There is insufficient prospective evidence regarding the relationship between surgical experience and prolonged opioid use and pain. In this issue of Anesthesiology, Kuck et al. investigated the association of patient characteristics, surgical procedure, and perioperative anesthetic course with postoperative opioid consumption and pain 3 months postsurgery. In an accompanying editorial, Ladha and Schreiber examine the relationship between postoperative pain and opioid use in the wake of the opioid crisis. Cover illustration: A. Johnson, Vivo Visuals Studio.

  • Kuck et al.: Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study, p. 462

  • Ladha and Schreiber: Uncoupling Pain and Opioid Use after Surgery, p. 457