We thank the authors for their thoughtful letter and informative review regarding the effects of anesthesia on the cardiovascular system. This previous work using animal models has been foundational in framing our understanding of arterial physiology and the effects of anesthetic agents. Our omission of these previous works in our recently published review on aortic biomechanics was not meant to diminish their importance. Rather, the purpose of our review was to focus on concepts related to the material properties of the aorta itself in health, disease, surgery, and anesthesia, and to propose that local aortic changes may have both physiologic and clinical ramifications through the aorta’s relationship with the heart and distal arteries.

Certainly, the previous studies highlighted by Dr. Pagel et al., using a three-element Windkessel model in animals, have provided important details on the effects of anesthesia on aortic biomechanics. But we respectfully submit that...

You do not currently have access to this content.