We thank Dr. Riopelle for his question. In the article,1 table 2 contains the results of unadjusted comparisons across study arms for all pain endpoints. In addition to these unadjusted comparisons, for the study’s primary endpoint an analysis was performed to assess differences across study arms after adjusting for sex, American Society of Anesthesiologists status, and type of anesthesia. In all cases, the results of the unadjusted and adjusted comparisons across treatment groups were consistent.
Regarding Dr. Riopelle’s request for clarification of postoperative pain score data by anesthesia type, table 1 summarizes postoperative pain scores in each treatment arm for patients who received general versus spinal anesthesia.
Internal funding was received from the Department of Anesthesiology and the Department of Orthopedics, Mayo Clinic, Rochester, Minnesota.
The authors declare no competing interests.