Ketamine, used for more than 60 yr as a sedative, analgesic, and anesthetic, is now being explored as a rapidly acting antidepressant. An article in this month’s issue highlights the metabolites which may be responsible for this rapid antidepressant effect. (Illustration by A. Johnson, Vivo Visuals.)

  • van Velzen and Dahan: Ketamine Metabolomics in the Treatment of Major Depression, p. 4

  • Paul et al.: (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function, p. 149