, Vol. 124, 778. https://doi.org/10.1097/01.anes.0000480998.53178.f2
View Articletitled, Of Blurbs and Bromides—Gelett Burgess Asks, “Are You a Bromide?”
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Advertising and Uncovering E. H. Neiman’s “New Anaesthetic”
Anesthesiology April 2016, Vol. 124, 884. https://doi.org/10.1097/01.anes.0000480999.60802.8c
View Articletitled, Advertising and Uncovering E. H. Neiman’s “New Anaesthetic”
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Announcements

Announcements: Announcement and Call for Abstracts
Anesthesiology April 2016, Vol. 124, 979–981. https://doi.org/10.1097/01.anes.0000481000.60802.99
View Articletitled, Announcements<span class="subtitle-colon">: </span><span class="subtitle">Announcement and Call for Abstracts</span>
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