Skip Nav Destination
Article navigation
Education|
July 1981
Toxicity of Lidocaine in Adult, Newborn, and Fetal Sheep
H. O. Morishima, M.D., Ph.D.;
H. O. Morishima, M.D., Ph.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
H. Pedersen, M.D.;
H. Pedersen, M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
M. Finster, M.D.;
M. Finster, M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
K. Sakuma, M.D.;
K. Sakuma, M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
S. L. Bruce, M.D.;
S. L. Bruce, M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
B. B. Gutsche, M.D.;
B. B. Gutsche, M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
R. I. Stark, M.D.;
R. I. Stark, M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
B. G. Covino, Ph.D., M.D.
B. G. Covino, Ph.D., M.D.
* Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
† Assistant Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
† Professor of Anesthesiology, Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
§ Visiting Fellow in Pediatrics, College of Physicians and Surgeons of Columbia University.
∂ Fellow in Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University.
** Visiting Associate Professor of Anesthesiology, College of Physicians and Surgeons of Columbia University.
†† Assistant Professor of Pediatrics, College of Physicians and Surgeons of Columbia University.
‡‡ Professor of Anesthesia, Harvard Medical School, and Anesthesiologist-in-Chief, Brigham and Women's Hospital.
Search for other works by this author on:
Anesthesiology July 1981, Vol. 55, 57–61.
Citation
H. O. Morishima, H. Pedersen, M. Finster, K. Sakuma, S. L. Bruce, B. B. Gutsche, R. I. Stark, B. G. Covino; Toxicity of Lidocaine in Adult, Newborn, and Fetal Sheep. Anesthesiology 1981; 55:57–61 doi: https://doi.org/10.1097/00000542-198107000-00012
Download citation file:
Citing articles via
Most Viewed
Related Articles
Disposition of Bupivacaine and Its Metabolites in the Maternal, Placental, and Fetal Compartments in Rats
Anesthesiology (October 2000)
Anesthetic Techniques for Fetal Surgery: Effects of Maternal Anesthesia on Intraoperative Fetal Outcomes in a Sheep Model
Anesthesiology (April 2013)
Fetal Plasma Concentrations after Intraamniotic Sufentanil in Chronically Instrumented Pregnant Sheep
Anesthesiology (June 2003)
Comparative Systemic Toxicity of Ropivacaine and Bupivacaine in Nonpregnant and Pregnant Ewes
Anesthesiology (March 1995)