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October 1988
Is the Metabolism of Alfentanil Subject to Debrisoquine Polymorphism? A Study Using Human Liver Microsomes
Karel L. M. Lavrijsen, Ph.D.;
Karel L. M. Lavrijsen, Ph.D.
*Group Leader, Department of Drug Metabolism and Pharmacokinetics.
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Jos M. G. Van Houdt, Grad. Chem.;
Jos M. G. Van Houdt, Grad. Chem.
†Staff Member, Department of Drug Metabolism and Pharmacokinetics.
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Dirk M. J. Van Dyck, Grad. Chem.;
Dirk M. J. Van Dyck, Grad. Chem.
†Staff Member, Department of Drug Metabolism and Pharmacokinetics.
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Jan J. J. M. Hendrickx, Grad. Chem.;
Jan J. J. M. Hendrickx, Grad. Chem.
†Staff Member, Department of Drug Metabolism and Pharmacokinetics.
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Robert J. H. Woestenborghs, Chem. Eng.;
Robert J. H. Woestenborghs, Chem. Eng.
*Group Leader, Department of Drug Metabolism and Pharmacokinetics.
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William Lauwers, Ph.D.;
William Lauwers, Ph.D.
‡Group Leader, Department of Analytical Research.
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Willem E. G. Meuldermans, Ph.D.;
Willem E. G. Meuldermans, Ph.D.
*Group Leader, Department of Drug Metabolism and Pharmacokinetics.
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Joseph J. P. Heykants, Ph.D.
Joseph J. P. Heykants, Ph.D.
§Director, Department of Drug Metabolism and Pharmacokinetics.
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¶ McDonnell TE, Bartkowski RR, Kahn C: Evidence for polymorphic oxidation of alfentanil in man (abstract). ANESTHESIOLOGY 61:A284, 1984.
** Kahn C, Rubenfield H, Bartkowski R, McDonnell TE: Competitive inhibition of debrisoquine and phenacetin oxidation by alfentanil in human liver (abstract). North American Symposium on Risk Assessment and the Biological Fate of Xenobiotics, Florida, International Society for the Study of Xenobiotics, 1985, p 31.
Anesthesiology October 1988, Vol. 69, 535–540.
Citation
Karel L. M. Lavrijsen, Jos M. G. Van Houdt, Dirk M. J. Van Dyck, Jan J. J. M. Hendrickx, Robert J. H. Woestenborghs, William Lauwers, Willem E. G. Meuldermans, Joseph J. P. Heykants; Is the Metabolism of Alfentanil Subject to Debrisoquine Polymorphism? A Study Using Human Liver Microsomes. Anesthesiology 1988; 69:535–540 doi: https://doi.org/10.1097/00000542-198810000-00013
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