Ketamine is often used for the management of refractory chronic pain, yet there are few trials exploring its analgesic after intravenous administration or in association with magnesium. In this issue of Anesthesiology, Pickering et al. report negligible effect of ketamine with or without magnesium 5 weeks after intravenous infusion. In an accompanying Editorial, Clark calls for de-emphasizing use of infused ketamine until and unless we can determine how to use the drug to benefit patients. Cover Illustration: S. M. Jarret, M.F.A., C.M.I. Photo: J. P. Rathmell.

  • Pickering et al.: Ketamine and Magnesium for Refractory Neuropathic Pain: A Randomized, Double–blind, Crossover Trial, p. 154

  • Clark: Ketamine for Chronic Pain: Old Drug New Trick? p. 13